An interventional study of Vit D in Dental Implant, Dental Implant Failed and Vitamin D Deficiency, sponsored by Future University in Egypt. Recruiting at 1 site in Egypt. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-06.
Sponsored by Future University in Egypt · Not applicable, Interventional, and Treatment
Among 154 studies testing Vitamin D in Vitamin D Deficiency — 15 open to participants now, 16 under way, none of them phase 3. Vitamin D · Vitamin D Deficiency.
Among the 154 studies testing Vitamin D in Vitamin D Deficiency, this one is the 139th largest by planned enrollment of the 153 interventional ones that give a count, is one of 5 that started in 2025, is one of 87 with no phase, reaches primary completion later than 13 of the 15 other live ones, and was the 154th registered.
801 studies on the registry are indexed under Vitamin D Deficiency; 60 are open to participants now.
Browse Vitamin D Deficiency studies →15 of the 154 studies testing Vitamin D in Vitamin D Deficiency are open now, in 8 countries. Recruiting first, the newest first:
Yale University · Sites in United States
The Jerzy Kukuczka Academy of Physical Education in Katowice · Sites in Poland
Bangladesh Medical University · Sites in Bangladesh
Bangladesh Medical University · Sites in Bangladesh
Amany Keruakous, MD, MS. · Sites in United States
By country, each count listing its studies:
No approval found in the FDA or EMA files read. How studies give it is on its page →
Of the 37 Vitamin D Deficiency studies recruiting now, 16 (43%) set no upper age limit and 18 (49%) stop at 75 or younger; 10 take children under 18; 11 take healthy volunteers.
This study: 20 Years to 60 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
154 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 18 · Phase 2 16 · Phase 3 8 · Phase 4 27
First in 2001; this study’s year is marked. 5 started in 2025.
This study's planned enrollment of 10 is below the median of 78 across 590 interventional studies indexed under Vitamin D Deficiency.
Median enrollment 75 across the 153 interventional studies. Of the 113 that completed or were terminated, 17 (15%) have results posted.
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2 of 154 have an industry lead sponsor. The 10 most frequent:
Future University in Egypt is the lead sponsor of 104 studies on the registry; 31 are open to participants now.
Future University in Egypt has 2 studies filed under Vitamin D Deficiency — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 154 studies testing Vitamin D in Vitamin D Deficiency, from their registry updates:
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The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.
Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.
Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.
Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.
Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.
Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.
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Exclusion Criteria:
About 5 Participants will receive systemic vitamin D supplementation prior to and/or after dental implant placement. The purpose is to correct vitamin D deficiency and evaluate its effect on implant osseointegration and bone healing.
Drug: Vit D
About 5 Participants will not receive vitamin D supplementation. They will undergo standard dental implant placement and follow-up care without any intervention to correct vitamin D deficiency.
Drug: Vit D
to address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment
Also known as: Dental Implant
Treatment of Dental Implant Osseointegration
Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.
Time frame: 3 Months
marginal bone loss after prosthesis placement
Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.
Time frame: six months after proshtesis placement
Implant Survival Rate
Implant survival rate will be determined by the presence of the implant at the 6-month follow-up without any clinical or radiographic signs of failure, such as mobility, pain, infection, or significant bone loss. This outcome reflects the short-term success of the dental implant.
Time frame: six months after prosthesis placement
Plan to share: No
No publications or documents are linked to this record.
Started Nov 2025 (actual). Primary completion is estimated for Oct 2026, 11 months after the start.
Of 168 non-industry interventional studies with no phase under Vitamin D Deficiency, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 29. This study's planned 11 months is close to that.
Counting every sponsor, half of 170 studies reached it within 11 months; a quarter within 4 and three quarters within 29.
How these figures are worked out, and which studies are left out of them.
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Studies of the drug tested here: Vitamin D