ClinicalTrials.gg
CompletedNCT07761481Updated Aug 12, 2026

CT-Determined Sarcopenia and Mortality in Critically Ill Cancer Patients

An observational study in Sarcopenia, Cancer and Critical Illness, sponsored by Hospital H+ Queretaro. Completed at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-12.

Sponsored by Hospital H+ Queretaro · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
23
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 10 studies in Sarcopenia with a site in Mexico — 3 open to participants now, 4 under way, none of them phase 3. Sarcopenia · Mexico.

Started
2026
with 2 others
Observational
3 of 10
2 open now
Registered
8th of 10
by date
Lead sponsor
1 of 10
Hospital H+ Queretaro

Among the 10 studies in Sarcopenia with a site in Mexico, this one is one of 3 that started in 2026, is one of 3 observational ones, and was the 8th registered.

Sarcopenia

1,329 studies on the registry are indexed under Sarcopenia; 419 are open to participants now.

Browse Sarcopenia studies →

Open to participants now

3 of the 10 studies in Sarcopenia with a site in Mexico are open now. Recruiting first, the newest first:

All 3 open studies →

A study can be open while its sites in Mexico have not opened yet or have stopped. Only those recruiting at a site in Mexico →

Who these studies take

Of the 246 Sarcopenia studies recruiting now, 153 (62%) set no upper age limit and 33 (13%) stop at 75 or younger; 9 take children under 18; 65 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

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02

Study summary

The goal of this observational study is to evaluate the association between computed tomography-determined sarcopenia and muscle quality impairment with 28-day mortality in adult patients (aged 18 and older) with solid or hematologic malignancies admitted to the Intensive Care Unit (ICU).

The main question it aims to answer is: Is lower psoas muscle quality, calculated using the Hounsfield Unit Average Calculation (HUAC), associated with increased 28-day mortality in critically ill cancer patients? Researchers will compare patients who survived at 28 days with those who died to evaluate whether tomographic muscle measurements (HUAC and total psoas area) and clinical nutritional scores (mNUTRIC) differ between groups and predict mortality.

Participants' records will be evaluated through:

  • A retrospective review of electronic medical records to collect demographic, clinical, oncologic, laboratory, and disease severity scores (APACHE II, SOFA, mNUTRIC).
  • Quantitative tomographic assessment of the right and left psoas muscle area and radiation attenuation density (in Hounsfield Units) using existing computed tomography (CT) scans performed during routine clinical care.
  • Follow-up of 28-day vital status (alive or deceased) after ICU admission.
03

Conditions studied

  • Sarcopenia
  • Cancer
  • Critical Illness
  • Malnutrition

Keywords

  • Sarcopenia
  • Critically ill cancer patient
  • Computed tomography
  • Mortality
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Critically ill adult cancer patients (with solid or hematological malignancies) admitted to the Intensive Care Unit (ICU) at Hospital H+ Querétaro between January 2022 and December 2025 who underwent abdominal CT scans during routine clinical management

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patients aged 18 years or older.
  • Confirmed diagnosis of solid or hematological .
  • Admitted to the Intensive Care Unit (ICU) between January 1, 2022, and December 31, 2025.
  • Availability of an abdominal computed tomography (CT) scan performed during routine clinical care at the time of or prior to ICU admission.

Exclusion criteria

Exclusion Criteria:

  • Missing or incomplete clinical, laboratory, or outcome data in the electronic medical record.
  • Non-evaluable abdominal CT scans due to motion artifacts, metal artifacts, or lack of cross-sectional visibility of the bilateral psoas muscles.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
23 participants (actual)
Patient registry
No

Groups and cohorts

  • Survivors

    Critically ill cancer patients admitted to the ICU who survived at 28 days post-admission.

    Other: Computed Tomography Muscle Assessment (HUAC)

  • Non survivors

    Critically ill cancer patients admitted to the ICU who died within 28 days post-admission

    Other: Computed Tomography Muscle Assessment (HUAC)

Interventions

  • OtherComputed Tomography Muscle Assessment (HUAC)

    Quantitative measurement of cross-sectional area and radiological density (Hounsfield Units) of the bilateral psoas muscles on abdominal CT scans obtained during routine care to calculate the Hounsfield Unit Average Calculation (HUAC).

06

What researchers measure

Primary outcomes

  1. 28-Day All-Cause Mortality

    Vital status (alive or deceased) of critically ill cancer patients evaluated at 28 days following their admission to the Intensive Care Unit (ICU). The association with muscle quality metrics, specifically the Hounsfield Unit Average Calculation (HUAC) of the psoas muscles obtained via computed tomography (CT) scan, will be assessed.

    Time frame: At 28 days post-ICU admission

Secondary outcomes

  1. Nutritional Risk Assessment via mNUTRIC Score

    Evaluation of nutritional risk upon ICU admission using the modified Nutrition Risk in Critically Ill (mNUTRIC) score. The score ranges from 0 to 9 points, where 0 represents the lowest nutritional risk and 9 represents the highest nutritional risk (higher scores indicate a worse outcome/higher nutritional risk; a score \> 5 indicates high nutritional risk).

    Time frame: Baseline (at ICU admission)

  2. Total Psoas Muscle Cross-Sectional Area

    Quantitative measurement of the total cross-sectional area of the right and left psoas muscles combined (mm\^2 or cm\^2) derived from abdominal computed tomography (CT) scans to assess muscle mass quantity.

    Time frame: Baseline (CT scans performed within routine care prior to or at ICU admission)

  3. Acute Physiology and Chronic Health Evaluation II (APACHE II) Score

    Assessment of clinical disease severity at ICU admission using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. The score ranges from 0 to 71 points, where 0 indicates no physiological impairment and 71 represents the most severe degree of illness (higher scores indicate greater disease severity and a higher risk of mortality).

    Time frame: At ICU admission (Baseline)

  4. Sequential Organ Failure Assessment (SOFA) Score

    Assessment of organ dysfunction at ICU admission using the Sequential Organ Failure Assessment (SOFA) score. The score ranges from 0 to 24 points, where 0 indicates normal organ function and 24 represents severe multi-organ failure (higher scores indicate greater organ dysfunction and worse prognosis).

    Time frame: Baseline (at ICU admission)

07

Study locations

1 site
  • Hospital H+ Querétaro, Santiago de Querétaro, Querétaro
    Querétaro City, Querétaro 76030, Mexico
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jul 2026 to primary completion in Aug 2026, 0 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 5, 2026
First posted
Aug 12, 2026
StartActual
Jul 10, 2026
Primary completionActual
Aug 5, 2026
CompletionActual
Aug 5, 2026
Last update
Aug 12, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07761481
Lead sponsor
Hospital H+ Queretaro
Responsible party
Jose J Zaragoza, MD MSc (Principal Investigator, Hospital H+ Queretaro) — Principal investigator
First posted
Aug 12, 2026
Start date
Jul 10, 2026
Primary completion
Aug 5, 2026
Completion
Aug 5, 2026
Last update
Aug 12, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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