Hyperkalemia clinical trials
The registry lists 133 studies for Hyperkalemia across more than 10 countries. 25 are recruiting or about to start. 89 of them are mainly about Hyperkalemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
AstraZeneca (30) · ZS Pharma, Inc. (8) · Relypsa, Inc. (7) · Waterstone Pharmaceutical (Wuhan) Co., LTD. (4) · Vifor Pharma, Inc. (3) · US Department of Veterans Affairs (2) · National Defense Medical Center, Taiwan (2) · Peking University First Hospital (2)
What is being tested here
Drugs under test in Hyperkalemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Patiromer | 3 | 5 | 21 |
| WS016 | 3 | 2 | 4 |
| Finerenone | 3 | 0 | 3 |
| Sodium zirconium cyclosilicate | 2 | 13 | 26 |
| Lisinopril | 1 | 1 | 2 |
| Semaglutide | 1 | 0 | 1 |
| Benazepril | 1 | 0 | 1 |
| Captopril | 1 | 0 | 1 |
| Enalapril | 1 | 0 | 1 |
| Fosinopril | 1 | 0 | 1 |
Drug classes tested here Mineralocorticoid receptor antagonists (MRAs) 3 open · Diuretics 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Nov 2026A Two-Part, Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of Hyperkalemia · Phase 3 · Waterstone Pharmaceutical (Wuhan) Co., LTD.
- Dec 2026Potassium Correction for RAAS Optimization in Chronic Kidney Disease · University Medical Center Groningen
- Dec 2026The Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis Patients · Qianfoshan Hospital
- Dec 2026Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5 · Peking University First Hospital
- Mar 2027AK+ Guard™ Pilot Study in Chronic Kidney Disease: Outpatient Diagnostic Accuracy and Remote Monitoring · AccurKardia, Inc.
- Jun 2027Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency Department · University of Malaya
Who these studies take
Of the 15 Hyperkalemia studies recruiting now, 10 (67%) set no upper age limit and 2 (13%) stop at 75 or younger. 2 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (13%) | 2 (13%) |
| 18 | 12 (80%) | 12 (80%) |
| 30 | 13 (87%) | 13 (87%) |
| 40 | 13 (87%) | 13 (87%) |
| 50 | 13 (87%) | 13 (87%) |
| 65 | 13 (87%) | 13 (87%) |
| 75 | 13 (87%) | 13 (87%) |
| 85 | 13 (87%) | 13 (87%) |
Across all 133 studies, recruiting or not: 12% stop at 75 or younger and 8% at 65; 10% take children; 0% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperkalemia studies take
Of 18 phase 3 interventional studies under Hyperkalemia, half reached primary completion within 16 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 16 mo11–29 · 18 studies | — | — |
| Phase 4 | 24 mo23–44 · 16 studies | — | — |
| Interventional, no phase | 25 mo8–28 · 16 studies | — | — |
| Observational | 16 mo8–27 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 133. Browse all 133 → or search them.
