An interventional study of FIO2 modulation during HIIT protocol on assault bike in Hyperoxia / High FiO₂ Exposure, Interval Training and HIIT, sponsored by Haute Ecole Bruxelles-Brabant. Completed at 1 site in Belgium. Open to male participants aged 19 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-30.
Sponsored by Haute Ecole Bruxelles-Brabant · Not applicable, Interventional, and Basic science
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects:
If you agree to participate, you will undergo the following:
Baseline testing:
Training intervention (3 weeks):
During training, you will breathe either:
Post-intervention testing:
The risks associated with this study are similar to those encountered during high-intensity exercise:
Breathing altered oxygen concentrations (hypoxia or hyperoxia) may induce:
You may benefit from:
All collected data will be:
You have the right to:
115 studies on the registry are indexed under Hyperoxia; 13 are open to participants now.
This study's enrollment of 23 is below the median of 48 across 82 interventional studies indexed under Hyperoxia.
Browse Hyperoxia studies →Haute Ecole Bruxelles-Brabant is the lead sponsor of 4 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
inspired oxygen fraction (FiO₂) = 0.60 during Tabatha protocol
Other: FIO2 modulation during HIIT protocol on assault bike
inspired oxygen fraction (FiO₂) = 0.16 during Tabatha protocol
Other: FIO2 modulation during HIIT protocol on assault bike
Normobaric hyperoxic breathing during high-intensity interval training (FiO2 0.60) and hypoxic (FiO2 0.16)
maximal oxygen uptake (VO₂max)
VO2max represents the maximal rate at which an individual can consume oxygen during incremental exercise. It is measured during a graded exercise test (e.g., treadmill or cycle ergometer) using indirect calorimetry. It reflects aerobic capacity and cardiovascular fitness. Higher values indicate better aerobic performance and endurance capacity.
Time frame: From enrollment to the end of protocol at 3 weeks
the first and second ventilatory thresholds (VT1, VT2)
VT1 (first ventilatory threshold) corresponds to the exercise intensity at which ventilation begins to increase disproportionately relative to oxygen uptake, indicating the onset of lactate accumulation. VT2 (second ventilatory threshold) marks a further disproportionate increase in ventilation due to metabolic acidosis. These thresholds are determined from gas exchange analysis during exercise testing and reflect submaximal aerobic and anaerobic transition points.
Time frame: from enrollment to the end of the protocol at 3 weeks
peak blood lactate
Peak blood lactate is the highest concentration of lactate measured in the blood during or immediately after maximal exercise. It is assessed via capillary or venous blood sampling. This measure reflects the degree of anaerobic metabolism and glycolytic contribution during high-intensity effort.
Time frame: from enrollment to the end of protocol at 3 weeks
session rating of perceived exertion (RPE).
RPE is a subjective measure of exercise intensity based on an individual's perception of effort, typically assessed using standardized scales such as the Borg scale (6-20 or 0-10). It integrates physiological and psychological responses to exercise and is useful for monitoring training load and tolerance.
Time frame: from enrollment to the end of the protocol at 3 weeks
Plan to share: No — Data are collected for this study only. The experiments opens new questions and so new data collection
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Haute Ecole Bruxelles-Brabant