Hyperinsulinism: all 110 studies

Page 1 of 2. Open to participants first (22), then studies with results posted, then the rest; newest registration first within each.

• Umbilical Cord GlucoseNot yet recruitingNCT07795047Not applicable
• Alpelisib Challenge Test (ACT)RecruitingNCT07778524Phase 1
• Application of FreeStyle Libre 2 for Evaluating Glycemic Variability Characteristics in Patients With Extreme Glucose Metabolism PhenotypesNot yet recruitingNCT07564518
• Effect of Insulin Lowering on LipogenesisRecruitingNCT07403604Phase 1
• Intermediate-Size Cohort EAP for Ersodetug in Patients With Inadequately Controlled Hypoglycemia Related to a TumorAvailableNCT07262970
• Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOSRecruitingNCT06889454
• A Phase 3 Study of Ersodetug in Patients With Tumor HyperinsulinismRecruitingNCT06881992Phase 3
• Human Models of Selective Insulin Resistance: Pancreatic ClampNot yet recruitingNCT06558422Phase 1
• Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)RecruitingNCT06478121
• The Movie Theater StudyRecruitingNCT06444984Not applicable
• Human Models of Selective Insulin Resistance: Alpelisib, Part IRecruitingNCT06354088Phase 1
• Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound RadiomicsRecruitingNCT06343974
• Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant TherapyRecruitingNCT05989347Phase 1
• Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS DiagnosisRecruitingNCT05950282
• A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.RecruitingNCT05753657Early Phase 1
• Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes MellitusRecruitingNCT05662189Not applicable
• Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 DiabetesRecruitingNCT05543083Not applicable
• Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast CancerRecruitingNCT05455619Phase 1/2
• Utility of 18FDOPA PET/MRI for Focal HyperinsulinismRecruitingNCT05088798Phase 2
• Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksRecruitingNCT03374215
• Fluorodopa F 18 in Congenital Hyperinsulinism and InsulinomaRecruitingNCT02021604Phase 1
• 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic HypoglycemiaAvailableNCT01916148
• Glycemic Effect of Diazoxide in NAFLDCompletedNCT05729282Phase 1Results posted
• An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital HyperinsulinismCompletedNCT04538989Phase 2Results posted
• Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital HyperinsulinismCompletedNCT04172441Phase 2/3Results posted
• A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 DiabetesCompletedNCT04118374Not applicableResults posted
• Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia SyndromeCompletedNCT03797222Not applicableResults posted
• A Two-Period Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital HyperinsulinismCompletedNCT03777176Phase 3Results posted
• Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy DiabetesCompletedNCT03303196Not applicableResults posted
• Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)CompletedNCT02971202Phase 1Results posted
• CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital HyperinsulinismCompletedNCT02937558Phase 2Results posted
• Reprometabolic Syndrome Mediates Subfertility in ObesityActive, not recruitingNCT02653092Not applicableResults posted
• PK/PD Study of U-500 Regular InsulinCompletedNCT02148250Phase 2Results posted
• Phase II Safety and Efficacy Study of 18FDOPA PET-CT in Children With Hyperinsulinemic HypoglycemiaCompletedNCT01468454Phase 2Results posted
• Maternal Lifestyle and Neonatal HypoglycemiaCompletedNCT01409382Not applicableResults posted
• Effect of Exendin-(9-39) on Fasting Adaptation and Protein SensitivityCompletedNCT00897676Phase 1/2Results posted
• Effect of Exendin (9-39) on Glucose Requirements to Maintain EuglycemiaTerminatedNCT00835328Phase 1/2Results posted
• Utility of [F-18] fluoroDOPA for Neonatal HyperinsulinismCompletedNCT00674440Phase 2Results posted
• EMPOWIR:Enhance the Metabolic Profile of Women With Insulin ResistanceCompletedNCT00618072Phase 2Results posted
• Effect of Exendin-(9-39) on Glycemic Control in Subjects With Congenital HyperinsulinismCompletedNCT00571324Phase 1/2Results posted
• Metformin to Treat Obesity in Children With Insulin ResistanceCompletedNCT00005669Phase 2Results posted
• Prevalenza Della Insulino Resistenza e Correlate Malattie Cardiovascolari Nella città di NapoliCompletedNCT07785518
• Effect of a Sugar Replacement on Blood Glucose Levels in Healthy AdultsActive, not recruitingNCT06714552Not applicable
• Diazoxide Suppression Test P&F StudyTerminatedNCT06606327Phase 1
• Graded Insulin Suppression Test P&FCompletedNCT06592261Phase 1
• Continuous Glucose Monitoring in Neonatal HyperinsulinismTerminatedNCT06363929
• Effects of Antipsychotics on Brain Insulin Action in FemalesActive, not recruitingNCT06251635Not applicable
• RZ358 Treatment for Congenital HyperinsulinismActive, not recruitingNCT06208215Phase 3
