Cigarette Smoking clinical trials
The registry lists 475 studies for Cigarette Smoking across more than 10 countries. 86 are recruiting or about to start. 300 of them are mainly about Cigarette Smoking (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
Get an email when these change. Save the Cigarette Smoking studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Duke University (27) · Medical University of South Carolina (15) · Virginia Polytechnic Institute and State University (15) · Ohio State University Comprehensive Cancer Center (14) · Yale University (13) · University of California, San Francisco (12) · Abramson Cancer Center at Penn Medicine (10) · University of Oklahoma (10)
What is being tested here
Drugs under test in Cigarette Smoking studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Nicotine | 3 | 4 | 20 |
| Semaglutide | 2 | 0 | 3 |
| Varenicline | 1 | 3 | 20 |
| Nicotine Patch | 1 | 2 | 10 |
| Nicotine Lozenge | 1 | 0 | 3 |
| Propranolol | 1 | 0 | 2 |
| Nicotine Chewing Gum | 1 | 0 | 1 |
| Trichlorosucrose | 1 | 0 | 1 |
| Tetrahydrocannabivarin | 1 | 0 | 1 |
| NOS F-18 | 1 | 0 | 1 |
Drug classes tested here GLP-1 receptor agonists 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Optimizing Tobacco Use Treatment for PLWHA · Phase 3 · Abramson Cancer Center at Penn Medicine
- Apr 2027Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
- Nov 2026Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches · Medical University of South Carolina
- Nov 2026THE EFFECT OF A TRANSTHEORETICAL MODEL-BASED CHATBOT SUPPORT INTERVENTION ON SMOKING BEHAVIOR IN UNIVERSITY STUDENTS · Seher DÖNER
- Nov 2026ACT Lung Health Intervention: Phase Two · Dana-Farber Cancer Institute
- Nov 2026Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking Cessation · Johns Hopkins Bloomberg School of Public Health
- Dec 2026A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product · RAI Services Company
- Dec 2026A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products · RAI Services Company
- Dec 2026Effectiveness of Brief Smoking Cessation Counselling in Pre-Anaesthesia Assessment Clinic · Pok Oi Hospital
- Dec 2026Cardiovascular Effects of Very Low Nicotine Content Cigarettes · Wake Forest University Health Sciences
Who these studies take
Of the 61 Cigarette Smoking studies recruiting now, 38 (62%) set no upper age limit and 17 (28%) stop at 75 or younger. 1 (2%) take children under 18. 4 (7%) are for women only and 2 (3%) for men only; 32 (52%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 25 (41%) | 22 (36%) |
| 30 | 53 (87%) | 51 (84%) |
| 40 | 52 (85%) | 51 (84%) |
| 50 | 53 (87%) | 52 (85%) |
| 65 | 50 (82%) | 48 (79%) |
| 75 | 45 (74%) | 43 (70%) |
| 85 | 41 (67%) | 39 (64%) |
Across all 475 studies, recruiting or not: 51% stop at 75 or younger and 45% at 65; 4% take children; 4% are for women only and 3% for men only; 57% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cigarette Smoking studies take
Of 27 phase 2 interventional studies under Cigarette Smoking, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 16 mo8–29 · 19 studies | — | — |
| Phase 2 | 33 mo16–43 · 27 studies | — | — |
| Interventional, no phase | 20 mo9–32 · 191 studies | — | 20 mo9–33 · 184 studies |
| Observational | 24 mo11–45 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Generalized and Domain-Specific Episodic Thinking for Smoking CessationOct 13, 2026NCT07158749
Newly registered6
- Impacto 2.0: Mobile Smoking Cessation Across TexasNov 4, 2026NCT07915973
- §SMOKE Nicotine and Tobacco Youth CohortNov 2, 2026NCT07910331
- Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.Oct 27, 2026NCT07897058
- THE EFFECT OF A TRANSTHEORETICAL MODEL-BASED CHATBOT SUPPORT INTERVENTION ON SMOKING BEHAVIOR IN UNIVERSITY STUDENTSOct 21, 2026NCT07887217
- A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System ProductOct 20, 2026NCT07881848
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Studies
Recruiting first, then most recently updated. Showing 50 of 475. Browse all 475 → or search them.
