An interventional study of root canal treatment and intracanal medicament in Necrotic Pulp with Symptomatic Apical Periodontitis, Postoperative Dental Pain and Antimicrobial Effect, sponsored by Future University in Egypt. Not yet recruiting. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-19.
Sponsored by Future University in Egypt · Not applicable, Interventional, and Treatment
The main rational behind intracanal medicament is to kill the bacteria inside the root canal and to avert reinfection. In absence of nutrients, the bacteria remains after obturation in root canal may not survive. Otherwise they may flourish \& If the root canal is not dressed properly with antiseptic medicaments between the visits, the residual bacteria may increase . Thus the use of effective intracanal medication for disinfection of root canal is necessitated . Medicament with long effect and least irritated to periradicular tissue has to be introduced to infiltrate the dentinal tubule eliminating bacteria . As the effect of intracanal medicaments is longer than irrigants, it is generally recommended to fill the root canal between appointments with intracanal medicaments. Calcium hydroxide is the most commonly recommended antimicrobial agent for interappointment medications. It serves as an effective intracanal medicament due to its alkaline pH, which inhibits bacterial growth. However, calcium hydroxide has limitations. .Recently selenium(Se) was introduced as intracanal medication .Se is a mineral essential for the formation of the amino acid selenocysteine, which is directly involved in the maintenance of the immune response. Selenium has been widely used in the medical field in the treatment of cancer, as an activator of bone metabolism, and as a stimulator of the immune system. In this study, it will show that the incorporation of Se, whether as intracanal medication alone or in conjunction with other medications, may potentiate periapical tissue repair after RCS cleaning and shaping procedures.
This study consists of 60 patients divided into 3 group each group having 20 patient.
Intervention 1: intracanal medication using selenium alone .
Intervention 2: intracanal medication using selenium with calcium hydroxide
Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II).
Exclusion Criteria:
Medically compromised patients.
Teeth that have:
Procedure: root canal treatment and intracanal medicament
Procedure: root canal treatment and intracanal medicament
Procedure: root canal treatment and intracanal medicament
Root canal biomechanical preparation followed by intracanal placement of intracanal medicament according to the arm
Post-operative pain
Numerical rate scale (NRS) for measuring post-operative pain after 6 hours upto 96 hours 0-10 scale , with zero meaning ''no pain '' and 10 meaning ''the worst pain imaginable ''
Time frame: 6 hours up to 96 hours
Bacterial Load
Serial dilution technique For measuring bacterial load preplacement of the medication and 2 weeks postplacement .
Time frame: Before intracanal medication injection and 2 weeks following the procedure and before obturating the root canals
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Future University in Egypt