Proton Pump Inhibitors: all 885 studies that test it

Page 3 of 9. Open to participants first (51), then studies with results posted, then the rest; newest registration first within each.

• Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot StudyCompletedNCT00693225Phase 4Results posted
• A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED)CompletedNCT00674115Phase 3Results posted
• Rapid Screening Phenotype Test To Evaluate CYP 2C19 Enzyme Activity Using Stable Isotope [13C]PantoprazoleCompletedNCT00668902Not applicableResults posted
• Bronchial Hyper-responsiveness in Reflux CoughTerminatedNCT00668317Phase 3Results posted
• Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study USCompletedNCT00660660Phase 4Results posted
• Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)CompletedNCT00658775Phase 3Results posted
• Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Moderate Erosive Gastroesophageal Reflux Disease (GERD)CompletedNCT00658632Phase 3Results posted
• Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)CompletedNCT00658528Phase 3Results posted
• The Effect of Omeprazole on the Pharmacokinetics of Dasatinib in Healthy SubjectsCompletedNCT00655746Phase 1Results posted
• Use of Topical Budesonide in the Treatment of Eosinophilic EsophagitisCompletedNCT00638456Phase 2Results posted
• Reflux Esophagitis Phase III Study (Maintenance Treatment)CompletedNCT00634114Phase 3Results posted
• Reflux Esophagitis Phase III Study (Initial Treatment)CompletedNCT00633932Phase 3Results posted
• A Study of Dexlansoprazole Modified Release Formulation to Treat Night HeartburnCompletedNCT00627016Phase 3Results posted
• Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced UlcerCompletedNCT00595517Phase 3Results posted
• Does Omeprazole Decrease Intestinal Calcium Absorption?CompletedNCT00582972Phase 4Results posted
• Ulcer Prevention Study in Post Gastric Bypass PatientsCompletedNCT00557349Phase 4Results posted
• A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With EffusionCompletedNCT00546117Not applicableResults posted
• Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAIDCompletedNCT00542789Phase 3Results posted
• The Effects of Reducing Stomach Acid on Post-tonsillectomy PainTerminatedNCT00472186Phase 4Results posted
• A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mgCompletedNCT00464308Phase 4Results posted
• Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD PatientsCompletedNCT00444275Phase 4Results posted
• Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment?CompletedNCT00444145Phase 4Results posted
• Lansoprazole to Treat Children With AsthmaCompletedNCT00442013Phase 4Results posted
• Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA)CompletedNCT00441727Phase 3Results posted
• Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal PatientsCompletedNCT00427635Phase 3Results posted
• Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric UlcerCompletedNCT00401752Phase 3Results posted
• Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal RefluxTerminatedNCT00369265Phase 4Results posted
• Study Evaluating the Efficacy and Safety of Pantoprazole in Infants With Symptomatic Gastroesophageal Reflux Disease (GERD)CompletedNCT00365300Phase 3Results posted
• Study Evaluating Pantoprazole in Neonates and Preterm Infants With GERDCompletedNCT00362609Phase 3Results posted
• Elucidation of Acid-Induced Pulmonary InflammationTerminatedNCT00361972Phase 2/3Results posted
• Efficacy of Lansoprazole in Chronic Post Nasal DripCompletedNCT00335283Phase 3Results posted
• Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux DiseaseCompletedNCT00321984Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole MR Compared to Placebo on Maintaining Healing in Subjects With Healed Erosive EsophagitisCompletedNCT00321737Phase 3Results posted
• Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux AsthmaCompletedNCT00317044Phase 2Results posted
• The Utility of Nexium in Chronic Cough and Reflux DiseaseCompletedNCT00287339Phase 4Results posted
• Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat HeartburnCompletedNCT00255190Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole MR on Maintaining Healing in Subjects With Healed Erosive EsophagitisCompletedNCT00255164Phase 3Results posted
• Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive EsophagitisCompletedNCT00255151Phase 3Results posted
• A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic UlcerCompletedNCT00251979Phase 3Results posted
• Esomeprazole (NEXIUM) vs. SurgeryCompletedNCT00251927Phase 3Results posted
• Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat HeartburnCompletedNCT00251758Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole Modified Release Formulation to Treat HeartburnCompletedNCT00251745Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive EsophagitisCompletedNCT00251719Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive EsophagitisCompletedNCT00251693Phase 3Results posted
• E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent SufferersCompletedNCT00236197Phase 3Results posted
• E3810-A001-313: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent SufferersCompletedNCT00236184Phase 3Results posted
• Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD PatientsCompletedNCT00222131Phase 2Results posted
• Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux DiseaseCompletedNCT00215787Not applicableResults posted
• Nexium Study To Suppress Nausea During ChemotherapyTerminatedNCT00206440Phase 3Results posted
• Treatment of Zollinger-Ellison Syndrome With PrevacidCompletedNCT00204373Phase 4Results posted
• Maintenance Intermittent Therapy for Symptomatic GERD PatientsCompletedNCT00165841Phase 2Results posted
