A Phase 4 interventional study of Travasol (amino acid injection) and Insulin in Colorectal Cancer, sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre. Withdrawn at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre · Phase 4, Interventional, and Treatment
The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by increasing the amount of protein given.
5,734 studies on the registry are indexed under Colorectal Neoplasms; 1,481 are open to participants now.
Browse Colorectal Neoplasms studies →McGill University Health Centre/Research Institute of the McGill University Health Centre is the lead sponsor of 420 studies on the registry; 106 are open to participants now.
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Exclusion Criteria:
Insulin (hyperinsulinemic-normoglycemic clamp) with Travasol (amino acid supplementation) given from start of surgery to 6 hours after, at an amount of 35% of patient's energy expenditure as measured before surgery, .
Dietary Supplement: Travasol (amino acid injection) · Drug: Insulin
Insulin (hyperinsulinemic-normoglycemic clamp) with Travasol (amino acid infusion), given from start of surgery to 6 hours after, at an amount of 20% of patient's energy expenditure as measured before surgery.
Dietary Supplement: Travasol (amino acid injection) · Drug: Insulin
Insulin (hyperinsulinemic-normoglycemic clamp, an insulin infusion between 2 and 5 microunits/kg with glucose at a variable rated titrated to maintain normoglycemia, blood glucose 4-6 mmol/L) with no protein supplementation from start of surgery to 6 hours after.
Drug: Insulin
an amino acid supplementation infused intravenously containing essential and non-essential amino acids
Also known as: Travasol
After the insertion of an arterial catheter and obtaining a baseline arterial blood glucose value, 2 units of insluin will be administered iv followed by an infusion of 2 microunits/kg\*min. Ten minuts after starting the insulin, and when the the blood glucose is\<6 mmol/L, dextrose 20% supplemented with phosphate (30mmol/L) will be infused. Blood glucose levels measured every 15 minutes and the dextrose infusion rate adjusted to maintain arterial glycemia between 4 and 6 mmol/L until end of study.
Also known as: HNC, Hyperinsulinemic-normoglycemic clamp
Net protein balance
The difference in total body protein after randomization to one of the three treatment arms.
Time frame: 6 hours after surgery
The record gives a start of Dec 2013, a primary completion of Apr 2024 and a completion of Apr 2024. It does not say whether these dates are actual or estimated.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is withdrawn, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.
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McGill University Health Centre/Research Institute of the McGill University Health Centre →