An interventional study of Curcumin plus Piperine and Placebo in Symptomatic Irreversible Pulpitis (SIP) and Post Operative Pain, Acute, sponsored by Watim Medical & Dental College. Not yet recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Watim Medical & Dental College · Not applicable, Interventional, and Treatment
Among 135 studies in Pain, Postoperative with a site in Pakistan — 39 open to participants now, 42 under way, 5 of them phase 3. Pain, Postoperative · Pakistan.
Among the 135 studies in Pain, Postoperative with a site in Pakistan, this one is the 92nd largest by planned enrollment of the 133 interventional ones that give a count, is the only one that started in 2027, is one of 84 with no phase, reaches primary completion later than 38 of the 41 other live ones, and was the 135th registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
Browse Pain, Postoperative studies →39 of the 135 studies in Pain, Postoperative with a site in Pakistan are open now. Recruiting first, the newest first:
Shaukat Khanum Memorial Cancer Hospital & Research Centre · Sites in Pakistan
Ages 18+
Wah Medical college , POF hospital · Sites in Pakistan
Ages 18–60
King Edward Medical University · Sites in Pakistan
Ages 18–60
Quaid-e-Azam Medical College · Sites in Pakistan
Ages 1–15
Sindh Institute of Urology and Transplantation · Sites in Pakistan
Ages 18–70 · Women only
A study can be open while its sites in Pakistan have not opened yet or have stopped. Only those recruiting at a site in Pakistan →
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years to 60 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
135 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 12 · Phase 2 13 · Phase 3 13 · Phase 4 20
First in 2014; this study’s year is marked. 1 started in 2027.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is below the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Median enrollment 78 across the 133 interventional studies, 60 across the 2 observational. Of the 78 that completed or were terminated, 3 (4%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 135 has an industry lead sponsor. The 10 most frequent:
Watim Medical & Dental College is the lead sponsor of 13 studies on the registry; 10 are open to participants now.
Watim Medical & Dental College has 1 study filed under Pain, Postoperative — fewer than ten, so there is no comparison to draw.
13 of the studies in Pain, Postoperative with a site in Pakistan that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06996561Phase 3Dr. Asma Abdus SalamExploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management | 2027-01-01 |
| NCT07779551Sargodha Medical CollegeComparison of Two Drugs Bupivacaine and Ropivacaine for Postoperative Analgesia in Bilateral Superficial Cervical Plexus Block After Thyroidectomy | 2026-12 |
| NCT07650760Wah Medical college , POF hospitalComparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy | 2026-12 |
| NCT07338006University of Health Sciences LahoreChest Wall Reconstruction Cohort | 2026-12-31 |
| NCT07747584Allied Hospital FaisalabadEffect of Local Anesthetic Infiltration for Postoperative Pain Control in Laparoscopic Abdominal Surgery: A Prospective Randomized Study | 2027-01 |
Add all 13 to your calendar (.ics) → With an account.
Among the 135 studies in Pain, Postoperative with a site in Pakistan, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this study is to evaluate the effectiveness of taking a turmeric extract supplement before a root canal to help reduce tooth pain after the procedure.
Patients diagnosed with symptomatic irreversible pulpitis (severe, irreversible tooth nerve inflammation causing significant pain) in their lower back teeth (mandibular molars) will participate in the study. All participants will receive a standard, single visit root canal treatment. Before the procedure begins, one group of patients will receive an oral supplement containing curcumin (the active compound in turmeric) combined with piperine (black pepper extract, which helps the body absorb curcumin). Another group will receive a placebo (an inactive substance).
The investigators will compare the levels of postoperative pain between the two groups in the days following the root canal treatment to see if the turmeric extract supplement successfully provides better pain relief.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Clinically significant
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Dietary Supplement: Curcumin plus Piperine
Dietary Supplement: Placebo
An oral administration consisting of curcumin paired with piperine, administered preoperatively to enhance bioavailability prior to the root canal treatment.
An inactive capsule manufactured to be completely identical in appearance, color, size, and weight to the active curcumin capsule, administered preoperatively.
Postoperative Pain Score
Postoperative pain will be assessed using a 0-100 mm Visual Analog Scale (VAS), where a score of 0 mm represents "no pain" and a score of 100 mm represents "the worst possible pain." Patients will mark their pain level on a 100 mm line, and higher scores indicate a greater intensity of postoperative pain.
Time frame: 24 Hours
Rescue Analgesic Consumption
The total amount of rescue medication taken by the participants will be recorded. Patients will be instructed to take Ibuprofen as needed for severe postoperative pain. The outcome will be measured as the average number of Ibuprofen tablets consumed per participant during the follow up period. A lower tablet count indicates better pain management by the preoperative intervention.
Time frame: Up to 48 hours post-treatment
Plan to share: No — he individual participant data will not be shared outside the host institution to maintain patient confidentiality and comply with institutional privacy protocols.
Start is estimated for Jan 2027; primary completion for Jun 2027, 5 months later.
Of 2,089 non-industry interventional studies with no phase under Pain, Postoperative, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 23. This study's planned 5 months is below that.
Counting every sponsor, half of 2,102 studies reached it within 11 months; a quarter within 6 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Watim Medical & Dental College