An observational study in Gingivitis and Periodontal Diseases and Periodontitis, sponsored by Abant Izzet Baysal University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-02.
Sponsored by Abant Izzet Baysal University · Observational
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Among 96 studies in Gingivitis with a site in Turkey — 18 open to participants now, 20 under way, none of them phase 3. Gingivitis · Turkey.
Among the 96 studies in Gingivitis with a site in Turkey, this one is the 16th largest by enrollment of the 58 observational ones that give a count, is one of 17 that started in 2025, is one of 58 observational ones, and was the 67th registered.
631 studies on the registry are indexed under Gingivitis; 107 are open to participants now.
Browse Gingivitis studies →18 of the 96 studies in Gingivitis with a site in Turkey are open now. Recruiting first, the newest first:
Biruni University · Sites in Turkey
Ages 18–65 · Healthy volunteers
Recep Tayyip Erdogan University Training and Research Hospital · Sites in Turkey
Ages 18–70 · Healthy volunteers
Nigde Omer Halisdemir University · Sites in Turkey
Ages 8–24 · Healthy volunteers
Ömer Faruk Okumuş · Sites in Turkey
Ages 18–65 · Healthy volunteers
Inonu University · Sites in Turkey
Ages 18–65 · Healthy volunteers
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 53 Gingivitis studies recruiting now, 15 (28%) set no upper age limit and 36 (68%) stop at 75 or younger; 11 take children under 18; 35 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
96 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 17 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 120 is above the median of 93 across 116 observational studies indexed under Gingivitis.
Median enrollment 54 across the 38 interventional studies, 75 across the 58 observational. Of the 71 that completed or were terminated, 0 (0%) have results posted.
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None of the 96 has an industry lead sponsor. The 10 most frequent:
Abant Izzet Baysal University is the lead sponsor of 250 studies on the registry; 59 are open to participants now.
Abant Izzet Baysal University has 8 studies filed under Gingivitis — fewer than ten, so there is no comparison to draw.
6 of the studies in Gingivitis with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07312045Ömer Faruk OkumuşHALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy | 2026-11-25 |
| NCT07592052Inonu UniversityCircadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption | 2027-01-01 |
| NCT07881406Yuzuncu Yil UniversitySalivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis | 2027-04 |
| NCT07882394Biruni UniversityAlpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis | 2027-05-05 |
| NCT07689786Mustafa Kemal UniversityEffects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis | 2027-07-04 |
Add all 6 to your calendar (.ics) → With an account.
Among the 96 studies in Gingivitis with a site in Turkey, from their registry updates:
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This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University Faculty of Dentistry, Department of Periodontology. While the oral microbiome typically maintains a delicate balance, disruptions in this ecosystem are thought to trigger periodontal diseases. Recent evidence suggests that these parasites may contribute to increased inflammation and tissue destruction, potentially playing a role in the etiology of gingivitis and periodontitis.
The study will include 120 participants aged 18 and older who meet the inclusion criteria. Following the collection of demographic data and oral hygiene habits via a questionnaire, a single calibrated examiner will perform comprehensive clinical periodontal examinations. Measurements will include plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and gingival recession (GR) based on the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.
To detect the presence of parasites, unstimulated whole saliva samples and subgingival plaque samples from the deepest periodontal pockets will be collected from each participant. These samples will be analyzed immediately at the Parasitology Laboratory using light microscopy (10X and 40X magnification) to identify live trophozoites. By evaluating the relationship between parasite prevalence and periodontal status, this research aims to contribute to the limited literature on oral protozoa in Turkey and increase clinical awareness regarding their impact on oral health.
The primary objective of this single-center, cross-sectional, prospective study is to evaluate the frequency of Entamoeba gingivalis and Trichomonas tenax in patients with different periodontal health statuses. Despite being the first protozoa identified in the oral cavity, the role of these parasites in the pathogenesis of periodontal destruction remains a critical area of investigation. This study seeks to correlate the presence of these protozoa with clinical periodontal parameters and patient-related factors.
