National Cancer Institute (NCI): Colonic Neoplasms trials

The registry lists 85 Colonic Neoplasms studies with National Cancer Institute (NCI) as lead sponsor. 4 are open to participants now and 24 have results posted.

Early Phase 1 2Phase 1 38Phase 2 30Phase 3 13No phase 9(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including MesotheliomaRecruitingNCT06885697Phase 1
• Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/2
• Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer StudiesRecruitingNCT00451022
• Collection of Blood From Patients With CancerRecruitingNCT00034216
• Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal CancersCompletedNCT03801915Phase 2Results posted
• Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 PatientsTerminatedNCT03745326Phase 1/2Results posted
• Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal CancerTerminatedNCT03592641Phase 2Results posted
• Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced CancerCompletedNCT03384316Phase 1Results posted
• Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch RepairActive, not recruitingNCT02912559Phase 3Results posted
• Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by SurgeryCompletedNCT01802320Phase 2Results posted
• Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)Active, not recruitingNCT01696981Not applicableResults posted
• Cancer Vaccine Targeting Brachyury Protein in TumorsCompletedNCT01519817Phase 1Results posted
• Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had ChemotherapyTerminatedNCT01339000Phase 2Results posted
• RO4929097 in Treating Patients With Metastatic Colorectal CancerCompletedNCT01116687Phase 2Results posted
• Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal CancerCompletedNCT01105377Phase 2Results posted
• Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by SurgeryTerminatedNCT00835679Early Phase 1Results posted
• Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or AdenomaCompletedNCT00754494Phase 2Results posted
• Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal CancerCompletedNCT00551421Phase 1/2Results posted
• Dasatinib in Treating Patients With Previously Treated Metastatic Colorectal CancerCompletedNCT00504153Phase 2Results posted
• Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line TherapyTerminatedNCT00499369Phase 3Results posted
• VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal CancerCompletedNCT00407654Phase 2Results posted
• AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal CancerTerminatedNCT00397878Phase 2Results posted
• Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon CancerCompletedNCT00217737Phase 3Results posted
• SB-715992 in Treating Patients With Advanced or Metastatic Colorectal CancerCompletedNCT00103311Phase 2Results posted
• Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal CancerCompletedNCT00100841Phase 2Results posted
• Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon CancerCompletedNCT00096278Phase 3Results posted
• Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon CancerCompletedNCT00079274Phase 3Results posted
• Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and ChemotherapyCompletedNCT00004547Phase 2Results posted
• Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF MutationActive, not recruitingNCT05308446Phase 2
• Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing SurgerySuspendedNCT04955808
• A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon CancersCompletedNCT04708470Phase 1/2
• Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH TrialActive, not recruitingNCT04704661Phase 1
• Mobile Sensor Technologies to Assess General Symptomology of People With CancerCompletedNCT04465214
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)Active, not recruitingNCT02465060Phase 2
• Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation TherapyActive, not recruitingNCT02381561Phase 1
• Cancer Symptom Data From Multiple Treatment CentersCompletedNCT01547845
• Testing a Spanish Version of a Patient Toxicity QuestionnaireCompletedNCT01517152
• CT-011 and p53 Genetic Vaccine for Advanced Solid TumorsWithdrawnNCT01386502Phase 1
• Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal CancerCompletedNCT01383343Phase 1
• Evaluation of Cancer Care Coordination in the National Cancer Institutes Community Cancer Center ProgramsCompletedNCT01346280
• AZD6244 With Cetuximab for Solid Tumors and Colorectal CancerCompletedNCT01287130Phase 1
• Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal CancerWithdrawnNCT01270438Phase 2
• Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck CancerCompletedNCT01254617Phase 1
• Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid TumorsTerminatedNCT01233505Phase 1
• Selumetinib and Cetuximab in Treating Patients With Refractory Solid TumorsCompletedNCT01217450Phase 1
• Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal CancerTerminatedNCT01198535Phase 1
• RO4929097 and Capecitabine in Treating Patients With Refractory Solid TumorsCompletedNCT01158274Phase 1
• Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid TumorsCompletedNCT01131234Phase 1
• Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung CancerTerminatedNCT00937482Phase 1
• A Phase 1, Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous Dimethane Sulfonate (DMS612) in Advanced MalignanciesCompletedNCT00923520Phase 1
• Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By SurgeryCompletedNCT00433576Phase 1
• Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal CancerCompletedNCT00397384Phase 1
• Effect of High-Legume Diet on Colorectal Cancer RiskCompletedNCT00339469Early Phase 1
• Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid TumorsCompletedNCT00138177Phase 1
• Sorafenib, Cetuximab, and Irinotecan in Treating Patients With Advanced or Metastatic Colorectal CancerCompletedNCT00134069Phase 1
• Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung CancerCompletedNCT00101348Phase 1/2
• Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid TumorsCompletedNCT00089362Phase 1
• Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With Metastatic Lung Cancer or Metastatic Colorectal CancerTerminatedNCT00088933Phase 1
• EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung CancerTerminatedNCT00087191Not applicable
• GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid TumorsCompletedNCT00084643Phase 1
• Bevacizumab and Cetuximab With or Without Irinotecan in Treating Patients With Irinotecan-Refractory Metastatic Colorectal CancerCompletedNCT00077298Phase 2
• Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Secondary to Colorectal CancerTerminatedNCT00070265Phase 2
• Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Colorectal CancerTerminatedNCT00070122Phase 3
• A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal CancerCompletedNCT00060411Phase 1
• Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal CancerTerminatedNCT00052585Phase 2
• Imatinib Mesylate in Treating Patients With Stage IV Colorectal CancerCompletedNCT00041340Phase 2
• Erlotinib in Treating Patients With Recurrent or Metastatic Colorectal CancerCompletedNCT00032110Phase 2
• 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)CompletedNCT00031681Phase 1
• Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney DysfunctionCompletedNCT00030498Phase 1
• Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic CancerCompletedNCT00028496Phase 1
• Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the LiverCompletedNCT00026234Phase 2
• Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously TreatedCompletedNCT00025337Phase 3
• Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorectal CancerCompletedNCT00023933Phase 1
• Vaccine Therapy in Treating Patients With Metastatic CancerCompletedNCT00020267Phase 1
• Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung CancerCompletedNCT00019006Phase 1
• SU5416 and Irinotecan in Treating Patients With Advanced Colorectal CancerCompletedNCT00005818Phase 1/2
• Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove PolypsCompletedNCT00005094Phase 3
• Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal CancerCompletedNCT00005036Phase 3
• Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon CancerCompletedNCT00004931Phase 3
• Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/NeuCompletedNCT00004074Phase 1
• Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal CancerCompletedNCT00003873Phase 3
• Combination Chemotherapy in Treating Patients With Stage III Colon CancerCompletedNCT00003835Phase 3
• Edrecolomab in Treating Patients With Stage II Colon CancerCompletedNCT00002968Phase 3
• Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal CancerTerminatedNCT00002796Phase 1/2
• A Phase II Clinical Trial of Suppression of Human Antimouse Antibody and Human Antitoxin Response to Immunotoxin LMB-1 by RituximabCompletedNCT00001805Phase 2