Fractures, Open clinical trials

The registry lists 53 studies for Fractures, Open across more than 10 countries. 14 are recruiting or about to start. 31 of them are mainly about Fractures, Open (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 22
Status unknown: 9
Recruiting: 8
Terminated: 8
Not yet recruiting: 5
Enrolling by invitation: 1

Phase

Phase 4: 14
Phase 3: 6
Phase 2: 1

Where

United States: 28
Canada: 8
United Kingdom: 3
Thailand: 3
Israel: 2
France: 2

Who runs them

Assiut University (3) · McMaster University (3) · Dartmouth-Hitchcock Medical Center (2) · Olayemi Osiyemi MD (2) · University of Maryland, Baltimore (2) · Major Extremity Trauma Research Consortium (2) · Oxford University Hospitals NHS Trust (2) · The First Affiliated Hospital of Dalian Medical University (1)

What is being tested here

Drugs under test in Fractures, Open studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Vancomycin	2	0	4
Cephalexin	1	0	1
Sodium Chloride	1	0	1
Tobramycin	0	2	3
DuraPrep	0	0	1
Chlorhexidine/Ethyl Alcohol Mouthwash	0	0	1
Oxycodone	0	0	1
Ceftriaxone	0	0	1
Ampicillin	0	0	1
Sulbactam	0	0	1

Coming up

1phase 3 study under way

4studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 4, phase 3 first

Dec 2026Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures · Phase 3 · Atlantic Health System
Nov 2026SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol · University of Birmingham
Jun 2027The Treatment of Type I Open Fractures in Pediatrics · Ann & Robert H Lurie Children's Hospital of Chicago
Sep 2027Placement of Antibiotic Powder in Wounds During the Emergency Room · The University of Texas Health Science Center at San Antonio

Who these studies take

Of the 8 Fractures, Open studies recruiting now, 5 (63%) set no upper age limit and 2 (25%) stop at 75 or younger. 3 (38%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 8
Age	Women	Men
10	3 (38%)	3 (38%)
18	7 (88%)	7 (88%)
30	7 (88%)	7 (88%)
40	7 (88%)	7 (88%)
50	7 (88%)	7 (88%)
65	7 (88%)	7 (88%)
75	6 (75%)	6 (75%)
85	6 (75%)	6 (75%)

Across all 53 studies, recruiting or not: 25% stop at 75 or younger and 17% at 65; 23% take children; 0% are for women only and 0% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 11, 2026.

Newly registered1

Local Antibiotic Delivery From an Intramedullary Nail After Surgical Treatment of Tibial Fractures at High Risk of InfectionNov 10, 2026NCT07927166

Studies

Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.