An observational study in Cardiovascular Diseases, Cerebrovascular Disorders and Metabolic Disease, sponsored by Harvard School of Public Health (HSPH). Completed. Open to female participants aged 24 Years to 44 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-14.
Sponsored by Harvard School of Public Health (HSPH) · Observational
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To study, prospectively, the association between dietary patterns and risk of health outcomes (cardiovascular, metabolic, endocrine, neurological, skeletal muscular, cancer) in cohort study of 116,671 women age 24 to 44 years at baseline in 1989 (the Nurses' Health Study II; NHS II).
Health status and lifestyle information was self-reported on a questionnaire at baseline, and on questionnaires distributed to participants biennially thereafter. Dietary intake data was collected in form of a comprehensive, 131-item food frequency questionnaire (FFQ), distributed among participants every four years. The response rate remained over 90%. Dietary data was validated using biomarkers, health status data using medical records.
Dietary pattern scores were derived from FFQs using cumulative average whenever possible from years preceding the outcomes.
Multivariable Cox proportional hazards models were used to evaluate associations between dietary pattern scores and health outcomes, except in case of pregnancy complications (such as gestational diabetes mellitus/GDM and hypertensive disorders of pregnancy/HDPs) where multivariable logistic regression models with generalized estimating equations, with an exchangeable working correlation structure to account for correlated outcomes between pregnancies.
449 studies on the registry are indexed under Cerebrovascular Disorders; 127 are open to participants now.
This study's enrollment of 116,671 is above the median of 450 across 145 observational studies indexed under Cerebrovascular Disorders.
Browse Cerebrovascular Disorders studies →Harvard School of Public Health (HSPH) is the lead sponsor of 154 studies on the registry; 10 are open to participants now.
Compared within Cerebrovascular Disorders, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Cardiovascular Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
The Nurses' Health Study II (NHS II) is a prospective cohort established in 1989 that includes 116,671 female registered U.S. nurses, aged 24-44 at baseline. Mailed questionnaires were administered biennially to collect data on medical and lifestyle factors, with a follow-up rate exceeding 90% for each 2-year cycle. Comprehensive food frequency questionnaires (FFQs) were distributed every four years to collect data on dietary intake.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Dietary intake converted into dietary pattern scores.
Myocardial infarction
Necrosis of heart muscle secondary to prolonged ischemia.
Time frame: 1989-2017
Coronary heart disease
Atherosclerosis
Time frame: 1989-2017
Stroke
Sudden death of brain cells due to lack of oxygen
Time frame: 1989-2017
Diabetes Mellitus (type 2)
Insulin resistance
Time frame: 1989-2017
Gestational Diabetes Mellitus
Glucose intolerance with onset/first recognition during pregnancy
Time frame: 1989-2017
Hypertensive disorders
Chronic hypertension
Time frame: 1989-2017
Hypertensive disorders of pregnancy
Pregnancy induced hypertension, toxemia/preeclampsia
Time frame: 1989-2001
Colon cancer
Malignant tumor in the colon
Time frame: 1989-2017
Breast cancer
Malignant tumor of breast cells
Time frame: 1989-2017
Fractures
Fragility fractures of common sites such as hip and wrist.
Time frame: 1989-2017
Physical functioning
Physical function such as falls, walking, and self care
Time frame: 1989-2017
No study locations are listed for this record.
Plan to share: No — Data are de-identified
Ran from Jan 1989 to primary completion in Apr 2017, 339 months.
Of 75 non-industry observational studies under Cerebrovascular Disorders, half reached primary completion within 103 months of starting (the median), counting those still running; a quarter within 59 and three quarters within 339. This study's 339 months is above that.
Counting every sponsor, half of 79 studies reached it within 103 months; a quarter within 46 and three quarters within 339.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Harvard School of Public Health (HSPH) →