• Dexamethasone/Pancreatic Clamp P&FWithdrawnNCT06126354Phase 1
• Hyperinsulinemia in Prediabetes Mediated by Interleukin-1βCompletedNCT05854251Phase 2
• Effect of Hibiscus Sabdariffa BeverageStatus unknownNCT05774613Not applicable
• Acute Microbial SwitchCompletedNCT05764200Not applicable
• Effect of Alpelisib in Healthy VolunteersCompletedNCT05733455Phase 1
• Pancreatic Clamp in NAFLDCompletedNCT05724134Phase 1
• NUTRACORE, Glycaemic Index and AppetiteCompletedNCT05528874Not applicable
• Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and HyperinsulinemiaCompletedNCT05329337Not applicable
• Developing a Physiological Understanding of High Duration ActivityActive, not recruitingNCT05135234Not applicable
• Time-restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian SyndromeStatus unknownNCT05126199Not applicable
• Increasing Insulin Resistance as a Predictor of Impending BacteremiaCompletedNCT04992689
• Vitamin E Efficacy in HI/HAWithdrawnNCT04984798Phase 2
• Exenatide-test for Diagnosing Endogenous Hyperinsulinemic HypoglycemiaCompletedNCT04909333Not applicable
• Exercise Type That Faster Reduces Postprandial Glycemia.Status unknownNCT04846751Not applicable
• Effects Of Combined Cryolipolysis And High Intensity Interval Training On Insulin Resistance And Body Composition In Polycystic Ovarian PatientsStatus unknownNCT04744896Not applicable
• To Compare the Effects of Non-nutritive Sweeteners Intake in Woman With Insulin ResistanceCompletedNCT04327245Not applicable
• Saliva Insulin Responses to a Standardized Meal Tolerance Test in HumansStatus unknownNCT04309071Not applicable
• Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin ResistanceWithdrawnNCT04062890Phase 2
• The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial LipemiaCompletedNCT03856606Not applicable
• GLP-1 Receptor Expression in CHIStatus unknownNCT03768518
• The Effect of Andrographis Paniculata to GLP-1, Fasting Insulin, Insulin 2-h Post OGTT, and HOMA-IRCompletedNCT03455049Not applicable
• Impact of Meal Order on Postprandial Cardiometabolic Risk MarkersCompletedNCT03358745Not applicable
• Pasireotide in Hyperinsulinemic HypoglycemiaWithdrawnNCT03053284Phase 2
• 18F-DOPA PET Imaging: an Evaluation of Biodistribution and SafetyCompletedNCT03042416Phase 3
• Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric HypoglycemiaCompletedNCT02996812Phase 1
• A Cold Physical Treatment to Manage Insulin ResistanceCompletedNCT02852759Not applicable
• Compassionate Use of SOM230 for Hyperinsulinemic/HypoglycemiaNo longer availableNCT02835131
• Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?CompletedNCT02665715Not applicable
• Natriuretic Peptides and Metabolic Risk in ObesityWithdrawnNCT02642523Early Phase 1
• A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital HyperinsulinismCompletedNCT02604485Phase 2
• Study of the Use of [18F]-DOPA in Hyperinsulinemic HypoglycemiaNo longer availableNCT02533219
• Sirolimus for the Treatment of HyperinsulinismWithdrawnNCT02524639Phase 1/2
• Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With DiabetesCompletedNCT02248272Not applicable
• Towards Individualized Surgery in Non-focal Congenital HyperinsulinismCompletedNCT02108730
• Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining NormoglycemiaWithdrawnNCT02032953Phase 4
• Long Term Glucose Metabolism in Conservatively Treated Patients With Congenital HyperinsulinismStatus unknownNCT01819584
• The Effect of Metformin on the Correlation Between Hyperinsulinemia and HypertensionCompletedNCT01342614Not applicable
• Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With HyperinsulinemiaCompletedNCT01125150
• Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of InfancyCompletedNCT01070758Phase 4
• Sandostatine® LP and HyperinsulinismCompletedNCT00987168Phase 2
• Whole Body 111In-exendin-4 Imaging Study in Insulinoma PatientsCompletedNCT00937079
• Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose ToleranceCompletedNCT00667498Phase 4
• DZX Mediated Insulin Suppression in Obese MenCompletedNCT00631033Phase 2
• VLDL-triglyceride Under Acute HyperinsulinaemiaCompletedNCT00624104
• Effects of a Comprehensive Weight Management Program on Obese Adolescents and ChildrenCompletedNCT00409422Not applicable
• Blood Sugars in Children With Idiopathic Seizures.WithdrawnNCT00279851
• Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese MenCompletedNCT00151684Phase 2
• Genomewide Search for Loci Underlying Metabolic SyndromeCompletedNCT00074451
• Epidemiology of Stress and the Metabolic SyndromeCompletedNCT00073775
• Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 DiabetesCompletedNCT00065676Phase 2
• Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat AbnormalitiesCompletedNCT00015691Not applicable
• Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 DiabetesCompletedNCT00005760

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