- E-Cigarettes for Harm Reduction in Smokers With Opioid Use DisorderRecruitingNCT05722561Phase 21 country
- §SMOKE Nicotine and Tobacco Youth CohortRecruitingNCT079103311 country
- Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and MaintenanceRecruitingNCT074394711 country
- Remote Interventions for Menthol Cigarette UseNot yet recruitingNCT07356297Not applicable
- Impacto 2.0: Mobile Smoking Cessation Across TexasNot yet recruitingNCT07915973Not applicable1 country
- PK/PD of Vaping THC-containing Liquids vs. Smoked CannabisNot yet recruitingNCT06055231Phase 1
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based ProgramRecruitingNCT05008848Phase 31 country
- iCanQuit Smoking Cessation Among Hispanic AdultsNot yet recruitingNCT06811038Phase 31 country
- Studying Different Ways of Using Oral Nicotine Pouches to Understand the Effect on Nicotine Delivery, Appeal, and Side Effects Among Adult Cigarette SmokersNot yet recruitingNCT07899827Not applicable1 country
- Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking AdultsRecruitingNCT06816459Early Phase 11 country
- A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska Natives, NAITIVE TrialNot yet recruitingNCT06697496Not applicable1 country
- A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System ProductNot yet recruitingNCT07881848Not applicable
- Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking CessationNot yet recruitingNCT07789496Not applicable1 country
- Generalized and Domain-Specific Episodic Thinking for Smoking CessationRecruitingNCT07158749Not applicable1 country
- Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I TrialRecruitingNCT04604509Phase 41 country
- Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES TrialRecruitingNCT07604246Not applicable1 country
- Ecological Momentary Assessment of Smoking Triggers, Needs, and Cigarette ForgoingNot yet recruitingNCT07852845Not applicable
- E-cigarettes for Harm Reduction Among Smokers With Serious Mental IllnessRecruitingNCT05815199Not applicable1 country
- Imaging Sex Differences in Smoking-Induced Pulmonary InflammationRecruitingNCT03721822Phase 11 country
- Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation TrialNot yet recruitingNCT07835555Phase 41 country
- Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)RecruitingNCT07711691Not applicable1 country
- Semaglutide for Post-Smoking Cessation Weight ManagementRecruitingNCT06173778Phase 21 country
- Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use TreatmentNot yet recruitingNCT07809854Phase 41 country
- Trauma-Informed Care for Smoking Cessation for PregnancyRecruitingNCT07129590Not applicable1 country
- Varenicline for Smoking Reduction in Veterans Not Ready To QuitRecruitingNCT06966362Phase 41 country
- Impact of Sweeteners on the Addictive Threshold of NicotineNot yet recruitingNCT07771725Phase 11 country
- Cardiovascular Effects of Very Low Nicotine Content CigarettesRecruitingNCT05707871Early Phase 11 country
- A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free HomeRecruitingNCT06693700Not applicable1 country
- Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use DisorderNot yet recruitingNCT07770555Not applicable1 country
- Evaluation of Low and High Nicotine Tobacco Free Nicotine PouchesRecruitingNCT06678789Not applicable1 country
- A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit TrialRecruitingNCT06145763Not applicable1 country
- A Behavioral Application for Improving Smoking Cessation Among SmokersNot yet recruitingNCT07493252Not applicable1 country
- A Clinical Trial of Adaptive Treatment for Early Smoking Cessation RelapseRecruitingNCT06118502Not applicable1 country
- Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South KoreaNot yet recruitingNCT07755891Not applicable1 country
- THCV Treatment for SmokersNot yet recruitingNCT07636356Phase 2
- A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System ProductsNot yet recruitingNCT07739797Not applicable
- Maternal Smoking Cessation and Pediatric Obesity PreventionRecruitingNCT03514602Not applicable1 country
- Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy SmokersRecruitingNCT05121051Phase 21 country
- Switch or Quit R01RecruitingNCT06373679Not applicable1 country
- Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for SmokingEnrolling by invitationNCT07625956Phase 41 country
- Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural AppalachiaRecruitingNCT06763536Not applicable1 country
- 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use DisorderRecruitingNCT05452772Phase 21 country
- Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking CessationRecruitingNCT05836103Not applicable1 country
- PASCAL Feasibility StudyRecruitingNCT07301151Not applicable1 country
- Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding PromotionRecruitingNCT07661550Not applicable1 country
- Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to QuitRecruitingNCT07199517Not applicable1 country
- Cigarette Filter StudyRecruitingNCT07348679Not applicable1 country
- GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIVRecruitingNCT07221214Phase 21 country
- The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded StudyRecruitingNCT065358671 country
- Effects of Tax Proposals and Cigarette Availability on Tobacco PurchasingRecruitingNCT07142668Not applicable1 country