ClinicalTrials.gg
Enrolling by invitationNCT07779551Updated Aug 21, 2026

Comparison of Two Drugs Bupivacaine and Ropivacaine for Postoperative Analgesia in Bilateral Superficial Cervical Plexus Block After Thyroidectomy

An interventional study of Group 1 will receive 10ml of 0.25% bupivacaine and Group 2 will receive 10ml of 0.25% ropivacaine on each side. in Postoperative Pain, sponsored by Sargodha Medical College. Enrolling by invitation at 1 site in Pakistan. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-21.

Sponsored by Sargodha Medical College · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Jan 2026, registered Aug 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
94
Allocation
Randomized
Ages
20 Years to 40 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 134 studies in Pain, Postoperative with a site in Pakistan — 38 open to participants now, 41 under way, 5 of them phase 3. Pain, Postoperative · Pakistan.

Planned enrollment
44th of 132
94 · median 79
Started
2026
with 21 others
No phase
83 of 134
24 open now
Primary completion
2026-12
later than 29 of 40 live
Registered
120th of 134
by date
Lead sponsor
4 of 134
Sargodha Medical College

Among the 134 studies in Pain, Postoperative with a site in Pakistan, this one is the 44th largest by planned enrollment of the 132 interventional ones that give a count, is one of 22 that started in 2026, is one of 83 with no phase, reaches primary completion later than 29 of the 40 other live ones, and was the 120th registered.

Pain, Postoperative

5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.

Browse Pain, Postoperative studies →

Open to participants now

38 of the 134 studies in Pain, Postoperative with a site in Pakistan are open now. Recruiting first, the newest first:

33 more — sign in →

All 38 open studies →

A study can be open while its sites in Pakistan have not opened yet or have stopped. Only those recruiting at a site in Pakistan →

Who these studies take

Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.

This study: 20 Years to 40 Years · all sexes · healthy volunteers too.

The full table on the hub →

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02

Study summary

There is significant difference between bupivacaine and ropivacaine in terms of postoperative pain assessment in patients undergoing total thyroidectomy with bilateral superficial cervical plexus block.

03

Conditions studied

  • Postoperative Pain

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04

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age range:20-40 years.
  2. Both male and female individuals.
  3. Patients classified as (ASA)I-II.
  4. Patients scheduled for elective total thyroidectomy under general anesthesia

Exclusion criteria

Exclusion Criteria:

  1. Patient Refusal
  2. Hypothyroidism,Hyperthyroidism,Retrosternal goiter
  3. Premedication with preoperative analgesics
  4. Excessive alcohol intake,Electrolyte imbalance
  5. Pregnancy or lactation
  6. Coagulation disorders
  7. Additional surgical intervention
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

ASA physical status

The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
94 participants (estimated)

Study arms

  • Other
    Group 1 will receive 10ml of 0.25% bupivacaine on each side,

    Procedure: Group 1 will receive 10ml of 0.25% bupivacaine

  • Other
    Group 2 will receive 10ml of 0.25% ropivacaine on each side

    Procedure: Group 2 will receive 10ml of 0.25% ropivacaine on each side.

Interventions

  • ProcedureGroup 1 will receive 10ml of 0.25% bupivacaine

    After placing the patients in a supine position with the neck slightly extended and rotated away from the side to be blocked,the procedure will be performed under sterile aseptic conditions.The sternocleidomastoid muscle will be identified,and a high-frequency (1O MHz) linear probe will be positioned transversely over the muscle,between the mastoid and clavicle. The cutaneous nerves of the cervical plexus,visible as round hypoechoic structures in the fascial plane beneath the muscle,will be targeted using a 22-gauge short block needle (5 cm) inserted in-plane with the transducer. Negative aspiration will be performed during injection to avoid inadvertent intravascular delivery. An emergency crash cart will remain available throughout the procedure.

  • ProcedureGroup 2 will receive 10ml of 0.25% ropivacaine on each side.

    After placing the patients in a supine position with the neck slightly extended and rotated away from the side to be blocked,the procedure will be performed under sterile aseptic conditions.The sternocleidomastoid muscle will be identified,and a high-frequency (1O MHz) linear probe will be positioned transversely over the muscle,between the mastoid and clavicle. The cutaneous nerves of the cervical plexus,visible as round hypoechoic structures in the fascial plane beneath the muscle,will be targeted using a 22-gauge short block needle (5 cm) inserted in-plane with the transducer. Negative aspiration will be performed during injection to avoid inadvertent intravascular delivery. An emergency crash cart will remain available throughout the procedure

06

What researchers measure

Primary outcomes

  1. Postoperative pain

    Time frame: 24 hours post surgery

  2. time to the first request for analgesia

    Time frame: 24 hours postoperatively

  3. Block-related complications

    Time frame: immediately after the intervention/procedure

07

Study locations

1 site
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 2026 (actual). Primary completion is estimated for Dec 2026, 11 months after the start.

Of 2,089 non-industry interventional studies with no phase under Pain, Postoperative, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 23. This study's planned 11 months is close to that.

Counting every sponsor, half of 2,102 studies reached it within 11 months; a quarter within 6 and three quarters within 23.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 15, 2026
First posted
Aug 21, 2026
StartActual
Jan 22, 2026
Primary completionEst.
Dec 2026
CompletionEst.
Dec 2026
Last update
Aug 21, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07779551
Lead sponsor
Sargodha Medical College
Responsible party
Sponsor
First posted
Aug 21, 2026
Start date
Jan 22, 2026
Primary completion
Dec 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Aug 21, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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