An interventional study of cognitive behavioral therapy and valuation with instruction in Neurobehavioral Components of Reward and Loss Valuation, sponsored by Virginia Polytechnic Institute and State University. Recruiting at 1 site in United States. Open to participants aged 25 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by Virginia Polytechnic Institute and State University · Not applicable, Interventional, and Basic science
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.
8,577 studies on the registry are indexed under Depression; 1,720 are open to participants now.
This study's planned enrollment of 252 is above the median of 81 across 7,063 interventional studies indexed under Depression.
Browse Depression studies →Virginia Polytechnic Institute and State University is the lead sponsor of 127 studies on the registry; 28 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
cognitive behavioral therapy for depression, anxiety, and/or anhedonia
Behavioral: cognitive behavioral therapy
repeat laboratory sessions of a reward/loss learning computer game with specific instructions
Behavioral: valuation with instruction
repeat laboratory sessions of a reward/loss learning computer game without specific instructions
Behavioral: valuation without instruction
cognitive behavioral therapy
repeat laboratory sessions of computerized learning game
repeat laboratory sessions of computerized learning game
change in proportion correct on the 'N-arm bandit learning task'
change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit
Time frame: study entrance to study exit, an average of 12 weeks
change in depression symptoms (Beck Depression Inventory)
change in depression symptoms from study entrance to study exit
Time frame: study entrance to exit, an average of 12 weeks
change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)
change in anxiety symptoms from study entrance to study exit
Time frame: study entrance to exit, an average of 12 weeks
change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)
change in anhedonia symptoms from study entrance to study exit
Time frame: study entrance to exit, an average of 12 weeks
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2021 (actual). Primary completion is estimated for Jul 2027, 71 months after the start.
Of 3,468 non-industry interventional studies with no phase under Depression, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 41. This study's planned 71 months is above that.
Counting every sponsor, half of 3,566 studies reached it within 21 months; a quarter within 9 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Virginia Polytechnic Institute and State University →