An observational study in Atrial Fibrillation (AF), sponsored by Ankara Ataturk Sanatorium Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 60 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-11-06.
Sponsored by Ankara Ataturk Sanatorium Training and Research Hospital · Observational
Among 55 studies in Atrial Fibrillation with a site in Turkey — 8 open to participants now, 9 under way, 2 of them phase 3. Atrial Fibrillation · Turkey.
Among the 55 studies in Atrial Fibrillation with a site in Turkey, this one is the 16th largest by enrollment of the 25 observational ones, is one of 5 that started in 2025, is one of 25 observational ones, and was the 55th registered.
4,009 studies on the registry are indexed under Atrial Fibrillation; 961 are open to participants now.
This study's enrollment of 240 is below the median of 300 across 1,400 observational studies indexed under Atrial Fibrillation.
Browse Atrial Fibrillation studies →8 of the 55 studies in Atrial Fibrillation with a site in Turkey are open now, in 12 countries. Each count lists the studies.
Of the 612 Atrial Fibrillation studies recruiting now, 407 (67%) set no upper age limit and 44 (7%) stop at 75 or younger; 21 take children under 18; 43 take healthy volunteers.
This study: 60 Years to 90 Years · all sexes · no healthy volunteers.
The full table on the hub →55 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 5 started in 2025.
Median enrollment 1,314 across the 30 interventional studies, 400 across the 25 observational. Of the 40 that completed or were terminated, 15 (38%) have results posted.
20 of 55 have an industry lead sponsor. The 10 most frequent:
Ankara Ataturk Sanatorium Training and Research Hospital is the lead sponsor of 38 studies on the registry; 15 are open to participants now.
Ankara Ataturk Sanatorium Training and Research Hospital has 3 studies filed under Atrial Fibrillation — fewer than ten, so there is no comparison to draw.
4 of the studies in Atrial Fibrillation with a site in Turkey that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05757869Phase 3Janssen Research & Development, LLCA Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation | 2026-12-08 |
| NCT07242326Kotyora Family Medicine Health Management and Education AssociationSNAP AF-52: Dose Appropriateness and Adherence to Oral Anticoagulation in Adults ≥65 With Atrial Fibrillation in Primary Care (Ordu, Türkiye) | 2026-12-30 |
| NCT07877116Hüseyin Ulaş PinarSevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation | 2027-04 |
| NCT07808307Hande CörütTele-Rehabilitation After Catheter Ablation in Patients With Atrial Fibrillation | 2027-06 |
Among the 55 studies in Atrial Fibrillation with a site in Turkey, from their registry updates:
This study examines whether the size of the jugular foramen is associated with atrial fibrillation, a common irregular heart rhythm. The jugular foramen is an opening at the base of the skull through which nerves involved in heart regulation and a major vein pass.
This retrospective study uses existing medical records and head computed tomography (CT) scans from 240 adults aged 60-90 years: 120 with atrial fibrillation and 120 without a history of atrial fibrillation. Researchers measure the jugular foramina on both sides of the skull and compare their estimated volumes between the groups. They also examine whether any association remains after accounting for age, sex, skull size, other medical conditions, and heart ultrasound findings.
No additional scans, treatments, or patient visits are performed for this study. The study assesses an association and cannot establish whether jugular foramen size causes atrial fibrillation.
This single-center, retrospective case-control study evaluates jugular foramen morphology on archived cranial computed tomography (CT) images in relation to atrial fibrillation. The anatomical rationale is that the jugular foramen contains the vagus nerve and major venous structures. Differences in the dimensions of this bony opening may be associated with cardiac autonomic regulation, although the study does not directly measure nerve compression, venous pressure, or vagal function.
Participants are identified from an archive of non-contrast cranial CT examinations performed between January 2022 and July 2026. Cases have documented atrial fibrillation, while controls have no known history of atrial fibrillation and documented sinus rhythm. Selection is stratified by sex and three age bands: 60-69, 70-79, and 80-90 years. Each age-by-sex stratum includes 20 cases and 20 controls.
Two readers, blinded to atrial fibrillation status, independently assess thin-slice CT images using bone-window settings and multiplanar reconstructions. For each jugular foramen, the mediolateral diameter, anteroposterior diameter, and craniocaudal height are measured. Volume is estimated using an elliptical-cylinder model, and the right and left volumes are summed. Bony septation and cranial dimensions are also recorded. Measurements are averaged across readers for analysis. Interobserver and intraobserver agreement are assessed using intraclass correlation coefficients, and volume estimates are compared with semiautomatic segmentation in a subset of 40 participants.
