Altitude Sickness clinical trials

The registry lists 216 studies for Altitude Sickness across more than 10 countries. 46 are recruiting or about to start. 141 of them are mainly about Altitude Sickness (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its narrower condition Pulmonary edema of mountaineers too: 230 studies, 48 open.

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Status

Completed: 127
Not yet recruiting: 26
Status unknown: 26
Recruiting: 17
Active, not recruiting: 11
Terminated: 3

Phase

Phase 4: 30
Phase 1: 13
Phase 2: 11
Phase 3: 9
Early Phase 1: 2

Where

Switzerland: 41
United States: 39
China: 31
Kyrgyzstan: 22
Germany: 10
Nepal: 8

Who runs them

University of Zurich (38) · Silvia Ulrich Somaini (14) · University of Colorado, Denver (9) · Stanford University (5) · United States Army Research Institute of Environmental Medicine (5) · Heidelberg University (4) · Insel Gruppe AG, University Hospital Bern (4) · Mona Lichtblau (3)

What is being tested here

Drugs under test in Altitude Sickness studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Acetazolamide	1	2	25
Human milk oligosaccharides	1	0	1
Fremanezumab	1	0	1
Iron sucrose	0	0	3
Ibuprofen	0	1	3
Methazolamide	0	0	3
Beta-hydroxybutyrate-1,3-butanediol monoester	0	0	2
Prochlorperazine	0	0	2
T89	0	1	2
Erythropoietin	0	0	2

Drug classes tested here Diuretics 1 open · Corticosteroids 1 open · Bronchodilators 1 open · Antiemetics 3 · Phosphodiesterase inhibitors 3

Coming up

1phase 3 study under way

12studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Dec 2026Measurement of Cardiopulmonary Variables After Acute Exposure to High Altitude · Centro Cardiologico Monzino
Dec 2026The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males · University School of Physical Education, Krakow, Poland
Dec 2026Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments · Peking Union Medical College Hospital
Dec 2026Advair HFA in Healthy and HAPE Predisposed Subjects · University of Colorado, Denver
Dec 2026Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory. · Direction Centrale du Service de Santé des Armées
Dec 2026Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain · University of Ottawa
Dec 2026Effects of High Altitude on AMPK Activation · University of Colorado, Denver
Feb 2027Evaluation of Changes in Sleep Efficiency Among PIC DU MIDI Staff Between Nights Spent at Home and Nights Spent in the Workplace Under High Altitude Conditions · University Hospital, Toulouse
May 2027Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica · IU University of Applied Sciences
Jul 2027Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness · Insel Gruppe AG, University Hospital Bern

Who these studies take

Of the 17 Altitude Sickness studies recruiting now, 4 (24%) set no upper age limit and 10 (59%) stop at 75 or younger. 2 (12%) take children under 18. 1 (6%) are for women only and 3 (18%) for men only; 10 (59%) take healthy volunteers.

Recruiting studies that take each age, of 17
Age	Women	Men
10	1 (6%)	1 (6%)
18	13 (76%)	14 (82%)
30	12 (71%)	13 (76%)
40	12 (71%)	12 (71%)
50	10 (59%)	11 (65%)
65	9 (53%)	10 (59%)
75	7 (41%)	7 (41%)
85	4 (24%)	4 (24%)

Across all 216 studies, recruiting or not: 63% stop at 75 or younger and 50% at 65; 9% take children; 3% are for women only and 12% for men only; 75% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Altitude Sickness studies take

Of 18 phase 4 interventional studies under Altitude Sickness, half reached primary completion within 13 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Phase 4	13 mo4–17 · 18 studies	—	—
Interventional, no phase	9 mo3–21 · 76 studies	—	9 mo3–21 · 76 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered2

High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in Children High-altitude Pulmonary EdemaNov 2, 2026NCT07910357
Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High AltitudeOct 28, 2026NCT07901998

Studies

Recruiting first, then most recently updated. Showing 50 of 216. Browse all 216 → or search them.