Blepharoptosis clinical trials
The registry lists 75 studies for Blepharoptosis across more than 10 countries. 14 are recruiting or about to start. 62 of them are mainly about Blepharoptosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Sheba Medical Center (5) · University of Miami (4) · RVL Pharmaceuticals, Inc. (4) · Massachusetts Eye and Ear Infirmary (3) · Meir Medical Center (3) · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (2) · University of California, San Francisco (2) · Santen Pharmaceutical Co., Ltd. (2)
What is being tested here
Drugs under test in Blepharoptosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Brimonidine | 2 | 0 | 4 |
| Oxymetazoline | 1 | 1 | 3 |
| RVL-1201 | 0 | 2 | 3 |
| Botulinum toxin type A | 0 | 0 | 2 |
| Bupivacaine | 0 | 1 | 2 |
| Lidocaine | 0 | 0 | 1 |
| Fibrin Tissue Adhesive | 0 | 1 | 1 |
Drug classes tested here Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Anterior Versus Posterior White Line Advancement Technique in the Correction of Aponeurotic Ptosis · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
- Jun 2027Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study · Abdulkadir Küçük
- Aug 2027Upneeq vs. Lumify Ptosis · Duke University
Who these studies take
Of the 11 Blepharoptosis studies recruiting now, 7 (64%) set no upper age limit and 3 (27%) stop at 75 or younger. 3 (27%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (27%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (27%) | 3 (27%) |
| 18 | 10 (91%) | 10 (91%) |
| 30 | 9 (82%) | 9 (82%) |
| 40 | 10 (91%) | 10 (91%) |
| 50 | 10 (91%) | 10 (91%) |
| 65 | 9 (82%) | 9 (82%) |
| 75 | 9 (82%) | 9 (82%) |
| 85 | 8 (73%) | 8 (73%) |
Across all 75 studies, recruiting or not: 21% stop at 75 or younger and 12% at 65; 29% take children; 3% are for women only and 0% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Blepharoptosis studies take
Of 24 interventional studies with no phase under Blepharoptosis, half reached primary completion within 36 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 36 mo13–57 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting1
- Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective StudyOct 22, 2026NCT07821450
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 75. Browse all 75 → or search them.
- Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective StudyRecruitingNCT078214501 country
- The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma PatientsNot yet recruitingNCT04007276Phase 41 country
- Effect of Suture Material on Eyelid Height Stability After Anterior White-Line Advancement for Aponeurotic Ptosis.Not yet recruitingNCT07847749Not applicable1 country
- A Feedback-enabled Magnetic Device for Temporary Management of BlepharoptosisRecruitingNCT03812016Not applicable1 country
- Capturing Key MG-symptoms Using Smartphone Recordings.RecruitingNCT067434901 country
- Upneeq vs. Lumify PtosisNot yet recruitingNCT07390578Phase 4
- A Study in Chinese Patients With Acquired BlepharoptosisRecruitingNCT06683651Phase 31 country
- Spacer Graft StudyRecruitingNCT04140734Not applicable1 country
- A Prospective Cohort Study on Visual Function and Psychological Conditions Before and After Surgery for Congenital PtosisRecruitingNCT075344361 country
- Comparative Study of Ziplyft Treatment vs. Traditional Blepharoplasty for Upper Eyelid RejuvenationRecruitingNCT07250139Not applicable1 country
- Anterior Versus Posterior White Line Advancement Technique in the Correction of Aponeurotic PtosisRecruitingNCT07003308Not applicable1 country
- Natural History of Oculo-Pharyngeal Muscular Dystrophy (OPMD) - Israel National OPMD RegistryRecruitingNCT071462561 country
- Red Light Ptosis Proof-of-ConceptRecruitingNCT06292182Not applicable1 country
- Objective Evaluation of the Effect of Oculoplastic Operations Using the Vectra M 3D Imaging SystemRecruitingNCT06040671Not applicable1 country
