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RecruitingNCT07803185Updated Sep 3, 2026

Evaluation of Anhedonia and Emotional Eating in Individuals Using GLP-1 Receptor Agonists

An observational study in Obesity, Emotional Eating and Anhedonia, sponsored by TC Erciyes University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-03.

Sponsored by TC Erciyes University · Observational

From the registry’s dates

  • Started Jun 2026; still recruiting 5 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
60
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 352 studies in Obesity with a site in Turkey — 72 open to participants now, 90 under way, 16 of them phase 3. Obesity · Turkey.

Planned enrollment
103rd of 160
60 · median 82
Started
2026
with 58 others
Observational
160 of 352
32 open now
Primary completion
2026-12
later than 47 of 89 live
Registered
327th of 352
by date

Among the 352 studies in Obesity with a site in Turkey, this one is the 103rd largest by planned enrollment of the 160 observational ones, is one of 59 that started in 2026, is one of 160 observational ones, reaches primary completion later than 47 of the 89 other live ones, and was the 327th registered.

By phase

352 studies; the count open now beside each. This study's row is marked.

No phase160 · 28 open
Observationalthis study160 · 32 open
Phase 326 · 12 open
Phase 43 · 0 open
Phase 22 · 0 open
Phase 2/31 · 0 open

By the year they started

First in 2005; this study’s year is marked. 59 started in 2026.

Size and results

Median enrollment 64 across the 191 interventional studies, 82 across the 160 observational. Of the 236 that completed or were terminated, 7 (3%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 352 studies in Obesity with a site in Turkey, or all of them as a file.
02

Study summary

This prospective observational study evaluates the longitudinal changes in anhedonia levels and emotional eating behaviors among adult individuals initiating glucagon-like peptide-1 (GLP-1) receptor agonist therapy for weight loss. Participants are assessed at baseline (treatment initiation) and after a 6-month follow-up period using standardized psychometric instruments.

Read the detailed description

Glucagon-like peptide-1 (GLP-1) receptor agonists are widely used in the management of obesity and type 2 diabetes by promoting satiety, delaying gastric emptying, and reducing appetite. Beyond peripheral metabolic regulation, GLP-1 receptors located in central reward circuitry suggest potential modulation of psychobiological processes, including reward processing, emotional eating, and anhedonia. However, longitudinal clinical data investigating the trajectory of anhedonia and emotional eating in patients using GLP-1 receptor agonists remain limited. This prospective, single-center observational cohort study is conducted at the Endocrinology and Metabolism Outpatient Clinic of Erciyes University. A total of 60 adult participants newly initiating GLP-1 receptor agonist therapy for weight management are enrolled.

  1. Data collection is performed in two main phases:Baseline Assessment: Demographic characteristics, baseline anhedonia levels via the Dimensional Anhedonia Rating Scale (DARS), and emotional eating patterns via the Emotional Eating Scale (EES / DYÖ) are collected prior to or at the start of therapy.
  2. 6-Month Follow-up Assessment: Participants are re-evaluated using the DARS and EES instruments. In addition, treatment adherence, current dosage, adverse events, and changes in appetite are documented.
03

Conditions studied

  • Obesity
  • Emotional Eating
  • Anhedonia

Keywords

  • GLP-1 Receptor Agonist
  • Glucagon-Like Peptide-1
  • Appetite Regulation
  • Reward System
  • Weight Loss
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adult patients attending the Erciyes University Faculty of Medicine Endocrinology and Metabolism Outpatient Clinic who are newly prescribed GLP-1 receptor agonists for weight management.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age 18 years or older
  • Newly initiated on GLP-1 receptor agonist treatment for weight reduction
  • Willingness to participate in evaluations at baseline and at the 6-month follow-up
  • Ability to read and understand Turkish and possess the cognitive capacity to answer questionnaire items
  • Voluntary provision of written

Exclusion criteria

Exclusion Criteria:

  • Use of GLP-1 receptor agonists for indications other than weight loss
  • Cognitive, neurological, or severe psychiatric conditions preventing completion of self-report questionnaires
  • Substantial missing, inconsistent, or unverifiable questionnaire data compromising analysis integrity
  • Non-participation or dropout at the 6-month follow-up evaluation
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
60 participants (estimated)
Target follow-up
6 Months
Patient registry
Yes

Groups and cohorts

  • GLP-1 Receptor Agonist Group

    Adult participants who have newly initiated GLP-1 receptor agonist treatment for weight reduction and are evaluated at baseline and at 6 months.

06

What researchers measure

Primary outcomes

  1. Change in Dimensional Anhedonia Rating Scale (DARS) Score

    The DARS is a 17-item self-report questionnaire assessing state anhedonia across four domains (hobbies, food/drink, social activities, and sensory experiences). Each item is scored on a 5-point Likert scale from 0 ("Not at all") to 4 ("Extremely"), yielding a total score between 0 and 68. Lower scores indicate more severe anhedonia.

    Time frame: Baseline and 6 months

Secondary outcomes

  1. Change in Emotional Eating Scale (EES) Score

    The Turkish version of the Emotional Eating Scale (DYÖ) consists of 10 items assessing emotional eating across 3 subscales (inability to resist eating desire, food types, and feelings of guilt). Scored on a 4-point Likert scale from 0 ("Never") to 3 ("Always"), total scores range from 0 to 30. Higher scores reflect higher levels of emotional eating behavior.

    Time frame: Baseline and 6 months

07

Study locations

1 of 1 sites recruiting
  • Erciyes University Medical Faculty Hospitals, Department of Endocrinology and Metabolism
    Kayseri, Melikgazi 38000, Turkey (Türkiye)
    Recruiting
08

References and documents

Publications

  • Yapici-Eser H, Appadurai V, Eren CY, Yazici D, Chen CY, Ongur D, Pizzagalli DA, Werge T, Hall MH. Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis. Acta Neuropsychiatr. 2020 Aug;32(4):218-225. doi: 10.1017/neu.2020.14. Epub 2020 Mar 26. PubMed 32213216 ↗
  • Moiz A, Filion KB, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ. Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation. Am J Med. 2025 Jun;138(6):934-940. doi: 10.1016/j.amjmed.2025.01.021. Epub 2025 Jan 31. PubMed 39892489 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jun 2026 (actual). Primary completion is estimated for Dec 2026, 6 months after the start.

Of 791 non-industry observational studies under Obesity, half reached primary completion within 40 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 106. This study's planned 6 months is below that.

Counting every sponsor, half of 836 studies reached it within 39 months; a quarter within 17 and three quarters within 96.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 31, 2026
First posted
Sep 3, 2026
StartActual
Jun 1, 2026
Primary completionEst.
Dec 31, 2026
CompletionEst.
Dec 31, 2026
Last update
Sep 3, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 3, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07803185
Responsible party
Hasan Durmuş (Associate Professor, MD, TC Erciyes University) — Principal investigator
First posted
Sep 3, 2026
Start date
Jun 1, 2026
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
Sep 3, 2026

Study contacts

Hasan Durmuş, MD, Assoc. Prof.
Contact
asandurmus@erciyes.edu.tr
+90 544 370 6917

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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