An observational study in Oculopharyngeal Muscular Dystrophy (OPMD), sponsored by Sheba Medical Center. Recruiting at 1 site in Israel. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-28.
Sponsored by Sheba Medical Center · Observational
The goal of this open prospective multi-disciplinary observational study of patients with OPMD at various stages of clinical manifestations is to explore the natural history of the disease in the Israeli population.
The the following procedures will be performed by a multidisciplinary team:
Neurological and neurocognitive examination; Clinical assessment of of swallowing and severity of dysphagia; Clinical assessment of eyelid ptosis severity; Clinical assessment of respiratory muscles function; Clinical assessment of oral health
871 studies on the registry are indexed under Deglutition Disorders; 237 are open to participants now.
This study's planned enrollment of 300 is above the median of 84 across 249 observational studies indexed under Deglutition Disorders.
Browse Deglutition Disorders studies →Sheba Medical Center is the lead sponsor of 678 studies on the registry; 63 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Genetically Confirmed Oculopharyngeal Muscular Dystrophy
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Other: Non-interventional observational study
No intervention will be studied
Severity of muscle strength decline over time
10-meter walk test
Time frame: 1 year
Penetration/Aspiration Scale
Penetration/Aspiration Scale (PAS)
Time frame: 1 year
Upper Margin Reflex Distance
Upper Margin Reflex Distance
Time frame: 1 year
Lower Margin Reflex Distance
Lower Margin Reflex Distance
Time frame: 1 year
Maximum Expiratory Pressure
Maximum Expiratory Pressure (MEP)
Time frame: 2 years
Cough Peak Flow
Cough Peak Flow (CPF)
Time frame: 2 years
Oral health
Decayed, Missing, and Filled Teeth (DMFT) index
Time frame: 2 years
Dysphagia severity
Yale Pharyngeal Residue Severity Rating Scale
Time frame: 1 year
Functional Oral Intake Scale
Functional Oral Intake Scale (FOIS)
Time frame: 1 year
Swallowing Disturbance
Swallowing Disturbance Questionnaire (SDQ)
Time frame: 1 year
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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