Massachusetts General Hospital: Depression trials

The registry lists 171 Depression studies with Massachusetts General Hospital as lead sponsor. 25 are open to participants now and 74 have results posted.

Phase 1 2Phase 2 21Phase 3 8Phase 4 27No phase 114(a study in two phases counts in both)

Studies

Page 2 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• The Association Between Gut Microbiota Diversity and Postpartum DepressionCompletedNCT07227753
• Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural ConnectomeActive, not recruitingNCT06698848Phase 1
• Sequential Multiple Assignment Randomized Trial for Bipolar DepressionActive, not recruitingNCT06433635Phase 4
• Mobile Mental Health Stigma Reduction Intervention Among Black AdultsActive, not recruitingNCT06316804Not applicable
• Researching Heat and Yoga for Mood EnhancementActive, not recruitingNCT06094088Not applicable
• Virtual Reality Intervention for Patients Undergoing BMTActive, not recruitingNCT05629676Not applicable
• Comparing Behavior Therapy and Yoga for Treating Depression Among AdultsCompletedNCT05546697Not applicable
• Peripheral Neuroimmune Mechanisms of HyperthermiaStatus unknownNCT05366270Not applicable
• Pilot Study of a CF-specific CBT Intervention for AdolescentsCompletedNCT05271643Not applicable
• Cannabidiol for Reduction of Brain NeuroinflammationCompletedNCT05066308Phase 2
• Neuromodulation of Mind-Wandering in DepressionActive, not recruitingNCT04832685Not applicable
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)WithdrawnNCT04594616Not applicable
• Transcranial Photobiomodulation for the Treatment of Pediatric DepressionWithdrawnNCT04579185Not applicable
• Mechanism of Action of Transcranial Magnetic StimulationActive, not recruitingNCT04278521Not applicable
• Mechanism of Action of Electroconvulsive TherapyCompletedNCT04059952
• Preventing Depression and Anxiety: A Cystic Fibrosis-Specific Cognitive Behavioral Therapy InterventionCompletedNCT03992027Not applicable
• Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIVCompletedNCT03904186Not applicable
• Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive DisorderSuspendedNCT03787290Phase 2
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), WithdrawnWithdrawnNCT03769350Not applicable
• Comparative Effectiveness of Pharmacogenomics for Treatment of DepressionCompletedNCT03749629Not applicable
• How Body Awareness Promotes Mental Health During Yoga and Physical ExerciseCompletedNCT03553745Not applicable
• Depression and Body Image Distress Following Mastectomy With ReconstructionCompletedNCT03428399
• Neurocognitive Features of Patients With Treatment-Resistant DepressionCompletedNCT03134066
• Pragmatic Collaborative Care for Cardiac Inpatients With Depression or AnxietyCompletedNCT03118752Not applicable
• Preconception and Pregnancy Obesity Treatment and Prevention Among Women With a History of DepressionCompletedNCT03053323Not applicable
• Impact of the Relaxation Response Resiliency Program on Patients With Atrial FibrillationCompletedNCT02634697Not applicable
• Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental IllnessCompletedNCT02594696Not applicable
• Noninvasive Physiologic Sensors to Assess DepressionCompletedNCT02568865
• Examining Cognitive Mechanisms of Clinical Improvement Following Mindfulness Based Therapy for Depressed IndividualsCompletedNCT02457936Not applicable
• Intranasal Ketamine for Late-Life Depression and Suicidal IdeationWithdrawnNCT02295787Phase 4
• Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) StudyCompletedNCT02253225
• Effects of Mindfulness-based Cognitive Therapy on Brain Mechanisms in DepressionCompletedNCT02200341Not applicable
• The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar DepressivesWithdrawnNCT02028026Phase 4
• Comparative Effectiveness Research for Eliminating DisparitiesCompletedNCT02027636Not applicable
• Trial of a Positive Psychology Intervention in Major Depressive DisorderCompletedNCT02004145Not applicable
• Retrospective Medical Record Review of Mind Body Depression Group ParticipantsCompletedNCT01909921
• Using SMART Experimental Design to Personalize Treatment for Child DepressionCompletedNCT01880814Not applicable
• Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese AmericansCompletedNCT01851967Not applicable
• Positive Psychology for Mood DisordersCompletedNCT01820286Not applicable
• Symptom Tracking in Assisted Reproductive TechnologiesCompletedNCT01746797
• Neuroimaging Studies of the Treatment of Bipolar Depression With CitalopramCompletedNCT01639482
• Effectiveness of Acupuncture for Depressed Patients Not Taking Antidepressant MedicationsCompletedNCT01634022Not applicable
• Effectiveness of Acupuncture for Depressed Patients Taking Antidepressant MedicationsCompletedNCT01633996Not applicable
• Therapy for Undergraduate College Students Who Binge Drink and Are DepressedCompletedNCT01632319Not applicable
• Tai Chi Intervention for Chinese Americans With DepressionCompletedNCT01619631Not applicable
• Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderWithdrawnNCT01613820Not applicable
• Potential Use Of Brain Network Activation Analysis to Diagnose Major DepressionTerminatedNCT01579942
• Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 DiabetesCompletedNCT01527981Phase 2
• Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar DepressionStatus unknownNCT01473615Not applicable
• Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for PregnancyCompletedNCT01453114Not applicable
• Effectiveness of a Relaxation-Response Based Cognitive Behavioral Therapy Group for Depressed Chinese PatientsCompletedNCT01359839Not applicable
• Internet-Based Depression Screening for College StudentsCompletedNCT01326793Not applicable
• Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic FeaturesTerminatedNCT01310140
• Culturally-focused Consultation for Asian Americans and Latino AmericansCompletedNCT01239407Not applicable
• Computerized Information-Processing Bias Retraining in Depressed AdolescentsCompletedNCT01147913Phase 2
• Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed ProfessionalsActive, not recruitingNCT01075672Not applicable
• Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major DepressionCompletedNCT00961454Phase 1
• Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study)CompletedNCT00951028Not applicable
• Neuroimaging for DepressionTerminatedNCT00864630Not applicable
• Effectiveness of Telepsychiatry-based Culturally Sensitive Collaborative Treatment of Depressed Chinese AmericansCompletedNCT00854542Not applicable
• Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improvement With Treatment of Depressive SymptomsCompletedNCT00844974Not applicable
• Neural Correlates of Psychodynamic Psychotherapy for DepressionCompletedNCT00812227Not applicable
• Brief CBT for Anxiety and Advanced CancerCompletedNCT00706290Phase 2
• Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I DisorderCompletedNCT00595387Not applicable
• Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral TherapyCompletedNCT00338767Phase 2
• A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)CompletedNCT00321152Phase 4
• Effectiveness of Pramipexole for Treatment-Resistant DepressionCompletedNCT00231959Phase 4
• Culturally Sensitive Collaborative Treatment for Depressed Chinese AmericansCompletedNCT00227929Not applicable
• Bupropion SR for Major Depression and Depression NOS in Children and Adolescents With Bipolar DisorderTerminatedNCT00181896Phase 4
• Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in DepressionCompletedNCT00157547Phase 4
• Testing the Right Question Project (RQP) Health Education Strategy in a Mental Health SettingCompletedNCT00134615Not applicable