An observational study in Bruxism, sponsored by University of Monastir. Not yet recruiting. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-06-13.
Sponsored by University of Monastir · Observational
The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are:
Participants will:
Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms.
Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.
151 studies on the registry are indexed under Bruxism; 39 are open to participants now.
This study's planned enrollment of 169 is above the median of 89 across 55 observational studies indexed under Bruxism.
Browse Bruxism studies →University of Monastir is the lead sponsor of 114 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
A total of 170 participants will be included in this study.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
The biological significance of HTR2A and DRD3 in bruxism remains unclear as molecular analyses, including genetic association studies, have not explored the mRNA expression of genes implicated in bruxism. This study aims to evaluate the influence of genetic polymorphisms affecting DRD3 (rs6280) and HTR2A (rs6313) on bruxism to identify potentially associated genotypes. Additionally, it aims to investigate the expression of HTR2A and DRD3 to elucidate their biological significance in bruxism.
PCR-RFLP Analysis
Time frame: 1 year
No study locations are listed for this record.
Plan to share: No
Start is estimated for Jun 2024; primary completion for Dec 2024, 6 months later.
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This study is not yet recruiting, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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