A Phase 2 interventional study of Midodrine and Standard of Care in Sepsis and Low Blood Pressure, sponsored by Mayo Clinic. Recruiting at 5 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-31.
Sponsored by Mayo Clinic · Phase 2, Interventional, and Treatment
This study is being done to determine if early administration of Midodrine can improve outcomes by maintaining a higher mean blood pressure off of intravenous medications. Researchers want to see if Midodrine can help people with sepsis need fewer vasopressors, which could mean shorter hospital stays, less time with uncomfortable tubes, and a smoother recovery overall.
2,416 studies on the registry are indexed under Sepsis; 541 are open to participants now.
This study's planned enrollment of 308 is above the median of 102 across 1,165 interventional studies indexed under Sepsis.
Browse Sepsis studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Patients diagnosed with sepsis within 24 hours of meeting all of the following criteria will be eligible to participate in the study:
Exclusion criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
A score of how well the liver works in people with liver disease such as cirrhosis: class A is mild, B moderate and C severe.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Child-Pugh class
A score of how well the liver works in people with liver disease such as cirrhosis: class A is mild, B moderate and C severe.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Standard of Care
Drug: Midodrine
Subjects will receive standard of care for sepsis and 10 mg of Midodrine every 8 hours administered orally or enterally (via nasogastric tube)
Subjects will receive standard of care for sepsis treatment.
Time alive and without vasopressor support
Measured in hours
Time frame: 28 days
Total vasopressor requirements
Measured as norepinephrine equivalents (µg)
Time frame: 28 days
Central venous access duration
Measured in hours
Time frame: 28 days
Cumulative fluid balance over the first 48 hours
Time frame: 48 hours
Cumulative fluid balance up to 7 days of ICU stay
Time frame: 7 days
ICU Length of Stay
Total number of days admitted to the Intensive Care Unit (ICU)
Time frame: 28 days
Hospital Length of Stay
Total number of days admitted to the hospital
Time frame: 28 days
ICU, hospital, and organ support-free days
Number of ICU, hospital, and organ support-free days
Time frame: 28 days
Plan to share: No
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Studies of the drug tested here: Midodrine