An observational study in Cataract, Vitreous Hemorrhage and Diabetic Eye Diseases, sponsored by Beijing Friendship Hospital. Not yet recruiting. Per ClinicalTrials.gov, last updated 2026-04-21.
Sponsored by Beijing Friendship Hospital · Observational
This project integrates multimodal eye data (CFP, OCT, OCTA) from 50,000 cases, brain MR data from 150,000 cases, and ICD diagnoses, medical orders, and test results from an eye-brain paired cohort of 8,000 cases to construct an eye-brain cross-modal mapping model and an eye-brain-systemic disease association model. It aims to clarify the quantitative associations between multimodal ocular features and brain structural and vascular characteristics as well as systemic disease ICD diagnoses, thereby uncovering the cross-organ and cross-modal linkage mechanisms between the eye and brain. Ultimately, it seeks to achieve mapping and prediction of brain imaging features based on ocular data, enable ocular-based diagnosis and prediction of various diseases, and contribute significantly to early disease screening, risk stratification, and optimization of clinical diagnosis and treatment.
1,701 studies on the registry are indexed under Cataract; 230 are open to participants now.
This study's planned enrollment of 208,000 is above the median of 81 across 484 observational studies indexed under Cataract.
Browse Cataract studies →Beijing Friendship Hospital is the lead sponsor of 216 studies on the registry; 95 are open to participants now.
Counted across the registry records on this site, refreshed daily.
(1) Ophthalmic Data Cohort: Patients and health check-up participants who underwent CFP , OCT or OCTA examinations at Beijing Friendship Hospital, Capital Medical University, from January 2009 to September 2025.(2) Cerebral Data Cohort: Patients and health check-up participants who underwent cerebral MR (Magnetic Resonance) examinations at the same hospital during the corresponding period.(3) Oculo-Cerebral Matched Cohort: Individuals from Beijing Friendship Hospital, Capital Medical University and the UK Biobank (UKB) database who had any of the above ophthalmic imaging examinations, plus cerebral MR scans, and could be matched with complete clinical information.(4) Clinical Correlation Cohort: Individuals from the above cohorts who had complete ICD (International Classification of Diseases) diagnoses, laboratory test results (including blood glucose, blood lipids, uric acid, etc.) and medical order records at Beijing Friendship Hospital, Capital Medical University.
Exclusion Criteria:
Other: No interventions were involved in this study.
Other: No interventions were involved in this study.
Other: No interventions were involved in this study.
Other: No interventions were involved in this study.
No interventions were involved in this study.
Performance of Systemic Disease Prediction Models
Age- and sex-stratified Area Under the Receiver Operating Characteristic Curve (AUC)
Time frame: From the time of model construction and consistency alignment during the study period to the end of the 12-month follow-up after study initiation.
Model generalisation capability.
Evaluated by Cohen's kappa coefficient across external independent cohorts.
Time frame: From the completion of model construction and consistency calibration during the study period to the end of the 12-month follow-up after study initiation.
Eye-Brain Mapping Model Performance.
Measured by correlation coefficient between retinal imaging features and brain neuroimaging metrics.
Time frame: From the completion of model construction and consistency calibration during the study period to the end of the 12-month follow-up after study initiation.
No study locations are listed for this record.
This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Beijing Friendship Hospital