An observational study in Obesity and Obesity-related Medical Conditions, Diabetes and Atherosclerotic Disease, sponsored by Bettina Mittendorfer. Recruiting at 1 site in United States. Open to participants aged 18 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by Bettina Mittendorfer · Observational
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a substance is handled in the body) at the University of Missouri. As technology changes and uses new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure the results are accurate. Reproducibility means performing the same test more than once to see if the same results can be achieved each time. This study will look at the validation and reproducibility of tests and laboratory assays in participants who are healthy or affected by relevant endocrine, cardiometabolic, and musculoskeletal disorders.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 100 is below the median of 114 across 2,154 observational studies indexed under Obesity.
Browse Obesity studies →Bettina Mittendorfer is the lead sponsor of 4 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
convenience population of volunteers in mid-Missouri region
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants may opt to have testing performed including blood sampling, urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance test, consuming a test meal, having imaging performed such as MRI, DEXA, MRS, having adipose (fat) or muscle biopsies, or non-invasive endothelial function testing to investigate use of different assays, different sample treatment approaches to determine optimal conditions that produce the most accurate and reproducible results, and/or repeat testing on different days or with different equipment that measures the same variable.
Evaluation of the validity and reproducibility of insulin results in the laboratory environment
Comparison of insulin results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for endothelial cell collection
endothelial cell quantity collected
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for mixed meal ingestion
palatability of meal type (protein concentration, carbohydrate concentration) as measured by amount of meal consumed
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urinalysis results in the laboratory environment
Comparison of urinalysis results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for glucose tolerance testing
glucose levels (mg/dL) at various time points including fasting, random, and postprandial
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for DEXA
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for MRI
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for MRS
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility of vascular (endothelial) function test
non-invasive vascular function test (measured using EndoPat machine)
Time frame: through study completion, up to 6 months
Validation and reproducibility of adipose (fat) tissue biopsy
microscopic characteristics of tissue collected
Time frame: through study completion, up to 6 months
Validation and reproducibility testing of muscle tissue biopsies
microscopic characteristics of tissue collected
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of C-peptide results in the laboratory environment
Comparison of C-peptide results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of glucagon results in the laboratory environment
Comparison of glucagon results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of free fatty acid level results in the laboratory environment
Comparison of free fatty acid level results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of glucose results in the laboratory environment
Comparison of glucose results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of ketone body results in the laboratory environment
Comparison of ketone body results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of cytokine results in the laboratory environment
Comparison of cytokine results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of adipokine results in the laboratory environment
Comparison of adipokine results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of lipid profile results in the laboratory environment
Comparison of lipid profile results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine calcium results in the laboratory environment
Comparison of urine calcium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine magnesium results in the laboratory environment
Comparison of urine magnesium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine phosphorous results in the laboratory environment
Comparison of urine phosphorous results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine sodium results in the laboratory environment
Comparison of urine sodium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine oxalate results in the laboratory environment
Comparison of urine oxalate results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine citrate results in the laboratory environment
Comparison of urine citrate results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Plan to share: No
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Bettina Mittendorfer