Patient Selection and Recruitment:
A total of 120 patients who apply to the Bolu Abant İzzet Baysal University Faculty of Dentistry, Department of Periodontology, will be screened. Following written informed consent, a detailed questionnaire will be administered to collect data on:
Demographics (Age, sex, education, and economic status)
Medical history (Systemic diseases, smoking, and pregnancy status)
Oral hygiene habits and recent use of antibiotics or antiseptic mouthwashes.
Clinical Periodontal Examination:
Periodontal diagnosis will be performed according to the "2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions." All clinical measurements will be conducted by a single calibrated examiner using a Williams periodontal probe. The following parameters will be recorded:
Plaque index (PI): Evaluated at 4 sites per tooth (0-3 scale).
Gingival index (GI): Assessment of gingival inflammation (0-3 scale).
Bleeding on probing (BOP): Presence/absence of bleeding within 10 seconds of probing, expressed as a percentage.
Probing pocket depth (PPD): Distance from the gingival margin to the base of the pocket (6 sites per tooth).
Clinical attachment loss (CAL): Distance from the cemento-enamel junction to the base of the pocket.
Gingival recession: Distance from the cemento-enamel junction to the gingival margin.
Sample Collection and Laboratory Analysis:
Two types of biological samples will be collected from each participant:
Subgingival plaque: After isolating the area with cotton rolls and removing supragingival plaque, samples will be collected from the 4 deepest periodontal pockets using sterile curettes and transferred into tubes containing 0.9% NaCl.
Unstimulated saliva: Approximately 2 mL of whole saliva will be collected after at least 30 minutes of no food intake or mouth rinsing.
Samples will be transported immediately to the Parasitology Laboratory at Bolu Abant İzzet Baysal University Faculty of Medicine. Three slide preparations per sample will be examined under a light microscope (10X and 40X magnification) to identify the presence of live trophozoites.
The sample size of 120 was determined based on similar prevalence studies in the literature.
Patients aged 18 and older who applied to the Bolu Abant İzzet Baysal University Faculty of Dentistry, Department of Periodontology, and met the inclusion criteria.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Systemically healthy individuals with no clinical signs of gingival inflammation (BOP \< 10%), no clinical attachment loss, and no probing depths \> 3 mm.
Diagnostic Test: Clinical Periodontal Evaluation · Procedure: Microscopic Examination of Oral Protozoa
Patients diagnosed with dental plaque-induced gingivitis characterized by bleeding on probing (BOP ≥ 10%) and no clinical attachment loss or radiographic bone loss, according to the 2017 World Workshop classification.
Diagnostic Test: Clinical Periodontal Evaluation · Procedure: Microscopic Examination of Oral Protozoa
Patients diagnosed with periodontitis (stages I-IV) characterized by interdental clinical attachment loss, probing depths ≥ 4 mm, and radiographic evidence of alveolar bone loss.
Diagnostic Test: Clinical Periodontal Evaluation · Procedure: Microscopic Examination of Oral Protozoa
Comprehensive periodontal examination including plaque index, gingival index, bleeding on probing, probing pocket depth, and clinical attachment loss measurements using a Williams periodontal probe according to the 2017 World Workshop Classification.
Collection of unstimulated saliva and subgingival plaque samples followed by immediate light microscopy examination (10X and 40X magnification) to detect the presence and frequency of Entamoeba gingivalis and Trichomonas tenax trophozoites.
Prevalence of Entamoeba gingivalis and Trichomonas tenax
The presence or absence of live trophozoites of Entamoeba gingivalis and Trichomonas tenax will be determined through light microscopic examination (10X and 40X magnification) of saliva and subgingival plaque samples. The outcome will be reported as the percentage (%) of participants testing positive for each parasite within the different periodontal health groups.
Time frame: Baseline (at the time of clinical examination and sample collection, typically within 1 hour).
Plan to share: No
No publications or documents are linked to this record.
Ran from Dec 2025 to primary completion in Jun 2026, 5 months.
Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 2, 2026: primary completion Jul 2026 → Jun 2026 and completion Sep 2026 → Jun 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Abant Izzet Baysal University →