Hyperkalemia clinical trials
The registry lists 122 studies for Hyperkalemia across more than 10 countries. 24 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-21.
Status
- Completed
- 73
- Recruiting
- 14
- Terminated
- 12
- Not yet recruiting
- 8
- Status unknown
- 7
- Active, not recruiting
- 5
Phase
- Phase 4
- 24
- Phase 3
- 23
- Phase 2
- 17
- Phase 1
- 5
Where
- United States
- 47
- China
- 18
- United Kingdom
- 14
- Italy
- 12
- Canada
- 12
- Japan
- 11
Who runs them
AstraZeneca (29) · ZS Pharma, Inc. (8) · Relypsa, Inc. (6) · Waterstone Pharmaceutical (Wuhan) Co., LTD. (3) · Vifor Pharma, Inc. (3) · Qianfoshan Hospital (2) · Portsmouth Hospitals NHS Trust (2) · Zeria Pharmaceutical (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 122 — search for more.
- Effect of Patiromer in Children Under 12 Years of Age With High Blood Potassium LevelsRecruitingNCT05766839Phase 215 countries
- Observational Study on the Prevalence and Risk Factors of Patients With Hyperkalaemia in BrazilRecruitingNCT073701941 country
- Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot TrialNot yet recruitingNCT07775482Not applicable1 country
- Liberalizing Potassium Restrictions in Patients Receiving HemodialysisNot yet recruitingNCT07772856Not applicable1 country
- An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With HyperkalaemiaRecruitingNCT03813407Phase 313 countries
- Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot StudyNot yet recruitingNCT07494266Not applicable1 country
- Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety StudyNot yet recruitingNCT07523867Phase 4
- Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)Not yet recruitingNCT07547878Phase 41 country
- Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency DepartmentEnrolling by invitationNCT06724991Not applicable1 country
- Adding Urea to the Final Dialysis FluidRecruitingNCT06366230Phase 1/21 country
- Effects of Minimally vs. Ultra-Processed Diets on Potassium (K) Handling in CKDNot yet recruitingNCT06920914Not applicable
- AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emulation StudyNot yet recruitingNCT07307729Not applicable
- Potassium Correction for RAAS Optimization in Chronic Kidney DiseaseRecruitingNCT06256991Phase 41 country
- A Two-Part, Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of HyperkalemiaRecruitingNCT07251309Phase 31 country
- AK+ Guard™ Pilot Study in Chronic Kidney Disease: Outpatient Diagnostic Accuracy and Remote MonitoringRecruitingNCT072100211 country
- Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5RecruitingNCT06901960Not applicable1 country
- Patiromer and Diet/hrQoL in Chronic DialysisRecruitingNCT06858280Phase 31 country
- Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in CommunityRecruitingNCT069404141 country
- Sodium Zirconium Cyclosilicate to Allow Liberal Fruit and Vegetable Intake for Patients With CKD Stage 3b and 4RecruitingNCT06365684Phase 41 country
- COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG WearableEnrolling by invitationNCT067635491 country
- The Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis PatientsNot yet recruitingNCT06736184Phase 4
- Chronic Kidney Disease, Hyperkalemia and Echocardiographic ChangesRecruitingNCT066355901 country
- Low-potassium Content Vegetables in Chronic Kidney DiseaseRecruitingNCT06428942Not applicable1 country
- A Study to Evaluate the Safety and Efficacy of WS016 in Patients With Hyperkalemia.RecruitingNCT06277128Phase 21 country
- Dietary Potassium Liberalization in Pre-Dialysis PatientsCompletedNCT05090865Not applicable1 country
- Hyperkalemia Quality Improvement Program (HK-QIP) StudyActive, not recruitingNCT06884267Not applicable1 country
- Potassium Supplementation in CKDActive, not recruitingNCT03253172Not applicable1 country
- VITALIZE.Use and Effectiveness of Sodium Zirconium Cyclosilicate (LokelmaTM) in the Real-world Setting in SpainCompletedNCT066354991 country
- Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute HyperkalemiaCompletedNCT04012138Phase 41 country
- Lokelma for RAAS Maximisation in CKD & Heart Failure.CompletedNCT05004363Phase 31 country
- Trial Evaluating the Efficacy and Safety of Patiromer in Chinese SubjectsCompletedNCT05136664Phase 31 country
- Prediction of Hyperkalemia in Dialysis Patients Through Waveform Analysis Using Wearable ECGCompletedNCT070549051 country
- A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of HyperkalaemiaTerminatedNCT05056727Phase 321 countries
- A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in GreeceCompletedNCT061856601 country
- IMpact of hyPeRkalaemia on thErapy With Renin angiotenSin aldoSterone System InhibitorsWithdrawnNCT045107921 country
- 5 Versus 10 Units of Insulin in Hyperkalemia ManagementCompletedNCT06036823Phase 41 country
- Evidence for Potassium Restriction in HemodialysisActive, not recruitingNCT06120608Not applicable1 country
- Nurse-Led Nutritional Education for Moroccan Dialysis PatientsCompletedNCT07277530Not applicable1 country
- Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge StudyCompletedNCT05347693Phase 46 countries
- An Observational Prospective Cohort Study for Long-term Management of Hyperkalemia in Patients With Chronic Kidney Disease or Heart FailureCompletedNCT052974091 country
- Tracking Treatment Pathways in Adult Patients With Hyperkalemia.CompletedNCT054080395 countries
- Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving SpironolactoneCompletedNCT04676646Phase 48 countries
- OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart FailureActive, not recruitingNCT04789239Phase 21 country
- Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)TerminatedNCT04847232Phase 326 countries
- The ORTIZ Study: Optimising RASi Therapy With SZCTerminatedNCT04983979Phase 21 country
- Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease PatientsCompletedNCT03781089Phase 41 country
- A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia.CompletedNCT03528681Phase 32 countries
- Targeted Potassium Levels for Prevention of ICD TherapyActive, not recruitingNCT03833089Phase 41 country
- Effect of Viscous Fiber on Postprandial Kalemic Response in Hemodialysis PatientsCompletedNCT050861851 country
- SZC Versus SPS for Treatment of Hyperkalemia in Hemodialysis PatientsCompletedNCT06029179Not applicable1 country