Cachexia clinical trials
The registry lists 331 studies for Cachexia across more than 10 countries. 75 are recruiting or about to start. 144 of them are mainly about Cachexia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
International Food Policy Research Institute (7) · Pfizer (6) · University of Erlangen-Nürnberg Medical School (6) · Helsinn Therapeutics (U.S.), Inc (6) · National Taiwan University Hospital (6) · Norwegian University of Science and Technology (5) · M.D. Anderson Cancer Center (5) · Aga Khan University (5)
What is being tested here
Drugs under test in Cachexia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma · Phase 3 · Changchun GeneScience Pharmaceutical Co., Ltd.
- Nov 2026A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of SXRN Injection in Patients With Cancer Cachexia · Jiangsu Nutai Biologics Co., Ltd
- Nov 2026Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh · World Vision US
- Dec 2026Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau · Trustees of Dartmouth College
- Dec 2026A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer · Second Xiangya Hospital of Central South University
- Dec 2026Postbiotics Ameliorate Cachexia in Patients With Non-small-cell Lung Cancer · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Dec 2026Mechanism of Sarcopenia in Heart Failure · Aarhus University Hospital
- Dec 2026The Effect of Locally Made Nutritional Supplementation on Cancer Cachexia in Bangladesh: A Quasi-experimental Study. · International Centre for Diarrhoeal Disease Research, Bangladesh
- Dec 2026A Prospective Real-World Observational Study of Nanocrystalline Megestrol Acetate in Patients With Cancer Cachexia · Changchun GeneScience Pharmaceutical Co., Ltd.
- Jan 2027Choline to Improve Malnutrition and Enhance Cognition · Washington University School of Medicine
Who these studies take
Of the 56 Cachexia studies recruiting now, 32 (57%) set no upper age limit and 15 (27%) stop at 75 or younger. 8 (14%) take children under 18. 3 (5%) are for women only and 0 (0%) for men only; 17 (30%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 44 (79%) | 41 (73%) |
| 30 | 46 (82%) | 43 (77%) |
| 40 | 47 (84%) | 44 (79%) |
| 50 | 46 (82%) | 45 (80%) |
| 65 | 44 (79%) | 43 (77%) |
| 75 | 44 (79%) | 43 (77%) |
| 85 | 38 (68%) | 37 (66%) |
Across all 331 studies, recruiting or not: 31% stop at 75 or younger and 23% at 65; 22% take children; 5% are for women only and 2% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cachexia studies take
Of 21 phase 1 interventional studies under Cachexia, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 11 mo8–25 · 21 studies | — | — |
| Interventional, no phase | 19 mo12–49 · 77 studies | — | 19 mo11–49 · 75 studies |
| Observational | 38 mo19–48 · 38 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered3
- Phase 1/2 Study of DS010 in Advanced Cancer Patients With CachexiaNov 6, 2026NCT07921576
- Master Protocol for the Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLCOct 22, 2026NCT07888075
- A Phase II Clinical Study Evaluating the Efficacy and Safety of SXRN Injection in Patients With Cancer CachexiaOct 22, 2026NCT07890324
Studies
Recruiting first, then most recently updated. Showing 50 of 331. Browse all 331 → or search them.
