An interventional study of Topical oxygen-releasing oral gel and No intervention in Periodontitis, sponsored by Universiti Sains Malaysia. Not yet recruiting at 1 site in Malaysia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Universiti Sains Malaysia · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if adding an oxygen-releasing gel to a deep dental cleaning treatment can improve gum health more than deep cleaning alone, in adults with severe gum disease. The main questions it aims to answer are:
Researchers will compare one side of each participant's mouth, treated with deep cleaning plus oxygen-releasing gel, to the other side, treated with deep cleaning alone, to see if adding the gel produces a bigger and longer-lasting improvement in gum health.
Participants will:
130 studies on the registry are indexed under Periodontal Pocket; 35 are open to participants now.
This study's planned enrollment of 38 is above the median of 30 across 113 interventional studies indexed under Periodontal Pocket.
Browse Periodontal Pocket studies →Universiti Sains Malaysia is the lead sponsor of 177 studies on the registry; 51 are open to participants now.
Compared within Periodontal Pocket, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Periodontitis. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
This study will involve 2 arms in every patient since it will be a split-mouth study. The first arm (control site) will involve standard treatment (scaling and root debridement) for periodontitis.
Other: No intervention
This study will involve 2 arms in every patient since it will be a split-mouth study. The test arm is the second arm in the same patient but at a different tooth site (test site) which will receive standard treatment plus adjunctive therapy (oxygen-releasing oral gel / blue®m Oral Gel).
Drug: Topical oxygen-releasing oral gel
Scaling and root debridement (RSD), a standard non-surgical periodontal procedure involving mechanical removal of subgingival plaque and calculus using ultrasonic and/or hand instrumentation. RSD will be performed at baseline on all sites (both test and control), and repeated at 6 weeks, 3 months, and 6 months if clinically indicated based on residual probing pocket depth or bleeding on probing. BlueM® oral gel is a topical oxygen-releasing oral gel, containing sodium perborate and lactoferrin as active ingredients. The gel will be applied subgingivally to the test site immediately following scaling and root debridement at baseline, and reapplied once more at the 1-week follow-up visit. No further gel application will occur after week 1.
Scaling and root debridement (RSD), a standard non-surgical periodontal procedure involving mechanical removal of subgingival plaque and calculus using ultrasonic and/or hand instrumentation. RSD will be performed at baseline on all sites (both test and control), and repeated at 6 weeks, 3 months, and 6 months if clinically indicated based on residual probing pocket depth or bleeding on probing. The control arm receive the standard treatment and will not be receiving any placebo gel.
Probing pocket depth (PPD)
The distance measured from the gingival margin to the base of the periodontal pocket. This will be assessed at six sites per tooth (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingual, and disto-lingual) using a standardised UNC-15 periodontal probe exerted with approximately 0.25 N of probing force. It will be recorded in millimetres.
Time frame: Will be measured at: Baseline, at 6-weeks, at 3-months and at 6-months review
Clinical Attachment Level (CAL)
The distance measured from a fixed anatomical reference point, the cementoenamel junction (CEJ), to the base of the periodontal pocket. It is calculated using the formula: CAL = PPD + Gingival Recession (or PPD - Gingival Overgrowth). It will be measured at the same six sites per tooth using a standardised UNC-15 probe. It will also be recorded in millimetres.
Time frame: Will be measured at: Baseline, at 6-weeks, at 3-months and at 6-months review
Bleeding on Probing (BOP)
The presence or absence of provocative capillary bleeding within the sulcus following pocket instrumentation. It will be recorded as a binary outcome ("Yes" if bleeding occurs within 10 seconds of probing, "No" if no bleeding occurs) according to Ainamo \& Bay's Bleeding Index at the evaluated pocket sites (Ainamo \& Bay, 1975).
Time frame: Will be measured at: Baseline, at 6-weeks, at 3-months and at 6-months review
Plaque Score
Time frame: Will be measured at: Baseline, at 6-weeks, at 3-months and at 6-months review
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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