Hyperoxia clinical trials
The registry lists 115 studies for Hyperoxia across more than 10 countries. 13 are recruiting or about to start. 55 of them are mainly about Hyperoxia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University of Edinburgh (4) · University of Colorado, Denver (4) · Amsterdam UMC, location VUmc (3) · Laval University (3) · Tepecik Training and Research Hospital (3) · Insel Gruppe AG, University Hospital Bern (3) · Zonguldak Bulent Ecevit University (3) · University of Modena and Reggio Emilia (2)
What is being tested here
Drugs under test in Hyperoxia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Oxygen | 1 | 2 | 18 |
| Acetazolamide | 1 | 0 | 1 |
| Finasteride | 1 | 0 | 1 |
| Ascorbic Acid | 0 | 0 | 1 |
| Lipopolysaccharides | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Perioperative UtiLisation of SupplEmental Oxygen · University Hospital Southampton NHS Foundation Trust
- Dec 2026Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury? · University of Alberta
- Dec 2026HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics · Erasme University Hospital
- Apr 2027Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia · Fatih Sultan Mehmet Training and Research Hospital
- Apr 2027Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter? · Eastern Switzerland University of Applied Sciences
- Jul 2027Sleep Apnea in Elderly · VA Office of Research and Development
Who these studies take
Of the 7 Hyperoxia studies recruiting now, 3 (43%) set no upper age limit and 1 (14%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (43%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 6 (86%) | 6 (86%) |
| 30 | 6 (86%) | 6 (86%) |
| 40 | 6 (86%) | 6 (86%) |
| 50 | 6 (86%) | 6 (86%) |
| 65 | 7 (100%) | 7 (100%) |
| 75 | 6 (86%) | 6 (86%) |
| 85 | 6 (86%) | 6 (86%) |
Across all 115 studies, recruiting or not: 35% stop at 75 or younger and 28% at 65; 17% take children; 1% are for women only and 3% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperoxia studies take
Of 39 interventional studies with no phase under Hyperoxia, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 12 mo5–33 · 39 studies | — | 16 mo5–33 · 37 studies |
| Observational | 20 mo12–25 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Results posted2
- Delayed Cord Clamping With Oxygen In Extremely Low Gestation InfantsOct 15, 2026NCT04413097
- Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration InterventionOct 14, 2026NCT06374225
Studies
Recruiting first, then most recently updated. Showing 50 of 115. Browse all 115 → or search them.
- Treating Spinal Cord Injury With Early Normobaric HyperoxiaRecruitingNCT07465302Phase 21 country
- Hyperoxemia and Oxygen Reserve Index During Neurointerventional AnesthesiaNot yet recruitingNCT078599821 country
- Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?RecruitingNCT05467215Early Phase 11 country
- Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?RecruitingNCT06776731Not applicable1 country
- Sleep Apnea in ElderlyRecruitingNCT02703220Phase 41 country
- ORI-Guided Oxygen Therapy During One-Lung VentilationNot yet recruitingNCT07720778Not applicable1 country
- Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair PositionNot yet recruitingNCT07404267Not applicable1 country
- HYPER MIND - Hyperoxia Effects on Cerebral HemodynamicsRecruitingNCT07377162Not applicable1 country
- The Effect of Respiratory Challenge on the BOLD SignalEnrolling by invitationNCT04258774Not applicable1 country
- Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU PatientsNot yet recruitingNCT07332637
- Effect of Hydrogen Gas on Hyperbaric Oxygen ToxicityNot yet recruitingNCT07263399Not applicable1 country
- Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac SurgeryRecruitingNCT04808401Not applicable1 country
- Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).RecruitingNCT054128101 country
- Delayed Cord Clamping With Oxygen In Extremely Low Gestation InfantsActive, not recruitingNCT04413097Not applicable1 country
- Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration InterventionCompletedNCT06374225Not applicable1 country
- Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPDCompletedNCT03464695Not applicable1 country
- Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical PatientsCompletedNCT05354648Not applicable
- Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT)CompletedNCT07369232Not applicable1 country
- Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.CompletedNCT07551869Not applicable1 country
- Effect of Hyperoxia or Hypoxemia on the Incidence of Delirium in Patients After Cardiac SurgeryCompletedNCT075489051 country
- ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea TestCompletedNCT069839901 country
- Perioperative Hyperoxia vs Normoxia Biomarker TrialCompletedNCT07525661Not applicable1 country
- Hyperoxia vs Normoxia During Cardiopulmonary BypassCompletedNCT07510672Not applicable1 country
- Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care UnitCompletedNCT04879290Not applicable1 country
- The Association Between Sensory Block Level, Oxygen Therapy, and ORi in Varicose Vein Patients Undergoing Spinal Anesthesia (ORi: Oxygen Reserve Index)CompletedNCT065666901 country
- Oxygen Reserve Index Guided FiO₂ Titration in One-Lung VentilationCompletedNCT07359833Not applicable1 country
- Effect of Hyperbaric Oxygen Therapy on MicrocirculationCompletedNCT03980210Not applicable1 country
- Can Atelectasis Be Prevented With Oxygen Reserve Index (ORI) Monitoring?CompletedNCT07050719Not applicable1 country
- Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory SupportCompletedNCT06622161Not applicable1 country
- Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty SurgeryCompletedNCT07158073Not applicable1 country
- Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHopTerminatedNCT03835741Not applicable1 country
- NICU Oxygen Control StudyCompletedNCT04269161Not applicable1 country
- Oximeters and Skin Pigment: Impact of Skin Pigmentation on Accuracy of Pulse OximetryCompletedNCT056902691 country
- Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer SurgeryCompletedNCT069893461 country
- Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)SuspendedNCT05923853Not applicable1 country
- Strategy to Avoid Excessive Oxygen for Critically Ill Trauma PatientsActive, not recruitingNCT04534959Phase 31 country
- Strategy to Avoid Excessive Oxygen in Major Burn PatientsActive, not recruitingNCT04534972Phase 31 country
- Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult VolunteersCompletedNCT06555484Not applicable1 country
- Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic ShockCompletedNCT04990349Phase 31 country
- Oxygen Reserve Index in Different Fresh Gas FlowCompletedNCT066492791 country
- Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. NellcorCompletedNCT04866342Not applicable1 country
- Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry TrialCompletedNCT03841084Phase 21 country
- The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric PatientsCompletedNCT063263721 country
- Pulmonary Function After Hyperbaric Oxygen TherapyCompletedNCT050887721 country
- Pilot Study of Targeted Normoxia in Critically Ill Trauma PatientsCompletedNCT037893961 country
- Risk of Oxygen During Cardiac Surgery TrialCompletedNCT02361944Phase 2/31 country
- Perioperative UtiLisation of SupplEmental OxygenActive, not recruitingNCT03552627Phase 41 country
- Intelligent Oxygen Therapy During Activities of Daily LivingCompletedNCT02683486Not applicable1 country
- Blender Biomarkers: A BLENDER Sub-study to Evaluate the Effect of Oxygen Dose on Oxidative Stress and Organ InjuryActive, not recruitingNCT055429661 country
- SCO2T (Servo vs. Servo)TerminatedNCT04546568Not applicable1 country