Clinical characteristics and available laboratory measurements are extracted from existing records. Echocardiographic measures include the ratio of early mitral inflow velocity to early diastolic mitral annular velocity (E/e'), systolic pulmonary artery pressure, and left atrial volume index. Echocardiographic and rhythm documentation must be available within 12 months of the CT examination; laboratory measurements are obtained from records within three months of CT.
Analyses compare jugular foramen measurements between cases and controls overall and across age groups. Age-by-sex subgroup comparisons and interaction analyses are exploratory. Multivariable regression evaluates associations while accounting for demographic characteristics, cranial size, clinical factors, and echocardiographic findings. Receiver operating characteristic analyses assess the ability of jugular foramen volume and an age- and sex-adjusted volume score to distinguish cases from controls within the study sample.
All assessments use existing images and medical records. No study-specific imaging, treatment, or follow-up visits are performed. Because this is a retrospective case-control study, findings are interpreted as associations rather than evidence of causation. Any discrimination thresholds derived from this sample require independent validation.
The study population consists of 240 adults aged 60-90 years selected from the cranial CT archive of a single hospital. Eligible CT examinations were performed between January 2022 and July 2026, with echocardiographic and cardiac rhythm documentation available within 12 months of CT. The sample includes 120 participants with documented atrial fibrillation and 120 controls with no history of atrial fibrillation and documented sinus rhythm. Participants were selected consecutively within age- and sex-defined strata, with 20 men and 20 women in each age band (60-69, 70-79, and 80-90 years) per group.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Age 60-90 years.
Non-contrast cranial CT with bone reconstruction at a slice thickness of ≤0.625 mm, performed between January 2022 and July 2026.
Transthoracic echocardiography and cardiac rhythm documentation available within 12 months of the CT examination.
For the atrial fibrillation group: atrial fibrillation documented on a 12-lead or an ambulatory ECG recording lasting at least 30 seconds.
For the control group: no history of atrial fibrillation, sinus rhythm on all available electrocardiograms, and cranial CT performed for indications unrelated to the skull base.
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Exclusion Criteria:
Atrial fibrillation attributable to transient reversible causes.
History of skull-base fracture, skull-base surgery, or skull-base tumor.
Fibrous dysplasia or Paget disease.
Jugular or sigmoid sinus thrombosis.
Intracranial hypertension.
More-than-moderate valvular heart disease.
Cardiomyopathy or congenital heart disease.
Prior cardiac surgery or catheter ablation.
Implanted devices.
CT image artifacts that prevent reliable jugular foramen measurements.
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Atrial Fibrillation Group: 120 adults aged 60-90 years with documented atrial fibrillation.
120 adults aged 60-90 years with no history of atrial fibrillation and documented sinus rhythm.
Total Bilateral Jugular Foramen Volume
Total jugular foramen volume (cm³), calculated as the sum of right and left volumes on archived cranial CT images. Each side is estimated using an elliptical-cylinder model: π/4 × mediolateral diameter × anteroposterior diameter × craniocaudal height, with conversion from mm³ to cm³. Measurements are performed by two readers blinded to group assignment, and their mean is used for analysis. Total volume is compared between participants with atrial fibrillation and controls.
Time frame: Single time point per participant, using the index cranial CT acquired between January 2022 and July 2026; retrospective assessment without follow-up.
Right and Left Jugular Foramen Volumes
Right and left jugular foramen volumes (cm³) are assessed separately on archived cranial CT images using an elliptical-cylinder model. Measurements are averaged across two readers blinded to group assignment and compared between participants with atrial fibrillation and controls.
Time frame: Single time point per participant, using the index cranial CT acquired between January 2022 and July 2026; no longitudinal follow-up.
Discrimination of Atrial Fibrillation by Jugular Foramen Volume
Discrimination between participants with atrial fibrillation and controls is assessed using the area under the receiver operating characteristic curve (ROC AUC), with 95% confidence intervals, for total bilateral jugular foramen volume and its age- and sex-adjusted z-score.
Time frame: Retrospective assessment using the index cranial CT and rhythm documentation within 12 months of CT; no longitudinal follow-up.
Plan to share: No — There is currently no plan to share individual participant data. The study uses retrospective medical records and imaging data, and permission for external data sharing has not been established. Aggregate findings will be reported in scientific publications.
No publications or documents are linked to this record.
Ran from Jan 2025 to primary completion in Sep 2026, 20 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Ankara Ataturk Sanatorium Training and Research Hospital