An interventional study of Enamel Matrix Derivative in Dental Implantation, Missing Teeth and Periodontitis, Adult, sponsored by The University of Texas Health Science Center at San Antonio. Recruiting at 1 site in United States. Open to participants aged 18 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-12.
Sponsored by The University of Texas Health Science Center at San Antonio · Not applicable, Interventional, and Treatment
Scientists do research to answer important questions which might help change or improve the way we do things in the future.
The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth. This study will test to see if using EMD around implants results in thicker gum tissues around implants.
The hypothesis of the study is that the addition of EMD under the gingival flap prior to suturing will result in increased mucosal tissue thickness and increased keratinized tissue width as compared to not using the EMD.
The EMD will be deposited under the mucosal flap during the second stage implant uncovering. After flap suturing, an intraoral scan will be obtained. This procedure will require approximately 5 - 10 minutes per patient. All patients will be followed up at 14 days for suture removal per standard of care and not as part of the study. All patients will be followed up at one and three months per standard of care during which visits they will undergo an intraoral scan to allow evaluation of soft tissue dimensions. This is research only procedure that is expected to add 5 - 10 minutes to the regular postoperative visit. Study participation will be completed at the 3-month visit.
85 studies on the registry are indexed under Anodontia; 22 are open to participants now.
This study's planned enrollment of 32 is close to the median of 30 across 61 interventional studies indexed under Anodontia.
Browse Anodontia studies →The University of Texas Health Science Center at San Antonio is the lead sponsor of 435 studies on the registry; 88 are open to participants now.
Of its 62 completed or terminated interventional studies of FDA-regulated products, 31 (50%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
During implant uncovering the experimental group will receive EMD under the buccal flap
Device: Enamel Matrix Derivative
No EMD is administered under the buccal flap during suturing
EMD is an FDA approved medical device used in periodontal procedures since 1996. It has been shown to enhance soft and hard tissue healing, increased root coverage and aid in periodontal regeneration. It's use as an adjunct during implant uncovering may increase peri-implant mucosal thickness.
Also known as: EMD
Mucosal Thickness
Mucosal thickness at 1 and 5mm below the free gingival margin will be measured
Time frame: One month and 3 months
Change in Keratinized mucosal width
measurement of keratinized mucosal width at one and three months after surgical uncovering of the dental implant
Time frame: One month and 3 months
Plan to share: Yes — The PI will ensure all mechanisms used to share data will include proper plans and safeguards for the protection of privacy, confidentiality, and security for data dissemination and reuse (e.g., all data will be thoroughly de-identified and will not be traceable to a specific study participant). Plans for archiving and long-term preservation of the data will be implemented as appropriate.
Supporting information: Study protocol, Sap
No publications or documents are linked to this record.
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The University of Texas Health Science Center at San Antonio