An interventional study of DHA-NAT and Placebo in Hypertriglyceridemia, sponsored by University Hospital, Gentofte, Copenhagen. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by University Hospital, Gentofte, Copenhagen · Not applicable, Interventional, and Prevention
This study is an investigator-initiated, randomised, double-blind, placebo-controlled, cross-over human trial investigating the effect of DHA-NAT (C22:6 N-acyl taurine, an endogenous metabolite derived from the omega-3 fatty acid, docosahexaenoic acid) on postprandial plasma triglyceride levels following a high-fat meal.
324 studies on the registry are indexed under Hypertriglyceridemia; 38 are open to participants now.
This study's enrollment of 20 is below the median of 66 across 288 interventional studies indexed under Hypertriglyceridemia.
Browse Hypertriglyceridemia studies →University Hospital, Gentofte, Copenhagen is the lead sponsor of 162 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Two enzymes measured in a routine blood test of the liver. Higher levels can mean the liver is under strain or damaged. SGPT and SGOT are older names for ALT and AST.
Criteria usually give a limit as a multiple of the upper limit of normal (ULN), often higher when cancer has spread to the liver.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hemoglobin (Hb)
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ALT and AST (liver enzymes)
Two enzymes measured in a routine blood test of the liver. Higher levels can mean the liver is under strain or damaged. SGPT and SGOT are older names for ALT and AST.
Criteria usually give a limit as a multiple of the upper limit of normal (ULN), often higher when cancer has spread to the liver.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Oral administration with a test meal of 55 kJ/kg bodyweight, with 60% of calories from fat.
Other: DHA-NAT
Oral administration with a test meal of 55 kJ/kg bodyweight, with 60% of calories from fat.
Other: Placebo
Endogenous metabolite of omega-3 fatty acid docosahexaenoic acid
Also known as: C22:6 N-acyl taurine
Vehicle control (H2O) for the intervention used in the experimental arm (DHA-NAT).
Plasma triglyceride
Change in incremental area-under-curve plasma triglyceride
Time frame: 0-240 minutes
Plasma GLP-1
Plasma GLP-1 profile
Time frame: 0-240 minutes
Plasma N-acyl taurine species
Profile of plasma n-acyl taurine species
Time frame: 0-240 minutes
Plasma ApoB48
Plasma ApoB48 profile
Time frame: 0-240 minutes
Satiety, hunger and appetite
Development during study day recorded by visual analogue scale (VAS), 0-10 cm where 0 = not in agreement with statement and 10 = in agreement with statement.
Time frame: 0-240 minutes
Food intake (g)
Grams consumed of a standard ad libitum meal
Time frame: t=240 minutes
Food intake (kcal)
kcal consumed of a standard ad libitum meal
Time frame: t=240 minutes
Plasma triglyceride (TG) distribution
total TG, and TG in HDL, LDL and VLDL cholesterol, remnant TG
Time frame: 0-240 minutes
Plasma free fatty acid species
Total fatty acids profile
Time frame: 0-240 minutes
Plasma cholesterol
Total cholesterol, HDL, LDL, VLDL, remnant cholesterol
Time frame: 0-240 minutes
Plasma level of glucose regulating hormones
Insulin, glucagon and gastric inhibitory polypeptide
Time frame: 0-240 minutes
Plasma amino acids
Total amino acids profile
Time frame: 0-240 minutes
Plasma glucose
Plasma glucose profile
Time frame: 0-240 minutes
Plasma bile acid species
Plasma bile acid profile
Time frame: 0-240 minutes
Gall bladder emptying: Cholecystokinin
Cholecystokinin profile
Time frame: 0-240 minutes
Gall bladder emptying: Ultrasonography
Difference in volume from most to least full
Time frame: 0-240 minutes
Gastric emptying: Paracetamol
Plasma acetaminphen profile
Time frame: 0-240 minutes
Stool quality
Self-assessment of stool quality by the Bristol Stool Scale (1-7, where 1 = most solid and 7 = least solid)
Time frame: Up to 24 hours from ingestion of test meal or until first bowel movement if later than 24 hours.
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2023 to primary completion in Oct 2023, 9 months.
Of 42 non-industry interventional studies with no phase under Hypertriglyceridemia, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 39. This study's 9 months is below that.
Counting every sponsor, half of 45 studies reached it within 23 months; a quarter within 7 and three quarters within 33.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Hospital, Gentofte, Copenhagen →