ClinicalTrials.gg
CompletedNCT07761832Updated Aug 12, 2026

Hemoglobin Trends as a Predictor of Outcomes in Critically Ill Patients (The TRENT-ICU Study)

An observational study in Critical Illness and Anemia, sponsored by Hospital H+ Queretaro. Completed at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-12.

Primary conditionAnemiaRegistry: Critical IllnessReclassifiedWhy we changed it
Registry
Critical Illness — the first condition term the registry derived for this study.
ClinicalTrials.gg
Anemia
Why
  1. Critical Illness is a broad heading, used only when no more specific condition is named.
  2. The study's listed conditions name Anemia.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Hospital H+ Queretaro · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
128
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 37 studies in Anemia with a site in Mexico — 2 open to participants now, 4 under way, 3 of them phase 3. Anemia · Mexico.

Started
2026
with 2 others
Observational
2 of 37
none open now
Registered
37th of 37
by date

Among the 37 studies in Anemia with a site in Mexico, this one is one of 3 that started in 2026, is one of 2 observational ones, and was the 37th registered.

Anemia

1,810 studies on the registry are indexed under Anemia; 215 are open to participants now.

Browse Anemia studies →

Open to participants now

2 of the 37 studies in Anemia with a site in Mexico are open now. Recruiting first, the newest first:

All 2 open studies →

A study can be open while its sites in Mexico have not opened yet or have stopped. Only those recruiting at a site in Mexico →

Who these studies take

Of the 122 Anemia studies recruiting now, 67 (55%) set no upper age limit and 37 (30%) stop at 75 or younger; 34 take children under 18; 23 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 37 studies in Anemia with a site in Mexico, or all of them as a file.
02

Study summary

The goal of this observational study is to evaluate if early absolute hemoglobin decline (during the first 24 hours of admission) can predict prolonged intensive care unit stay (8 days or more) and in-hospital mortality in critically ill adult patients.

The main questions it aims to answer are:

Does absolute hemoglobin decline during the first 24 hours of admission independently predict prolonged intensive care unit stay in critically ill adult patients?

Does absolute hemoglobin decline during the first 24 hours of admission independently predict in-hospital mortality in critically ill adult patients?

Participants will:

Have their routine clinical and laboratory data reviewed retrospectively from their electronic health records (including baseline hemoglobin and a second hemoglobin determination approximately 24 hours after admission). No additional interventions or extra blood draws will be performed beyond routine clinical care.

03

Conditions studied

  • Critical Illness
  • Anemia

Browse trials for

Keywords

  • critical care
  • Hemoglobins
  • Blood Transfusion
  • Prognosis
  • Intensive Care Units
04

In context

Anemia Reclassified

1,810 studies on the registry are indexed under Anemia; 215 are open to participants now.

This study's enrollment of 128 is below the median of 270 across 368 observational studies indexed under Anemia.

Browse Anemia studies →

Lead sponsor

Hospital H+ Queretaro is the lead sponsor of 13 studies on the registry; 6 are open to participants now.

Compared within Anemia, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →

05

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

dult patients admitted to the Intensive Care Unit at Hospital H+ Querétaro, Mexico, between January 2024 and January 2026, who required an ICU stay of more than 48 hours and had serial hemoglobin measurements during routine medical care.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patients (aged 18 years or older) admitted to the Intensive Care Unit (ICU) between January 2024 and January 2026.
  • ICU length of stay greater than 48 hours.
  • At least two determinations obtained with an interval of approximately 24 hours apart during routine medical care.

Exclusion criteria

Exclusion Criteria:

  • Massive bleeding upon ICU admission.
  • Massive transfusion protocol activation.
  • Pregnancy.
  • Hemoglobinopathies.
  • Active hemolytic anemia.
  • Medical records with insufficient information for analysis.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Hemoglobin (Hb)

The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).

06

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
128 participants (actual)
Patient registry
No

Groups and cohorts

  • Critically Ill Adult Patients

    Adult patients admitted to the intensive care unit with an ICU stay of more than 48 hours and at least two hemoglobin determinations obtained approximately 24 hours apart during routine care.

    Other: Early Absolute Hemoglobin Decline

Interventions

  • OtherEarly Absolute Hemoglobin Decline

    Measurement of the absolute difference in hemoglobin concentration (g/dL) between baseline ICU admission and approximately 24 hours post-admission. Data was collected retrospectively from electronic health records.

07

What researchers measure

Primary outcomes

  1. Prolonged Intensive Care Unit Stay

    Incidence of prolonged intensive care unit (ICU) length of stay, defined a priori as an ICU stay equal to or greater than 8 days.

    Time frame: From ICU admission up to 28 days

Secondary outcomes

  1. In-Hospital Mortality

    Incidence of all-cause mortality recorded at hospital discharge.

    Time frame: From ICU admission up to 30 days

08

Study locations

1 site
  • Hospital H+ Querétaro, Santiago de Querétaro, Querétaro
    Querétaro City, Querétaro 76000, Mexico
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jul 2026 to primary completion in Jul 2026, 0 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 3, 2026
First posted
Aug 12, 2026
StartActual
Jul 31, 2026
Primary completionActual
Jul 31, 2026
CompletionActual
Jul 31, 2026
Last update
Aug 12, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07761832
Lead sponsor
Hospital H+ Queretaro
Responsible party
Jose J Zaragoza, MD MSc (Principal Investigator, Hospital H+ Queretaro) — Principal investigator
First posted
Aug 12, 2026
Start date
Jul 31, 2026
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026
Last update
Aug 12, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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