Cerebral Small Vessel Diseases clinical trials
The registry lists 128 studies for Cerebral Small Vessel Diseases across more than 10 countries. 71 are recruiting or about to start. 77 of them are mainly about Cerebral Small Vessel Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 6 narrower conditions too, such as Fabry Disease: 514 studies, 160 open.
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Who runs them
Beijing Tiantan Hospital (10) · Zeng Changhao (5) · Assistance Publique - Hôpitaux de Paris (4) · Chinese University of Hong Kong (4) · University of Edinburgh (4) · Ain Shams University (3) · Zhejiang Provincial People's Hospital (3) · RenJi Hospital (3)
What is being tested here
Drugs under test in Cerebral Small Vessel Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cilostazol | 2 | 1 | 5 |
| Lidocaine | 2 | 0 | 3 |
| Isosorbide mononitrate | 1 | 2 | 3 |
| Butylphthalide | 1 | 1 | 2 |
| Songling xuemaikang | 1 | 0 | 1 |
| Tongxinluo | 1 | 0 | 1 |
| Ezetimibe | 1 | 0 | 1 |
| PCSK9 Inhibitor | 1 | 0 | 1 |
| GLP-1 Mimetic | 1 | 0 | 1 |
| Semaglutide | 1 | 0 | 1 |
Drug classes tested here PDE5 inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Aug 2027Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) · Phase 3 · Beijing Tiantan Hospital
- Oct 2027Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel Disease · Phase 3 · Peking Union Medical College Hospital
- Nov 2026Neural Correlates (EEG and fMRI) of Gait in Small Vessel Disease · Ain Shams University
- Dec 2026Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease · Jiangsu Province Nanjing Brain Hospital
- Dec 2026Songling Xuemaikang Capsules for Cerebral Small Vessel Disease · Dongzhimen Hospital, Beijing
- Dec 2026Taiwan Associated Genetic and Nongenetic Small Vessel Disease · National Taiwan University Hospital
- Dec 2026Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD) · University of L'Aquila
- Mar 2027Imaging the Pathogenesis of Cerebral Small Vessel Disease · Johns Hopkins University
- May 2027GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD) · Chinese University of Hong Kong
- May 2027PUFFINS Brain Health Study · University of Aberdeen
Who these studies take
Of the 46 Cerebral Small Vessel Diseases studies recruiting now, 26 (57%) set no upper age limit and 5 (11%) stop at 75 or younger. 2 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 11 (24%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (2%) | 1 (2%) |
| 18 | 18 (39%) | 18 (39%) |
| 30 | 25 (54%) | 25 (54%) |
| 40 | 31 (67%) | 31 (67%) |
| 50 | 39 (85%) | 39 (85%) |
| 65 | 45 (98%) | 45 (98%) |
| 75 | 42 (91%) | 42 (91%) |
| 85 | 32 (70%) | 32 (70%) |
Across all 128 studies, recruiting or not: 14% stop at 75 or younger and 5% at 65; 4% take children; 1% are for women only and 0% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic StrokeNov 12, 2026NCT07903922
Newly registered3
- Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic StrokeOct 29, 2026NCT07903922
- Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel DiseaseOct 23, 2026NCT07891650
- Outcome Prediction and Recovery After Spontaneous Intracerebral HaemorrhageOct 20, 2026NCT07882784
Studies
Recruiting first, then most recently updated. Showing 50 of 128. Browse all 128 → or search them.
- Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic StrokeRecruitingNCT079039221 country
- Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel DiseaseRecruitingNCT06674460Phase 31 country
- Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel DiseaseNot yet recruitingNCT07891650Not applicable1 country
- Outcome Prediction and Recovery After Spontaneous Intracerebral HaemorrhageNot yet recruitingNCT078827842 countries
- Study on Eye-Brain Cross-Organ Mapping and Systemic Disease Association Based on Multimodal Big DataNot yet recruitingNCT07541651
- Dementia Risk Registry Across the Multidimensional Lifespan: A 10-Year StudyRecruitingNCT061642621 country
- Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion StrokeRecruitingNCT06649240Not applicable1 country
- Retina is a Marker for Cerebrovascular HeathRecruitingNCT04753970Phase 1/21 country
- The Longitudinal Cohort of Cerebral Small Vessel Disease in Ruijin HospitalNot yet recruitingNCT077266541 country
- GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)RecruitingNCT05356104Phase 22 countries
- MRI-Based Lesion Differentiation in Older Patients With Multiple SclerosisRecruitingNCT074440471 country
- Cerebral Small Vessel Disease Progression Dependent on Stroke TypeRecruitingNCT076111361 country
- Severe Congenital Hemostatic Defects, Cerebral MIcrobleeds and COGnitionRecruitingNCT060902011 country
- Long-term Prospective Study of Korean CADASIL PatientsRecruitingNCT074978671 country
- PUFFINS Brain Health StudyRecruitingNCT069478761 country
- Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant AdaptationEnrolling by invitationNCT07503301Not applicable1 country
- Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel DiseaseNot yet recruitingNCT07317557Not applicable1 country
- Retinal Vessel Leakage in Cerebral Small Vessel DiseaseRecruitingNCT064163711 country
- Imaging the Pathogenesis of Cerebral Small Vessel DiseaseRecruitingNCT057033861 country
- Neural Correlates (EEG and fMRI) of Gait in Small Vessel DiseaseNot yet recruitingNCT073729371 country
- Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophysRecruitingNCT07068620Not applicable1 country
- VR Training to Improve Postoperative Cognitive Function in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac SurgeryNot yet recruitingNCT07370844Not applicable1 country
- Taiwan Associated Genetic and Nongenetic Small Vessel DiseaseRecruitingNCT054736371 country
- Registry Study of Cerebral Small Vessel DiseaseRecruitingNCT073420751 country
- Targeting Neurovascular Coupling in Cognitive Decline Via Nitrate-Based SupplementationRecruitingNCT07329647Not applicable1 country
- Songling Xuemaikang Capsules for Cerebral Small Vessel DiseaseNot yet recruitingNCT07271732Not applicable1 country
- Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD)RecruitingNCT06525987Not applicable1 country
- Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT)Not yet recruitingNCT07252544Phase 3
- A Multicenter, Randomized, Double-blind, Placebo-controlled Trial on the Treatment of Hypertensive Intracerebral Hemorrhage With Naoxuekang Dropping PillsNot yet recruitingNCT07200921Phase 21 country
- Prevention of Stroke Recurrence and Disease Progression in Cerebral Small Vessel Disease With CilostazolNot yet recruitingNCT07180472Phase 4
- Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel DiseaseRecruitingNCT06579664Not applicable1 country
- Biomarkers, Risk Assessment, Imaging, and Neurodegeneration in Cerebral Small Vessel Disease (BRAIN-CSVD)Not yet recruitingNCT07093515
- Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac SurgeryNot yet recruitingNCT06999668Not applicable1 country
- WHIte MAtter Hyperintensity Shape and GlymphaticsRecruitingNCT060105111 country
- Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel DiseasesRecruitingNCT067150071 country
- Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASILNot yet recruitingNCT06859658
- 4D-310 in Adults With Fabry Disease and Cardiac InvolvementRecruitingNCT05629559Phase 1/22 countries
- Revascularization Effect on CSVD Burden in Carotid Artery StenosisRecruitingNCT060316101 country
- Correlation Between Deep Medullary Veins and Cognitive Dysfunction in Cerebral Small Vessel DiseaseRecruitingNCT057157101 country
- PRospective Observation on CErebral microvaScular Structure and FunctionRecruitingNCT065796771 country
- Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke CareEnrolling by invitationNCT05967728Phase 21 country
- Intelligent Analysis and Clinical Validation of Cerebral Small Vessel Disease on Magnetic Resonance Imaging：A Multi-center StudyNot yet recruitingNCT066676351 country
- Targeting 18kDa Translocator Protein (TSPO) to Improve Brain Endothelial Cell Function in Cerebral Small Vessel DiseaseRecruitingNCT06643013Not applicable1 country
- Efficacy and Safety of Calculus Bovis Sativus (CBS) for Ischemic Cerebral Vascular Disease (CBSinICVD)RecruitingNCT06474507Not applicable1 country
- Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel DiseaseRecruitingNCT056776071 country
- Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel DiseaseRecruitingNCT064317111 country
- The Effect of Anthocyanin Intake From Purple Sweet Potato in Cerebral Small Vessel DiseaseNot yet recruitingNCT06380465Not applicable
- Study On the Expression Level and Clinical Significance of VISTA in Patients With Vascular Cognitive ImpairmentRecruitingNCT063426611 country
- Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease PatientsNot yet recruitingNCT06328842Not applicable
- Stellate Ganglion Block in Patients With Cerebral Small Vessel DiseaseNot yet recruitingNCT06319495Not applicable