An interventional study of Gingival depigmentation using blue laser in non-contact mode and Gingival depigmentation using blue laser in contact mode in Physiological Gingival Hyperpigmentation, sponsored by Beirut Arab University. Completed at 1 site in Lebanon. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Beirut Arab University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to compare clinical and digital color parameter results of gingival depigmentation using blue laser in both contact and non- contact modes in patients with physiological gingival hyperpigmentation. The main questions it aims to answer are:
Participants will undergo:
127 studies on the registry are indexed under Hyperpigmentation; 28 are open to participants now.
This study's enrollment of 20 is below the median of 32 across 113 interventional studies indexed under Hyperpigmentation.
Browse Hyperpigmentation studies →Beirut Arab University is the lead sponsor of 16 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
This group underwent gingival depigmentation using blue laser in non-contact mode.
Procedure: Gingival depigmentation using blue laser in non-contact mode
This group underwent gingival depigmentation using blue laser in contact mode.
Procedure: Gingival depigmentation using blue laser in contact mode
Infiltration anesthesia using 4% Articaine was given. Blue light laser (445 nm, 1.5 W) was applied to patients with physiologic hyperpigmentation using 300 µm fiber-optic tip at a distance of 2mm from the target area in constant movement until gingival blanching was observed.
Infiltration anesthesia using 4% Articaine was given. Blue light laser (445 nm, 1 W) was applied to patients with physiologic hyperpigmentation using 300 µm fiber-optic tip directly touching the target area until ablation was observed.
Postoperative pain
Postoperative pain will be assessed using a 10-cm Visual Analog Scale (VAS), with 0 representing no pain and 10 representing the worst pain imaginable. Participants will record their perceived pain following the laser depigmentation procedure. Unit of measure: Score
Time frame: immediately after the procedure, 24 hours post operatively, and 7 days post operatively.
Degree of gingival pigmentation
Degree of gingival pigmentation was assessed using the Dummett Oral Pigmentation Index (DOPI).
Time frame: 1 and 3 months after completion of the procedure.
Extent and distribution of gingival pigmentation
Extent and distribution of gingival pigmentation were measured using Hedin Melanin Index (HMI)
Time frame: 1 and 3 months after completion of the procedure.
Changes in gingival color
Changes in gingival color will be assessed by calculating ΔE from standardized digital photographs using CIELAB L\*, a\*, and b\* color coordinates. ΔE represents the overall color difference between baseline and postoperative measurements. Unit of measure: None/ dimensionless
Time frame: 1 and 3 months after completion of the procedure
Plan to share: Undecided
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Beirut Arab University