An interventional study of Cross Over Assignment Supplemental Oxygen and Supplemental Air in Cognition, sponsored by Inogen Inc.. Completed at 1 site in United States. Open to participants aged 22 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-31.
Sponsored by Inogen Inc. · Not applicable, Interventional, and Basic science
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.
Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).
115 studies on the registry are indexed under Hyperoxia; 13 are open to participants now.
This study's enrollment of 40 is below the median of 48 across 82 interventional studies indexed under Hyperoxia.
Browse Hyperoxia studies →Inogen Inc. is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
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Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.
Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air
All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.
Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air
Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).
2 back Memory test performance
# correct on 2-back test
Time frame: At baseline and 5 mins post-intervention exposure
Memory test performance
New Medical Icons Spatial Test
Time frame: At baseline and 5 mins post-intervention exposure
Plan to share: No
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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Inogen Inc.