- AK+ Guard™ Pilot Study in Chronic Kidney Disease: Outpatient Diagnostic Accuracy and Remote MonitoringEnrolling by invitationNCT072100211 country
- A Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of HyperkalemiaRecruitingNCT07881965Phase 31 country
- Effects of Minimally vs. Ultra-Processed Diets on Potassium (K) Handling in CKDNot yet recruitingNCT06920914Not applicable
- Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)Enrolling by invitationNCT07547878Phase 41 country
- Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot StudyRecruitingNCT07494266Not applicable1 country
- Effect of Patiromer in Children Under 12 Years of Age With High Blood Potassium LevelsRecruitingNCT05766839Phase 215 countries
- Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot TrialNot yet recruitingNCT07775482Not applicable1 country
- Liberalizing Potassium Restrictions in Patients Receiving HemodialysisNot yet recruitingNCT07772856Not applicable1 country
- An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With HyperkalaemiaRecruitingNCT03813407Phase 313 countries
- Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety StudyNot yet recruitingNCT07523867Phase 4
- Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency DepartmentEnrolling by invitationNCT06724991Not applicable1 country
- Adding Urea to the Final Dialysis FluidRecruitingNCT06366230Phase 1/21 country
- AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emulation StudyNot yet recruitingNCT07307729Not applicable
- Potassium Correction for RAAS Optimization in Chronic Kidney DiseaseRecruitingNCT06256991Phase 41 country
- A Two-Part, Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of HyperkalemiaRecruitingNCT07251309Phase 31 country
- Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5RecruitingNCT06901960Not applicable1 country
- Patiromer and Diet/hrQoL in Chronic DialysisRecruitingNCT06858280Phase 31 country
- Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in CommunityRecruitingNCT069404141 country
- Sodium Zirconium Cyclosilicate to Allow Liberal Fruit and Vegetable Intake for Patients With CKD Stage 3b and 4RecruitingNCT06365684Phase 41 country
- COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG WearableEnrolling by invitationNCT067635491 country
- The Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis PatientsNot yet recruitingNCT06736184Phase 4
- Chronic Kidney Disease, Hyperkalemia and Echocardiographic ChangesRecruitingNCT066355901 country
- Low-potassium Content Vegetables in Chronic Kidney DiseaseRecruitingNCT06428942Not applicable1 country
- A Study to Evaluate the Safety and Efficacy of WS016 in Patients With Hyperkalemia.RecruitingNCT06277128Phase 21 country
- The Effect of Potassium Lowering Drugs on Cardiac Electrical Stability in Hemodialysis Patients (ART Study)RecruitingNCT06242041Phase 41 country
- Evidence for Potassium Restriction in HemodialysisCompletedNCT06120608Not applicable1 country
- Observational Study on the Prevalence and Risk Factors of Patients With Hyperkalaemia in BrazilCompletedNCT073701941 country
- Dietary Potassium Liberalization in Pre-Dialysis PatientsCompletedNCT05090865Not applicable1 country
- Hyperkalemia Quality Improvement Program (HK-QIP) StudyActive, not recruitingNCT06884267Not applicable1 country
- Potassium Supplementation in CKDActive, not recruitingNCT03253172Not applicable1 country
- VITALIZE.Use and Effectiveness of Sodium Zirconium Cyclosilicate (LokelmaTM) in the Real-world Setting in SpainCompletedNCT066354991 country
- Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute HyperkalemiaCompletedNCT04012138Phase 41 country
- Lokelma for RAAS Maximisation in CKD & Heart Failure.CompletedNCT05004363Phase 31 country
- Trial Evaluating the Efficacy and Safety of Patiromer in Chinese SubjectsCompletedNCT05136664Phase 31 country
- Prediction of Hyperkalemia in Dialysis Patients Through Waveform Analysis Using Wearable ECGCompletedNCT070549051 country
- A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of HyperkalaemiaTerminatedNCT05056727Phase 321 countries
- A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in GreeceCompletedNCT061856601 country
- IMpact of hyPeRkalaemia on thErapy With Renin angiotenSin aldoSterone System InhibitorsWithdrawnNCT045107921 country
- 5 Versus 10 Units of Insulin in Hyperkalemia ManagementCompletedNCT06036823Phase 41 country
- Nurse-Led Nutritional Education for Moroccan Dialysis PatientsCompletedNCT07277530Not applicable1 country
- Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge StudyCompletedNCT05347693Phase 46 countries
- An Observational Prospective Cohort Study for Long-term Management of Hyperkalemia in Patients With Chronic Kidney Disease or Heart FailureCompletedNCT052974091 country
- Tracking Treatment Pathways in Adult Patients With Hyperkalemia.CompletedNCT054080395 countries
- Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving SpironolactoneCompletedNCT04676646Phase 48 countries
- OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart FailureActive, not recruitingNCT04789239Phase 21 country
- Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)TerminatedNCT04847232Phase 326 countries
- The ORTIZ Study: Optimising RASi Therapy With SZCTerminatedNCT04983979Phase 21 country
- Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease PatientsCompletedNCT03781089Phase 41 country
- A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia.CompletedNCT03528681Phase 32 countries
- Targeted Potassium Levels for Prevention of ICD TherapyActive, not recruitingNCT03833089Phase 41 country