- Phase 1/2 Study of DS010 in Advanced Cancer Patients With CachexiaRecruitingNCT07921576Phase 1/21 country
- Hospital-Based Prospective Cohort of Malnutrition Under 6-Month Study (HOSPIC-6-Study)RecruitingNCT078313431 country
- Visugromab in Cachexia International TrialRecruitingNCT07112196Phase 2/314 countries
- Master Protocol for the Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLCNot yet recruitingNCT07888075Phase 2/3
- A Phase II Clinical Study Evaluating the Efficacy and Safety of SXRN Injection in Patients With Cancer CachexiaNot yet recruitingNCT07890324Phase 21 country
- Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, BangladeshEnrolling by invitationNCT07591064Not applicable1 country
- A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and FatigueRecruitingNCT06989437Phase 2/321 countries
- A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight LossNot yet recruitingNCT07663630Phase 12 countries
- The First in Human Study of QLS2319 in Healthy Subjects and Cancer CachexiaRecruitingNCT07735104Phase 1/21 country
- Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in EthiopiaRecruitingNCT06380504Not applicable1 country
- Efficacy and Safety of MitoQ in Improving Cancer CachexiaNot yet recruitingNCT07836777Phase 2
- Using Strength Tests to Better Understand How Pancreatic Cancer Affects Muscle Mass and Quality of LifeRecruitingNCT07255001Not applicable1 country
- Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young ChildrenRecruitingNCT07451951Not applicable1 country
- A Multimodal Integrated Intervention for Kidney CachexiaRecruitingNCT07107087Not applicable1 country
- A Trial Testing a Two-way SMS Platform to Recognize and Prevent Wasting Among HIV-infected and HIV-exposed Uninfected Children in KenyaRecruitingNCT06842732Not applicable1 country
- Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc AdenocarcinomaRecruitingNCT053765921 country
- Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung CancerRecruitingNCT05705492Phase 21 country
- Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in KenyaRecruitingNCT06441305Not applicable1 country
- Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing ChemotherapyRecruitingNCT06937177Phase 22 countries
- Routine Evaluation of People Living With CancerRecruitingNCT044066621 country
- Spatial Multi-omics and Intelligent Early Warning of Pancreatic Cancer CachexiaRecruitingNCT076702861 country
- Phase 2 Cachexia Clinical Trial to Evaluate the Efficacy and Safety of ASCA101RecruitingNCT07168226Phase 21 country
- A Phase I Clinical Study to Evaluate the Efficacy and Safety of GB18 Injection in Patients With Tumor CachexiaRecruitingNCT07519564Phase 11 country
- A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of SXRN Plasmid DNA Technique in Patients With Advanced Solid TumorsRecruitingNCT06736275Early Phase 11 country
- An Phase I/IIa Clinical Study to Evaluate the Safety/Tolerability, Pharmacokinetics and Preliminary Efficacy of INB301 Injection in Patients With Cancer CachexiaNot yet recruitingNCT07584057Phase 1/21 country
- Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)RecruitingNCT070835571 country
- Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and ImmunotherapyNot yet recruitingNCT07565415Phase 21 country
- A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical CancerRecruitingNCT07338487Phase 11 country
- Intestinal Microbiota Transplantation for Treating Advanced Tumor CachexiaNot yet recruitingNCT07533227Phase 2
- Study of the Safety and Efficacy of DS010 in Patients With Cancer CachexiaNot yet recruitingNCT07530666Phase 1/21 country
- Study on the Pathogenesis and Reversal Strategies of Cancer Cachexia Based on Multi-OmicsRecruitingNCT07519837Not applicable1 country
- Metabolism Evaluation Through Resting Indirect Calorimetry in Bladder Cancer (METRICS)RecruitingNCT067212601 country
- Building Opportunities for Nurturing Care to Enhance Child Development in Eastern and Southern AfricaNot yet recruitingNCT07430826Not applicable
- Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in KenyaNot yet recruitingNCT07420062Not applicable1 country
- Sarcopenia and Cachexia in Patients With Lung CancerEnrolling by invitationNCT067306851 country
- Efficacy of Mobile Health Application in Promotion of Exclusive Breast Feeding and Young Child Feeding Practices in PakistanRecruitingNCT05590351Not applicable1 country
- Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular CarcinomaNot yet recruitingNCT07356037Phase 31 country
- Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant DiseasesRecruitingNCT04067167Not applicable1 country
- Feasibility Study for Repurposing RET InhibitorsNot yet recruitingNCT07146893Early Phase 11 country
- Impact of Diet and Nutrition on Growth and Development in Young ChildrenRecruitingNCT060186361 country
- A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of SXRN Injection in Patients With Cancer CachexiaRecruitingNCT07231120Phase 11 country
- REVOLUTION Surgery (REVOLUTION Surgery)RecruitingNCT056428191 country
- A Prospective Real-World Observational Study of Nanocrystalline Megestrol Acetate in Patients With Cancer CachexiaRecruitingNCT07243379Phase 41 country
- To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GB18 Injection in Healthy ParticipantsRecruitingNCT07237464Phase 11 country
- Postbiotics Ameliorate Cachexia in Patients With Non-small-cell Lung CancerNot yet recruitingNCT07185308Not applicable1 country
- Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea SequelaeRecruitingNCT05519254Phase 31 country
- Structural Characteristics of Trunk and Limb Muscles in Cachectic Colorectal Cancer PatientsRecruitingNCT067804231 country
- Influence of Protein Intake on Muscle Mass and Health-related Quality of Life During and After RadiotherapyRecruitingNCT064802661 country
- Body Composition and Psychosocial Factors in ICI-Treated Cancer PatientsRecruitingNCT071309811 country
- Patient Recorded Indexing MeasurementsRecruitingNCT058992051 country