- Anterior Approach Levator Plication for Congenital Ptosis, With or Without Scraping of the Levator Muscle SurfaceCompletedNCT07924228Not applicable1 country
- Performance and Safety Assessment of SPRING THREAD® Elastic Tensor Thread in Patients With Mild to Moderate Facial Ptosis.Active, not recruitingNCT057460781 country
- Telemedicine Follow-up for Routine, Low-Risk Oculoplastic SurgeryCompletedNCT04235803Not applicable1 country
- Oxymetazoline Drops for Acquired Blepharoptosis From SynkinesisCompletedNCT05945615Phase 31 country
- Phenylephrine Versus Eyelid Taping for Muller's Muscle-Conjunctival Resection (MMCR) EvaluationCompletedNCT05890027Phase 41 country
- Clinical Trial to Improve the Magnetic Levator ProsthesisCompletedNCT03818204Not applicable1 country
- Clinical Trial Comparing Two Non-Surgical Treatments for Severe BlepharoptosisCompletedNCT04678115Not applicable1 country
- A Pharmacokinetics (PK) Study in Healthy AdultsCompletedNCT06911216Early Phase 11 country
- Brimonidine for Intraoperative HemostasisWithdrawnNCT05480098Phase 41 country
- Effect of Upper Eyelid Surgeries on Corneal CharacteristicsCompletedNCT057502511 country
- LEV102 Topical Gel in Acquired BlepharoptosisCompletedNCT05715346Phase 1/21 country
- Comparing Vision Tests in a Virtual Reality Headset to Existing AnaloguesCompletedNCT047144241 country
- A Comparison of the Effect of Suture Material on Blepharoplasty IncisionCompletedNCT04585217Not applicable1 country
- Blepharoptosis in Indonesia: A 5-Year Multicenter Study on Characteristics and Surgical EvaluationCompletedNCT060474181 country
- A RETROspective Study of Patients With TK2dCompletedNCT037015683 countries
- The Effect of Upneeq (Oxymetazoline Hydrochloride 0.1%) on Eyelid Position, Eye Redness, and Eye AppearanceCompletedNCT04831047Phase 41 country
- Effect of Eyelid Patching After Ptosis SurgeryCompletedNCT05770973Not applicable1 country
- NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII PalsyTerminatedNCT03239418Not applicable1 country
- Bupivacaine Epiphora TrialWithdrawnNCT03266081Phase 21 country
- Subconjunctival Injection of Local Anesthetic in Anterior Blepharoptosis RepairStatus unknownNCT02959697Not applicable1 country
- Fibrin Sealant in Eyelid SurgeryStatus unknownNCT05358977Phase 2/3
- The Effect of Varying Brightness on Palpebral ApertureStatus unknownNCT05210491Not applicable1 country
- Safety and Efficacy Study of RVL-1201 in Acquired BlepharoptosisCompletedNCT01848041Phase 1/21 country
- Study of the Safety and Efficacy of RVL-1201 in the Treatment of Acquired BlepharoptosisCompletedNCT02436759Phase 31 country
- The Effect of Lumify™ Eyedrops on Eyelid PositionCompletedNCT03782701Phase 41 country
- A Newly Modified Technique for Levator Muscle Tucking in Blepharoptosis Surgery: An Egyptian Tertiary Center StudyCompletedNCT04883853Not applicable1 country
- Custom Print Megnetic Levator Prosthesis Pilot ComparisonCompletedNCT04807855Early Phase 11 country
- Treatment of Ptosis to Muscular Dystrophy Oculopharyngeal by Myoblast Autologous GraftTerminatedNCT02878694Phase 2/31 country
- Magnetic Correction of Eye Lid ParalysisCompletedNCT02988856Not applicable1 country
- Study of Safety and Efficacy of RVL-1201 in the Treatment of BlepharoptosisCompletedNCT03565887Phase 31 country
- Study of Safety of RVL-1201 in Treatment of BlepharoptosisCompletedNCT03536949Phase 31 country
- Comparison of Fixation Suture Type in Glaucoma SurgeryCompletedNCT03797846Not applicable1 country
- Evaluation of Intraoperative Lagophthalmos FormulaCompletedNCT04291625Not applicable1 country
- Management of Severe Congenital BlepharoptosisCompletedNCT04214379Not applicable1 country
- The Effect of Eyelid Surgery on Dry Eye - a Prospective StudyCompletedNCT023765561 country
- Bupivacaine Injection of Eye Muscles to Treat StrabismusStatus unknownNCT01616108Phase 2/31 country