An interventional study of Exercise with BFR and Exercise in Type 2 Diabetes, sponsored by University of British Columbia. Recruiting at 1 site in Canada. Open to participants aged 19 Years to 64 Years. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by University of British Columbia · Not applicable, Interventional, and Basic science
To conduct a randomized control trial to determine the impact of acute blood flow restriction treadmill walking on immune cell counts, function, and phenotype in adults living with type 2 diabetes.
Participants will be randomized to a regular treadmill walking condition or treadmill walking with blood flow restriction (BFR) condition. In both groups participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve. In the BFR group the cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 minute every 10 minutes based on safety recommendations. The percentage of LOP will 60%. Blood samples will be obtained pre-exercise (PRE), during the final 2 minutes of the final occlusion cycle (OCC), and 3 minutes into the recovery period post-exercise (POST) to measure outcomes.
10,371 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,406 are open to participants now.
This study's planned enrollment of 20 is below the median of 80 across 8,350 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →University of British Columbia is the lead sponsor of 1,339 studies on the registry; 259 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Treadmill walking with blood flow restriction.
Other: Exercise with BFR
Treadmill walking.
Other: Exercise
Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve. The cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 minute every 10 minutes based on safety recommendations. The percentage of LOP will 60%.
Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve.
Change in white blood cell count before, during, and after exercise.
The white blood cell count will be measured using a hematology analyzer before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in monocyte count before, during, and after exercise
The monocyte count will be measured using a hematology analyzer before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in neutrophil count before, during, and after exercise
The neutrophil count will be measured using a hematology analyzer before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in eosinophil count before, during, and after exercise
The eosinophil count will be measured using a hematology analyzer before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in CD66b+ expression before, during, and after exercise
The CD66b+ expression will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in CD11b+ expression before, during, and after exercise
The CD11b+ expression will be measured using flow cytometer before, during, and after exercise
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in CD63+ expression before, during, and after exercise
The CD63+ expression will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in % of classical monocytes before, during, and after exercise
The % of classical monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in % of intermediate monocytes before, during, and after exercise
The % of intermediate monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in % of non-classical monocytes before, during, and after exercise
The % of non-classical monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in TLR-4 expression on classical monocytes before, during, and after exercise
The TLR-4 expression on classical monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in TLR-4 expression on intermediate monocytes before, during, and after exercise
The TLR-4 expression on intermediate monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in TLR-4 expression on non-classical monocytes before, during, and after exercise
The TLR-4 expression on non-classical monocytes will be measured using flow cytometry before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in plasma IL-6 before, during, and after exercise
The plasma IL-6 concentration will be measured using a multiplex assay before, during, and after exercise
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in plasma IL-10 before, during, and after exercise
The plasma IL-10 concentration will be measured using a multiplex assay before, during, and after exercise.
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in plasma TNF-α before, during, and after exercise
The plasma TNF-α concentration will be measured using a multiplex assay before, during, and after exercise
Time frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise
Change in 4-h LPS-induced TNF-α before and after exercise
The LPS-induced TNF-α concentration will be measured from whole-blood culture supernatant using an ELISA before and after exercise.
Time frame: Pre-exercise, immediately post-exercise
Change in 4-h LPS+IL10-induced TNF-α before and after exercise
The LPS+IL10-induced TNF-α concentration will be measured from whole-blood culture supernatant using an ELISA before and after exercise.
Time frame: Pre-exercise, immediately post-exercise
Plan to share: No
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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