An observational study in Clubfoot, sponsored by University of British Columbia. Completed at 2 sites in 2 countries. Per ClinicalTrials.gov, last updated 2022-05-18.
Sponsored by University of British Columbia · Observational
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Among 10 studies in Clubfoot with a site in United States — 2 open to participants now, 2 under way, none of them phase 3. Clubfoot · United States.
Among the 10 studies in Clubfoot with a site in United States, this one is the only one that started in 2004, is one of 5 observational ones, and was the 1st registered.
69 studies on the registry are indexed under Clubfoot; 15 are open to participants now.
Browse Clubfoot studies →2 of the 10 studies in Clubfoot with a site in United States are open now. Recruiting first, the newest first:
University of Wisconsin, Madison · Sites in United States
Ages 0 wk–12 wk
Texas Scottish Rite Hospital for Children · Sites in United States
Ages up to 18
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 10 Clubfoot studies recruiting now, none (0%) set no upper age limit and 10 (100%) stop at 75 or younger; 9 take children under 18; none take healthy volunteers.
This study: all sexes · no healthy volunteers.
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10 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 1 started in 2004.
This study's enrollment of 370 is above the median of 55 across 27 observational studies indexed under Clubfoot.
Median enrollment 100 across the 5 interventional studies, 370 across the 5 observational. Of the 8 that completed or were terminated, 4 (50%) have results posted.
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None of the 10 has an industry lead sponsor. The 8 most frequent:
University of British Columbia is the lead sponsor of 1,340 studies on the registry; 260 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
University of British Columbia has 6 studies filed under Clubfoot — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 10 studies in Clubfoot with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The goal of this study is to identify and characterize the genetic loci causing idiopathic talipes equinovarus (clubfoot).
The hypothesis is that a few genes account for a substantial fraction of ITEV and that these genes can be identified in defined populations. Towards this goal, in preliminary studies, Dr. Hecht's group has identified two genes, NAT2 and CASP10, which demonstrate evidence for linkage and association to ITEV.
Blood Collection: For this study, the investigators need to obtain blood samples from members of families in which clubfoot has occurred; more specifically, blood samples from the affected child and both parents. DNA will be extracted from blood samples. The DNA will then be tested to look for genetic factors that cause clubfoot.
Study Questionnaires: As well as the blood samples, the investigators have a short questionnaire for the mother of the child with clubfoot to complete.
One family member, usually child, must have clubfoot.
Inclusion Criteria:
The record gives a start of Aug 2004, a primary completion of Dec 2010 and a completion of Aug 2013. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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University of British Columbia →