An interventional study of Videoscope-assisted periodontal regeneration minimally invasive surgery and Periodontal regeneration minimally invasive surgery in Chronic Periodontitis, sponsored by University of Illinois at Chicago. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-17.
Sponsored by University of Illinois at Chicago · Not applicable, Interventional, and Treatment
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Although this therapeutic approach is well established in clinical settings and can rescue teeth with poor or questionable prognosis, MIS approaches often suffer from lack of predictability due to poor intraoral visibility of the bony lesion and inability to confirm thorough removal of etiological factors (plaque/calculus) on tooth surfaces. We seek to investigate whether improved visualization of the surgical field using an FDA approved videoscope (V) improves clinical outcomes. For this pilot study, N=50 (to attain 10/group) age, sex matched, systemically healthy subjects diagnosed with Stage III, Grade B periodontitis, formerly known as severe chronic periodontitis, will be randomly assigned to either the VMIS (Test), MIS (Control 1) or Guided Tissue Regeneration (GTR, Control 2) group. All periodontal therapy will be performed following the Standard of Care for periodontal regeneration to determine if utilization of the videoscope improves clinical and radiographic outcomes. We will examine bone fill using conventional digital periapical radiographs (PAR) and Cone Beam Computed Tomography (CBCT) imaging at 6 and 12 months compared to baseline and collect gingival crevicular fluid (GCF) to compare expression of growth factors and cytokines/chemokines during the healing period. This is a single center treatment study where subjects will be recruited from individuals seeking periodontal treatment at the Graduate Periodontics Clinic, UIC College of Dentistry (COD). Participation of all subjects will end after 12 months and will comprise 7 total visits.
378 studies on the registry are indexed under Chronic Periodontitis; 23 are open to participants now.
This study's planned enrollment of 50 is above the median of 45 across 307 interventional studies indexed under Chronic Periodontitis.
Browse Chronic Periodontitis studies →University of Illinois at Chicago is the lead sponsor of 515 studies on the registry; 133 are open to participants now.
Of its 31 completed or terminated interventional studies of FDA-regulated products, 18 (58%) have results posted.
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Individual must be between the age of 18 and 70 years of age
Exclusion Criteria:
Individuals not referred from the Predoctoral Periodontics Student Clinics
Videoscope-assisted periodontal regeneration minimally invasive surgery - Test group
Device: Videoscope-assisted periodontal regeneration minimally invasive surgery
Periodontal regeneration minimally invasive surgery - Control Group 1
Procedure: Periodontal regeneration minimally invasive surgery
Guided tissue regeneration - Control Group 2
Procedure: Guided tissue regeneration surgery
Use of a videoscope to improve visualization of periodontal defect during minimally invasive surgery
Conventional periodontal regeneration minimally invasive surgery without use of a videoscope
Conventional guided tissue regeneration surgery for periodontal regeneration without use of a videoscope
Clinical Attachment Level
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Time frame: 6 months
Probing Depth (PD)
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Time frame: 6 months
Gingival Recession (GR)
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Time frame: 6 months
Radiographic Bone Height (RBH)
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Time frame: 6 months
Radiographic Bone Volume (RBV)
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
Time frame: 6 months
Clinical Attachment Level
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Time frame: 12 months
Probing Depth (PD)
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Time frame: 12 months
Gingival Recession (GR)
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Time frame: 12 months
Radiographic Bone Height (RBH)
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Time frame: 12 months
Radiographic Bone Volume (RBV)
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
Time frame: 12 months
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Concentration of 24 cytokines, chemokines, and growth factors in gingival crevicular fluid (GCF) measured in pg/mL.
Time frame: 6 months
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Concentration of 24 cytokines, chemokines, and growth factors in gingival crevicular fluid (GCF) measured in pg/mL.
Time frame: 12 months
Plan to share: No
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This study is active, not recruiting, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.
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University of Illinois at Chicago