Sleep Bruxism clinical trials
The registry lists 62 studies for Sleep Bruxism across more than 10 countries. 11 are recruiting or about to start. 56 of them are mainly about Sleep Bruxism (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-16.
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Breast cancer · Recruiting: 2 came in, 3 changed
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· Enrollment: 300 → 450 participants
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Who runs them
Federal University of Pelotas (6) · University of Nove de Julho (4) · Wroclaw Medical University (4) · CES University (2) · Escoles Universitaries Gimbernat (2) · Universidade Federal do Rio de Janeiro (2) · University of Monastir (2) · Hasan Kalyoncu University (2)
What is being tested here
Drugs under test in Sleep Bruxism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Botulinum toxin type A | 0 | 0 | 5 |
| Prabotulinumtoxin A | 0 | 0 | 1 |
| Gabapentin | 0 | 0 | 1 |
| Trazodone | 0 | 0 | 1 |
| Melissa officinalis | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Nov 2026Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur Orchestras · University Medical Center Goettingen
- Dec 2026Relationship Between Selected Parameters and Bruxism · Wroclaw Medical University
- Dec 2026Selected Disorders and Sleep Bruxism · Wroclaw Medical University
- Dec 2026Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism · Necmettin Erbakan University
- Oct 2027Manual Therapy in Vagus Nerve Neuromodulation for the Treatment of Bruxism · Escoles Universitaries Gimbernat
- Oct 2027Surface Electromyography in the Detection and Assessment of Bruxism · Escoles Universitaries Gimbernat
Who these studies take
Of the 5 Sleep Bruxism studies recruiting now, 2 (40%) set no upper age limit and 3 (60%) stop at 75 or younger. 2 (40%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (80%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (40%) | 2 (40%) |
| 18 | 3 (60%) | 3 (60%) |
| 30 | 2 (40%) | 2 (40%) |
| 40 | 2 (40%) | 2 (40%) |
| 50 | 2 (40%) | 2 (40%) |
| 65 | 2 (40%) | 2 (40%) |
| 75 | 2 (40%) | 2 (40%) |
| 85 | 2 (40%) | 2 (40%) |
Across all 62 studies, recruiting or not: 79% stop at 75 or younger and 69% at 65; 27% take children; 5% are for women only and 2% for men only; 56% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sleep Bruxism studies take
Of 19 interventional studies with no phase under Sleep Bruxism, half reached primary completion within 6 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 6 mo4–13 · 19 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 62. Browse all 62 → or search them.
- Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur OrchestrasRecruitingNCT077148371 country
- Bruxism Induced by Obstructive Sleep Apnoea.Not yet recruitingNCT075119461 country
- Relationship Between Selected Parameters and BruxismEnrolling by invitationNCT042145611 country
- Bruxism Therapy of Facial PainRecruitingNCT07611643Not applicable1 country
- Effect of Night Guard Use on Masseter Muscle Thickness in Children With BruxismRecruitingNCT07548502Not applicable1 country
- Selected Disorders and Sleep BruxismEnrolling by invitationNCT030834051 country
- 3D-Printed vs Conventional Acrylic Stabilization Splints in Young Adults With Bruxism and Temporomandibular Disorders: A Randomized TrialRecruitingNCT07433725Not applicable1 country
- Manual Therapy in Vagus Nerve Neuromodulation for the Treatment of BruxismNot yet recruitingNCT07074964Not applicable1 country
- Surface Electromyography in the Detection and Assessment of BruxismNot yet recruitingNCT070709471 country
- mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in BruxismNot yet recruitingNCT06457646
- Effectiveness of Melissa Officinalis for the Treatment of Probable Sleep Bruxism in Children and AdolescentsRecruitingNCT06214637Phase 11 country
- Low-Level Laser Therapy Versus Occlusal Splint Therapy for Bruxism in ChildrenCompletedNCT07865845Not applicable1 country
- Synchronous vs Asynchronous Telerehabilitation for BruxismCompletedNCT07827495Not applicable1 country
- Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of BruxismActive, not recruitingNCT07665398Not applicable1 country
- Comparison of Dry Needling and Two Botulinum Toxins for BruxismCompletedNCT07452510Not applicable1 country
- Smartwatch Analysis of Sleep BruxismCompletedNCT074531211 country
- A Sensor-enhanced Mouth Guard to Quantitatively Measure Bite Compression Forces.TerminatedNCT066884741 country
- Efficacy of AesyBite Active in Reducing Sleep Bruxism ActivityCompletedNCT06153810Not applicable1 country
- Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility StudyCompletedNCT03363204Not applicable1 country
- Repeated Botulinum Toxin Type A Injections on Intramuscular Fat Accumulation in Individuals With Sleep Bruxism.CompletedNCT07266064Not applicable1 country
- Changes in Bruxism Activity After Periodontal Treatment in Patients With PeriodontitisCompletedNCT07053878Not applicable1 country
- Diaphragmatic Breathing for Sleep Bruxism in Adults: A Randomized Controlled TrialCompletedNCT07181642Not applicable1 country
- Efficacy of Botulinum Toxin and Marjoram Oil Applications in BruxismCompletedNCT06674733Not applicable1 country
- Electromyographic Assessment of Sleep Bruxism in Patients With Stage III and IV PeriodontitisCompletedNCT070538651 country
- Changes in Electromyographic Activity in Aligner Treatment of Adult Patients With and Without Nocturnal BruxismSuspendedNCT06343194Not applicable1 country
- Pain and Mobility in Children With Sleep BruxismCompletedNCT069373331 country
- Ultrasonographic Evaluation of the Effect of Occlusal Splint Treatment on Masseter Muscle Thickness in Children With Sleep Bruxism:A Clinical Pilot StudyCompletedNCT068943421 country
- Impact of Bruxism Related Arousals on Cardiovascular Risk in Co-morbid Insomnia and Sleep ApneaCompletedNCT049370361 country
- Effects of Different Occlusal SplintsCompletedNCT06893744Not applicable
- Effects of Photobiomodulation in Children With Down Syndrome and Possible Sleep BruxismCompletedNCT04211870Phase 1/21 country
- The Effect of Stress, Anxiety, and Depression Experienced by Pregnant Women on Sleep Bruxism and Oral HealthCompletedNCT06520241Not applicable1 country
- Investigation of Adolescents With Nocturnal BruxismCompletedNCT062597861 country
- Occlusal Stabilization Splints and Sleep Disordered BreathingWithdrawnNCT04078074Not applicable
- All-ceramic Crowns in Patients With Sleep BruxismCompletedNCT03039985Not applicable1 country
- Prevalance of Sleep Bruxism Among a Group of Egyptian ChildrenStatus unknownNCT05784454
- The Use of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle to Treat Sleep BruxismCompletedNCT05620316Not applicable1 country
- Evaluation of Intravascular Irradiation of Blood in Children With Sleep BruxismStatus unknownNCT05301452Phase 2
- Occlusal Splints in the Treatment of Sleep BruxismCompletedNCT04934449Not applicable1 country
- The Effect of Sleep Hygiene and Exercise Therapy in Children With Sleep BruxismCompletedNCT05323942Not applicable1 country
- Effect of the Intervention "Food, Fun and Family" on Sleep Bruxism in ChildrenStatus unknownNCT05310162Not applicable
- OstiSense Biosensor in Bruxism Reduction - A Clinical StudyWithdrawnNCT03749928Not applicable1 country
- Aspects Associated With Obstructive Sleep Apnea, Bruxism and Orofacial PainCompletedNCT037664641 country
- Aspects Associated With Sleep QualityCompletedNCT037664771 country
- Association Between Obstructive Sleep Apnea and BruxismCompletedNCT038102481 country
- Factors Affecting Patients With Myofascial Temporomandibular DisordersCompletedNCT048421361 country
- Validation of a Diagnostic Method for Quantification of Sleep BruxismCompletedNCT03325920Not applicable1 country
- Bruxism Xeomin® Intervention TrialStatus unknownNCT04792398Phase 41 country
- Treatment Sleep Bruxism With the Luco Hybrid OSA ApplianceCompletedNCT02882880Not applicable1 country
- Sleep Hygiene Measures for Sleep Bruxism in ChildrenStatus unknownNCT04501237Not applicable1 country
- Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD PatientTerminatedNCT03522207Phase 41 country