A Phase 3 interventional study of Vancomycin (VAN) treatment and Standard Open Fracture Care in Open Fracture, sponsored by Atlantic Health System. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-22.
Sponsored by Atlantic Health System · Phase 3, Interventional, and Prevention
To evaluate the feasibility, safety, and potential efficacy of applying vancomycin powder locally to open fractures in the emergency department prior to definitive surgical intervention.
53 studies on the registry are indexed under Fractures, Open; 14 are open to participants now.
This study's planned enrollment of 100 is above the median of 90 across 40 interventional studies indexed under Fractures, Open.
Browse Fractures, Open studies →Atlantic Health System is the lead sponsor of 64 studies on the registry; 12 are open to participants now.
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Exclusion Criteria:
Patients receive 1 gram topical vancomycin powder applied to the open fracture wound in the Emergency Department in addition to standard open fracture management.
Drug: Vancomycin (VAN) treatment
Patients receive standard open fracture management without Emergency Department (ED) vancomycin powder.
Other: Standard Open Fracture Care
A single 1-gram dose of sterile vancomycin powder is applied directly to the open fracture wound in the Emergency Department after initial wound assessment and irrigation and prior to definitive operative debridement and fixation.
Standard management of open fractures according to institutional protocols, including intravenous antibiotics, wound care, irrigation, operative debridement, and fracture stabilization as indicated, without topical vancomycin powder application in the Emergency Department.
Deep Surgical Site Infection
Incidence of deep surgical site infection following open fracture treatment, defined according to Centers for Disease Control and Prevention (CDC)/National Healthcare Safety Network (NHSN) criteria and/or requiring operative irrigation and debridement or deep culture-directed antibiotic treatment.
Time frame: Defined as the proportion of participants who develop a deep surgical site infection involving the open fracture site within 90 days of injury or index operative treatment.
Plan to share: No — Data will be collected and stored locally, de-identified, and deleted after study completion
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Atlantic Health System