An observational study in One-lung Ventilation (OLV) and Video-assisted Thoracis Surgery (VATS), sponsored by Ankara Ataturk Sanatorium Training and Research Hospital. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Ankara Ataturk Sanatorium Training and Research Hospital · Observational
One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with postoperative pulmonary complications. Volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) are the conventional modes used during OLV. Flow-controlled ventilation (FCV) is a newer mode that delivers a constant gas flow during both inspiration and expiration through a narrow-bore endotracheal tube, and has been proposed to improve gas distribution and reduce mechanical stress on the lung.
This prospective observational study evaluates oxygenation and respiratory mechanics in adult patients undergoing elective VATS lung resection under OLV. The ventilation mode used for each patient is determined by the attending anaesthesiologist as part of routine clinical care, independently of the study; investigators do not participate in any aspect of patient management and collect data through observation only. Patients are grouped according to the mode used in clinical practice (FCV, VCV, or PCV).
The primary outcome is arterial oxygenation (PaO₂) at 30 minutes of OLV. Secondary outcomes include dynamic lung compliance, driving pressure, mechanical power, and haemodynamic parameters recorded at predefined intervals. A total of 120 patients (ASA I-III, GOLD stage 1-2) are planned for enrolment.
1,233 studies on the registry are indexed under Postoperative Complications; 292 are open to participants now.
This study's planned enrollment of 120 is below the median of 254 across 519 observational studies indexed under Postoperative Complications.
Browse Postoperative Complications studies →Ankara Ataturk Sanatorium Training and Research Hospital is the lead sponsor of 33 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients aged 18 years and older, ASA physical status I-III, scheduled for elective lung resection by video-assisted thoracoscopic surgery (VATS) with planned one-lung ventilation under total intravenous anesthesia at a single tertiary center. Patients are assigned to one of three groups according to the ventilation mode selected by the attending anesthesiologist (FCV, VCV, or PCV); no randomization is performed.
Exclusion Criteria:
Patients ventilated with flow-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist
Patients ventilated with volume-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist
Patients ventilated with pressure-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist
Partial pressure of oxygen (PaO₂) during one-lung ventilation
PaO₂ in mmHg obtained from arterial blood gas analysis of a radial artery sample, measured at 30 minutes after the initiation of one-lung ventilation, with FiO₂ recorded simultaneously
Time frame: 30-minutes after initiation of one-lung ventilation
PaO₂/FiO₂ ratio
Ratio of the partial pressure of arterial oxygen to the inspired oxygen fraction, calculated from arterial blood gas analysis.
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Partial pressure of arterial carbon dioxide (PaCO₂)
PaCO₂ in mmHg obtained from arterial blood gas analysis.
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Dynamic Compliance
Dynamic compliance obtained from ventilator readings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Pleteau Pressure
Pleteau pressure obtained from ventilator readings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Driving Pressure
Driving pressure obtained form ventilator settings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Mechanical Power
Mechanical power (J/min) obtained and calculated form ventilator settings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Peak Inspiratory Pressure
Peak inspiratory pressure obtained form ventilator settings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Mean Airway Pressure
Mean airway pressure obtained and calculated form ventilator readings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Systolic Arterial Pressure
Systolic arterial pressure (mmHg) measured by invasive arterial monitoring
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Diastolic Arterial Pressure
Diastolic arterial pressure (mmHg) measured by invasive arterial monitoring
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Heart Rate
Heart rate (beats per minute) measured by continuous electrocardiographic monitoring
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Mean Arterial Pressure
Mean arterial pressure (mmHg) measured by invasive arterial monitoring
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Peripheral Oxygen Saturation
Peripheral oxygen saturation (SpO₂, %), measured by pulse oximetry
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
pH
pH obtained by arterial blood gas analysis
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
End-tidal CO₂
End-tidal CO₂ (mmHg), measured by capnography
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Tidal Volume
Tidal volume (mL), obtained from ventilator readings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
PEEP
PEEP (cmH₂O), obtained from ventilator readings
Time frame: 0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes
Postoperative pulmonary complications
Composite incidence of respiratory infection, respiratory failure, bronchospasm, atelectasis, pleural effusion, pneumothorax and aspiration pneumonia, assessed during the postoperative hospital stay.
Time frame: From end of surgery through postoperative day 7 or hospital discharge, whichever occurs first
Lenght of stay and readmission
Duration of intensive care stay, ward stay, total hospital stay and hospital readmission after discharge.
Time frame: From date of surgery to date of hospital discharge, up to 30 days
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Ankara Ataturk Sanatorium Training and Research Hospital