An observational study in Extubation Failure, sponsored by Hospital H+ Queretaro. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-30.
Sponsored by Hospital H+ Queretaro · Observational
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team. The model classifies patients by neurological status and uses an effort-based approach, including a "Gray Zone" (40-59 L/min) managed by tidal volume evaluation.
Adult ICU patients receiving invasive mechanical ventilation who successfully complete a spontaneous breathing trial and are considered clinically ready for planned extubation. Participants are recruited consecutively from participating tertiary-care intensive care units.
Exclusion Criteria:
Prior indication for tracheostomy (e.g., severe maxillofacial trauma, upper airway obstruction).
Diagnostic Test: Observational measurement of Cough Peak Flow and Tidal Volume
Patients undergo standardized CPF and pre-cough tidal volume (VT) measurements prior to extubation. Measurements are stratified by cooperation level (Voluntary vs. Reflex).
Extubation failure
Defined as reintubation or the need for rescue Non-Invasive Ventilation (NIV) within 72 hours post-extubation
Time frame: 72 hours following the removal of the endotracheal tube
No study locations are listed for this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Hospital H+ Queretaro