An interventional study of Descent from 2850m to sea level in High Altitude, Six-minute Walk Test and High Altitude Effects, sponsored by Silvia Ulrich Somaini. Not yet recruiting at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-03.
Sponsored by Silvia Ulrich Somaini · Not applicable, Interventional, and Supportive care
To study the effect of descent from high altitude (Quito Ecuador: 2850m) to sea level on six-minute walking distance and scores in healthy individuals, who live permanently >2600m.
The aim of this research is to investigate the six-minute walking distance and scores before and after descent (high altitude near their living altitude vs. sea level) in healthy individuals, who permanently live at high altitude over 2600m.
216 studies on the registry are indexed under Altitude Sickness; 46 are open to participants now.
This study's planned enrollment of 14 is below the median of 34 across 178 interventional studies indexed under Altitude Sickness.
Browse Altitude Sickness studies →Silvia Ulrich Somaini is the lead sponsor of 17 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Assessment of the six-minute walking distance and scores near their resident altitude at 2850m followed by a descent from 2850m to sea level by bus with a stay for 7 days and again assessment of the same outcomes
Behavioral: Descent from 2850m to sea level
Descent from 2850m to sea level with stay for 7 days
Six-minute walking distance after 7 days at sea level
Difference/change in six-minute walking distance in meter (6MWD) between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
SpO2 (%) at rest and end-exercise after 7 days at sea level
Difference/change in SpO2 (peripheral oxygen saturation) at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Heart rate (beats per minute) at rest and end-exercise after 7 days at sea level
Difference/change in heart rate at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Blood pressure (mmHg) at rest and end-exercise after 7 days at sea level
Difference/change in blood pressure at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Dyspnea and leg discomfort sensation after 7 days at sea level
Difference/change in dyspnea and leg discomfort sensation (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea/leg discomfort) at rest and end-exercise between 2850m and 5-7 days at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
NYHA functional class (1-4) after 7 days at sea level
Difference/change in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise between 2850m and 5-7 days at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Quality of life after 7 days at sea level
Difference/change in quality of life score (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) between 2850m and 5-7 days at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
General well-being after 7 days at sea level
Difference/change in general well-being (Visual Analog Scale 10cm: the higher, the worse) between 2850m and day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to Day 5-7 at sea level
Acclimatization-effect of six-minute walking distance (m) at sea level
Difference/change in six-minute walking distance (6MWD) within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of SpO2 (%) at rest and end-exercise at sea level
Difference/change in SpO2 (peripheral oxygen saturation) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of heart rate (beats per minute) at rest and end-exercise at sea level
Difference/change in heart rate at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of blood pressure (mmHg) at rest and end-exercise at sea level
Difference/change in blood pressure at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of dyspnea and leg discomfort at sea level
Difference/change in dyspnea and leg discomfort (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea/leg discomfort) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of NYHA functional class (1-4) at sea level
Difference/change in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of Quality of Life at sea level
Difference/change in quality of life (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of general well-being at sea level
Difference/change in general well-being (Visual Analog Scale 10cm: the higher, the worse) within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Plan to share: Yes — Data will be provided upon request and based on a clear intention reviewed by an ethical review board.
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Silvia Ulrich Somaini