An interventional study of Non-surgical periodontal treatment and Vitamin D administration in Periodontal Diseases, Gingivitis and Vitamin D Deficiency, sponsored by Recep Tayyip Erdogan University Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-10.
Sponsored by Recep Tayyip Erdogan University Training and Research Hospital · Not applicable, Interventional, and Diagnostic
A review of the literature revealed that while there are studies investigating the relationship between vitamin D and periodontal disease, there are no studies investigating the anti-inflammatory effect of vitamin D on periodontal disease. Investigators hypothesized that the increased incidence of periodontal disease in individuals with vitamin D deficiency might be due not only to pro-inflammatory effects but also to impaired bone metabolism and a decrease in the anti- inflammatory mechanism. Investigators aimed to determine this by comparing serum and DOS levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), 25-hydroxyvitamin D (25(OH)D3), Receptor activator nuclear kappa B ligand (RANKL), osteoprotegerin (OPG), Tumor Necrosis Factor Related Apoptosis induced Ligand (TRAIL), Developmental endothelial locus (Del)-1, Lipoxin, Resolvin, interleukin (IL)-10, and transforming growth factor-β (TGF-β).
The study will include 120 individuals who are systemically healthy based on clinical and radiographic examinations and diagnosed with Stage I-II periodontitis, Stage III-IV periodontitis, chronic gingivitis, and periodontally healthy. Periodontal clinical parameters (Probing pocket depth (PPD), Clinical attachment level (CAL), Bleeding on probing (BOP), Plaque index (PI), Gingival index (GI)) will be recorded three times: before treatment, and 6 and 12 weeks after treatment. Gingival crevicular fluid (GCF) and serum samples will be collected from participants at baseline and 12 weeks later for biochemical analysis.
631 studies on the registry are indexed under Gingivitis; 107 are open to participants now.
This study's planned enrollment of 120 is above the median of 66 across 507 interventional studies indexed under Gingivitis.
Browse Gingivitis studies →Recep Tayyip Erdogan University Training and Research Hospital is the lead sponsor of 88 studies on the registry; 19 are open to participants now.
Compared within Gingivitis, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Periodontal Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Procedure: Non-surgical periodontal treatment · Dietary Supplement: Vitamin D administration · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Non-surgical periodontal treatment · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Non-surgical periodontal treatment · Dietary Supplement: Vitamin D administration · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Non-surgical periodontal treatment · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Non-surgical periodontal treatment · Dietary Supplement: Vitamin D administration · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Non-surgical periodontal treatment · Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Oral Hygiene Education and Patient Motivation
Procedure: Oral Hygiene Education and Patient Motivation
Participants will receive non-surgical periodontal treatment
Participants with vitamin D deficiency will receive supplemental vitamin D as recommended by their doctor
Participants will receive oral hygiene education
Probing pocket depth (PPD)
Time frame: These parameters will be recorded three times: before treatment, and 6 and 12 weeks after treatment
Clinical attachment level (CAL)
Time frame: These parameters will be recorded three times: before treatment, and 6 and 12 weeks after treatment
Collection of gingival crevicular fluid and serum samples
Time frame: These parameters were to be recorded 2 times: before treatment and 12 weeks after treatment
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Recep Tayyip Erdogan University Training and Research Hospital