Central Nervous System Diseases clinical trials
The registry lists 386 studies for Central Nervous System Diseases across more than 10 countries. 104 are recruiting or about to start. 32 of them are mainly about Central Nervous System Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 204 narrower conditions too, such as Stroke: 47,519 studies, 11,317 open.
Get an email when these change. Save the Central Nervous System Diseases studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (6) · M.D. Anderson Cancer Center (5) · Eli Lilly and Company (5) · Novartis (5) · Tammie L. S. Benzinger, MD, PhD (5) · Bracco Diagnostics, Inc (4) · Washington University School of Medicine (4) · Danish Headache Center (4)
What is being tested here
Drugs under test in Central Nervous System Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · Dopamine agonists 7 · Antipsychotics 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Aug 2027Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke · Phase 3 · University of Melbourne
- Dec 2026Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer · Stemline Therapeutics, Inc.
- Dec 2026Clinical Evaluation of EEG Device for the Triage of Stroke Patients in the Ambulance · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Dec 2026Video Call Assisted Assessment of Acute Stroke · University of Southern Denmark
- Dec 2026Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke · King Saud University
- Dec 2026PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke · Ludwig-Maximilians - University of Munich
- Dec 2026Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion · Sir Run Run Shaw Hospital
- Jan 2027F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project) · Washington University School of Medicine
- Jan 2027Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia · Advanced Technology & Communications
- Feb 2027Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study · Hospices Civils de Lyon
Who these studies take
Of the 75 Central Nervous System Diseases studies recruiting now, 34 (45%) set no upper age limit and 21 (28%) stop at 75 or younger. 10 (13%) take children under 18. 4 (5%) are for women only and 2 (3%) for men only; 12 (16%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (11%) | 8 (11%) |
| 18 | 51 (68%) | 51 (68%) |
| 30 | 52 (69%) | 52 (69%) |
| 40 | 57 (76%) | 57 (76%) |
| 50 | 62 (83%) | 62 (83%) |
| 65 | 66 (88%) | 66 (88%) |
| 75 | 61 (81%) | 61 (81%) |
| 85 | 45 (60%) | 45 (60%) |
Across all 386 studies, recruiting or not: 29% stop at 75 or younger and 20% at 65; 18% take children; 2% are for women only and 2% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Central Nervous System Diseases studies take
Of 37 phase 2 interventional studies under Central Nervous System Diseases, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 24 mo7–45 · 20 studies | — | — |
| Phase 2 | 28 mo22–44 · 37 studies | — | — |
| Phase 3 | 40 mo21–56 · 17 studies | — | — |
| Interventional, no phase | 38 mo17–58 · 88 studies | — | 39 mo17–58 · 77 studies |
| Observational | 67 mo22–121 · 39 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered4
- Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)Nov 3, 2026NCT07912320
- Register for Medical Data, Functional Scales, and Care Outcomes in ALS, SMA, and Other Motor System DisordersOct 28, 2026NCT07900672
- Effects and Feasibility of a HABIT-ILE and a Home Program on the Bimanual Performance of Children With Cerebral PalsyOct 22, 2026NCT07889622
- Dynamic, Real-world Learning, Innovative Mobility, and Versatile Exploration (DRIVE): Evaluating a Dose-matched Developmental Powered Mobility Intervention for Young Children With Cerebral PalsyOct 15, 2026NCT07876219
Studies
Recruiting first, then most recently updated. Showing 50 of 386. Browse all 386 → or search them.
- Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous SystemRecruitingNCT007943521 country
- Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIIIRecruitingNCT07326566Phase 21 country
- A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease PsychosisRecruitingNCT06887192Phase 215 countries
- An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease PsychosisEnrolling by invitationNCT07459660Phase 23 countries
- A Study to Evaluate the Efficacy, PK, Safety, and Tolerability of VIM0423 in Adults With Parkinson's Disease Tremor Insufficiently Responsive to Dopaminergic TherapyRecruitingNCT07804615Phase 22 countries
- Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)RecruitingNCT068056953 countries
- Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)Enrolling by invitationNCT07912320Not applicable1 country
- A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's DiseaseRecruitingNCT06297590Phase 13 countries
- Register for Medical Data, Functional Scales, and Care Outcomes in ALS, SMA, and Other Motor System DisordersRecruitingNCT079006721 country
- Mixed Reality and Virtual Reality Technology With Mirror Therapy for Stroke RehabilitationRecruitingNCT05903235Not applicable1 country
- Slow-SPEED: Slowing Parkinson's Early Through Exercise DosageRecruitingNCT06993142Not applicable2 countries
- Dynamic, Real-world Learning, Innovative Mobility, and Versatile Exploration (DRIVE): Evaluating a Dose-matched Developmental Powered Mobility Intervention for Young Children With Cerebral PalsyNot yet recruitingNCT07876219Not applicable1 country
- A Long-Term Open-Label Study of ML-007C-MA in Adults With SchizophreniaRecruitingNCT07459647Phase 21 country
- Market Research of a Slow Release Protein Substitute for the Dietary Management of PKUNot yet recruitingNCT07802366Not applicable1 country
- Ear-Seizure Detection (EarSD) StudyRecruitingNCT06598189Not applicable1 country
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy AdultsNot yet recruitingNCT07869654Phase 11 country
- Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast CancerRecruitingNCT05386108Phase 1/210 countries
- Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICURecruitingNCT07219108Not applicable1 country
- Pediatric EpilepsyRecruitingNCT07350551Not applicable1 country
- Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord InjuryRecruitingNCT06330181Not applicable1 country
- Video Call Assisted Assessment of Acute StrokeRecruitingNCT06570681Not applicable1 country
- kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) PilotRecruitingNCT07631078Not applicable1 country
- Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 StudyRecruitingNCT041946191 country
- A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD)Not yet recruitingNCT07832370Phase 1/2
- Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor FunctionRecruitingNCT07056348Not applicable1 country
- Health, Functioning, Work, and Experiences of Social and Health Services of Persons With StrokeEnrolling by invitationNCT065759071 country
- Longitudinal Assessment of Protein Markers in the Cerebrospinal Fluid of Patients With Central Nervous System InvolvementNot yet recruitingNCT073130981 country
- HSV G207 in Children With Recurrent or Refractory Cerebellar Brain TumorsRecruitingNCT03911388Phase 11 country
- Selective Activation of the Adrenomedullin Receptors in MigraineRecruitingNCT07451769Not applicable1 country
- rTMS as an Intervention for Levodopa-induced DyskinesiaRecruitingNCT06570824Not applicable1 country
- Quality of Life in Women With X-linked AdrenoleukodystrophyRecruitingNCT046757491 country
- Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-NetherlandsRecruitingNCT06193252Not applicable1 country
- Efficacy of RGn600 in Patients With Mild-to-moderate Alzheimer's DiseaseRecruitingNCT05926011Not applicable1 country
- PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute StrokeRecruitingNCT061213361 country
- Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)RecruitingNCT06482268Phase 11 country
- Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI TrialNot yet recruitingNCT07742553Phase 2/31 country
- ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's DiseaseNot yet recruitingNCT07718659Phase 11 country
- HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled TrialRecruitingNCT06719947Phase 2/32 countries
- Safety, Tolerability, and Preliminary Effectiveness of CTH120 in Fragile X SyndromeRecruitingNCT07654114Phase 21 country
- Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease - EUNot yet recruitingNCT07708675Not applicable
- A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)RecruitingNCT05462106Phase 1/23 countries
- Tislelizumab in Combination With Bevacizumab and Capecitabine in Advanced Solid Tumors With Evaluation in Immunotherapy-Resistant and Central Nervous System DiseaseNot yet recruitingNCT07681297Phase 1/21 country
- Predisposing Factors for Post-stroke EpilepsyRecruitingNCT058645471 country
- Auricular VNS Following Intracerebral HemorrhageRecruitingNCT06799390Not applicable1 country
- Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic StrokeEnrolling by invitationNCT07681102Not applicable1 country
- Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord InjuryNot yet recruitingNCT07674511Not applicable1 country
- Combined Analysis of Inflammatory Biomarkers for CNS Autoimmune Diseases DiagnosticRecruitingNCT050567401 country
- Tolerance Study of Robotic-Assisted Virtual Reality Walking Rehabilitation for Non-Walking Stroke PatientsRecruitingNCT06053619Not applicable1 country
- F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project)Enrolling by invitationNCT024141781 country
- F 18 T807 Tau PET Imaging of Alzheimer's DiseaseRecruitingNCT024143471 country