• A Study of E3810 With Pre- and Post-Treatment pH Monitoring in Patients With Non-Erosive Gastroesophageal Reflux DiseaseCompletedNCT00165672Phase 3Results posted
• A Comparative Study on the Efficacy and Safety of E3810 in Patients With Non-erosive Gastroesophageal Reflux DiseaseCompletedNCT00165646Phase 3Results posted
• Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With RabeprazoleCompletedNCT00132496Phase 2Results posted
• Study of Acid Reflux in AsthmaCompletedNCT00069823Phase 3Results posted
• Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor UsersCompletedNCT07852676Phase 4
• A Study on the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of HMPL-760 CapsulesCompletedNCT07643272Phase 1
• Study to Evaluate the Effect of Rabeprazole Sodium Enteric-coated Tablets on the Pharmacokinetics of TQ05105 TabletsActive, not recruitingNCT07608666Phase 1
• A Study to Learn How Different Forms of the Study Medicine Called PF-08049820 Are Absorbed and Eliminated in Healthy AdultsCompletedNCT07597928Phase 1
• Comparison of Esomeprazole Versus Vonoprazan in Gastroesophageal Reflux DiseaseCompletedNCT07563491Not applicable
• Gastroprotective Efficacy of Rebamipide in Patients With Atrial Fibrillation Treated With DOACsCompletedNCT07354230Phase 4
• Comparative Effectiveness of Triple Versus Quadruple Therapy in the Treatment of Helicobacter Pylori Induced GastritisCompletedNCT07312721Phase 4
• A Study to Learn if a Medicine That Reduces Stomach Acid Affects the Blood Level of Study Medicine PF-08049820 in Healthy Chinese Adults.CompletedNCT07284173Phase 1
• Pharmacokinetics of Clozapine and Norclozapine and the Effect of PantoprazoleCompletedNCT07262736Phase 1
• Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult ParticipantsCompletedNCT07235748Phase 1
• Helicobacter Pylori Infection and Gastric Disease in Bhutan: First Community-Wide, Population-Based StudyCompletedNCT07211880Not applicable
• Evaluate the Effects of Famotidine or Rabeprazole on the PK of NirogacestatCompletedNCT07171619Phase 1
• Effects of Omeprazole Ingestion on Postprandial Amino Acid Concentrations in Response to a Mixed MealCompletedNCT07142486Not applicable
• Evaluation of the Efficacy and Safety of Eolo in Patients With NERDCompletedNCT07041060Not applicable
• Drug-drug Interaction Study of Omeprazole and Bemnifosbuvir/RuzasvirCompletedNCT07007806Phase 1
• A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omeprazole on the Pharmacokinetics of AZD4144 in Healthy ParticipantsCompletedNCT06948006Phase 1
• Comparison of the Efficacies of Two Novel Dose Dual Therapies in the First-line Helicobacter Pylori EradicationStatus unknownNCT06811207Phase 3
• Clinical Study Aiming to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Administration of ZE50-0134 at 5 Dose Levels in Healthy VolunteersCompletedNCT06787131Phase 1
• Therapeutic Effect of Vonoprazan Versus Dexlansoprazole in Treatment of Gastroesophageal Reflux DiseaseCompletedNCT06778395Phase 4
• Study to Evaluate Pharmacokinetic and Pharmacodynamic Drug Interactions and Safety of IY-NS250 and IY-NT-SRCompletedNCT06725992Phase 1
• A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003)CompletedNCT06619314Phase 1
• A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult ParticipantsCompletedNCT06605950Phase 1
• A Study in Healthy Men to Test Whether Esomeprazole Influences the Amount of BI 3000202 in the BloodCompletedNCT06419660Phase 1
• Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter PyloriCompletedNCT06414707Phase 3
• Study of Single and Multiple Ascending Doses of ZE46-0134 in Healthy VolunteersCompletedNCT06399315Phase 1
• A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy ParticipantsCompletedNCT06378658Phase 1
• A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive EfficacyCompletedNCT06378398Early Phase 1
• A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult ParticipantsCompletedNCT06366243Phase 1
• Metformin and Esomeprazole in Preterm Pre-eclampsiaTerminatedNCT06359015Phase 4
• A Clinical Trial to Evaluate a High-Fat Meal and Omeprazole Enteric-coated Tablets on ASBK021CompletedNCT06322706Phase 1
• Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in EgyptiansCompletedNCT06315478Phase 4
• A Study to Learn If the Study Medicine Esomeprazole Changes How the Body Processes the Other Study Medicine VepdegestrantCompletedNCT06275841Phase 1
• Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori InfectionCompletedNCT06250634Not applicable
• A Study in Healthy People to Compare Two Different Tablets of BI 685509 and to Test How Food and Esomeprazole Influence the Amount of BI 685509 in the BloodCompletedNCT06193811Phase 1
• Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and RifampinCompletedNCT06031454Phase 1
• A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121CompletedNCT06025773Phase 1
• A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy ParticipantsCompletedNCT05932277Phase 1
• HMPL-453 Food Effect and PPI Study in Healthy Volunteer StudyCompletedNCT05930119Phase 1
• Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among ChildrenCompletedNCT05861687Phase 2/3
• Bioequivalence Study of 20 mg Omeprazole Capsules in Indonesia Healthy SubjectCompletedNCT05849883Not applicable
• A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer BleedingCompletedNCT05841394Phase 3
• A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy ParticipantsCompletedNCT05826574Phase 1
• Medicine-induced Cardiac Hemodialysis on COVID-19CompletedNCT05711810Phase 4
• A Study of IBI351 in Healthy SubjectsCompletedNCT05688124Phase 1
• The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer PatientsCompletedNCT05680870Phase 3

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