Proton Pump Inhibitors: all 885 studies that test it

Page 1 of 9. Open to participants first (51), then studies with results posted, then the rest; newest registration first within each.

• Assessing the Effect of a Proton Pump Inhibitor on the Pharmacokinetics of DZD8586 in Healthy Participants (TAI-SHAN21)Not yet recruitingNCT07888569Phase 1
• A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy AdultsNot yet recruitingNCT07875842Phase 1
• A Study to Investigate the Effect of Omeprazole and Cyclosporine on Velzatinib in Healthy ParticipantsNot yet recruitingNCT07862114Phase 1
• Effect of Omeprazole on Gut Microbiota in Adults With Obesity and GERDNot yet recruitingNCT07850960Phase 4
• Efficacy And Safety of Bismuth-Tetracycline-Rabeprazole Triple For First-Line Eradication of Helicobacter Pylori InfectionNot yet recruitingNCT07788053Not applicable
• Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia CasesRecruitingNCT07750379Not applicable
• A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male ParticipantsNot yet recruitingNCT07683793Phase 1
• The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)RecruitingNCT07488299Not applicable
• Effect of ZaStaprazan on Platelet Reactivity of Clopidogrel After PercuTaneous CoronAry InteRventionRecruitingNCT07471867Phase 4
• Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple TherapyRecruitingNCT07358130Not applicable
• Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori InfectionRecruitingNCT07275827Phase 3
• Pantoprazole After Prophylactic Endoscopic Variceal TreatmentEnrolling by invitationNCT07248722Not applicable
• Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation TherapyNot yet recruitingNCT07076914Phase 2
• Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori InfectionNot yet recruitingNCT07040839Phase 4
• Efficacy of Ketorolac for Postoperative Pain Management in Hip ArthroscopyRecruitingNCT07037888Phase 4
• Immunochemotherapy ± Salvage Chemoradiation for Local Recurrence of Esophageal Squamous Cell Carcinoma After Definitive ChemoradiotherapyEnrolling by invitationNCT07016737Phase 3
• Effect of Triple Versus Quadruple Therapy for Treating Helicobacter Pylori InfectionEnrolling by invitationNCT07010744Not applicable
• A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 WeeksRecruitingNCT06953986Not applicable
• PPIs and In-Hospital Morbidity in Acute Variceal Bleeding With Chronic Liver DiseaseRecruitingNCT06861478Phase 2
• A Phase III Clinical Trial for Efficacy and Safety Evaluation of JP-1366 Tablets on Reflux EsophagitisRecruitingNCT06850480Phase 3
• Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.RecruitingNCT06778824Not applicable
• Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)RecruitingNCT06706258Phase 2
• Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail ApproachRecruitingNCT06693960Early Phase 1
• Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin LactoneRecruitingNCT06690164Phase 4
• Luminal Fructose Kinetics (MARTINI Study)RecruitingNCT06539494Phase 2
• Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock PatientsRecruitingNCT06531642Phase 2/3
• Optimal Duration of Bismuth Quadruple Therapy for Helicobacter Pylori Eradication in Females As Compared with MalesEnrolling by invitationNCT06509139Phase 4
• Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic SurgeryRecruitingNCT06488001Phase 2
• Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous ThromboembolismRecruitingNCT06393868Phase 3
• Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs EsomeprazoleNot yet recruitingNCT06318104Phase 4
• Clinical Study Evaluating the Safety and Efficacy of Esomeprazole in Treatment of Non-alcoholic SteatohepatitisRecruitingNCT06302049Phase 1/2
• Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic UlcerRecruitingNCT06284876Phase 3
• The ESG Integrity Study: Effect of Proton Pump Inhibitors on the Structural Integrity of Endoscopic Sleeve GastroplastyRecruitingNCT06283381Phase 4
• Treatment of Gastroesophageal Reflux Disease in InfantsRecruitingNCT06255886Phase 4
• Esomeprazole and Radiation Induced EsophagitisRecruitingNCT06120803Phase 2
• GERD Infant Feeding Therapeutics Trial (GIFT Trial)RecruitingNCT06114836Not applicable
• Levofloxacin Concomitant Versus Levofloxacin SequentialNot yet recruitingNCT06065267Phase 4
• Role of Octreotide in Non Variceal BleedingRecruitingNCT06062719Phase 2/3
• A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of ChileRecruitingNCT05926804Not applicable
• The Efficacy and Safty of Proton Pump Inhibitor (Lansoprazole)Not yet recruitingNCT05820048Phase 4
• OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal UlcersRecruitingNCT05799105Phase 4
• Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical TrialNot yet recruitingNCT05726734Phase 4
• Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal BleedingNot yet recruitingNCT05624229Phase 4
• Metformin and Esomeprazole For Preterm Pre-eclampsiaNot yet recruitingNCT05232994Phase 1
• Treating People With Idiopathic Pulmonary Fibrosis With the Addition of LansoprazoleRecruitingNCT04965298Phase 3
• The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori EradicationEnrolling by invitationNCT04527055Phase 4
• Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled TrialRecruitingNCT04448028Phase 4
• High Dose Oral Omeprazole in High Risk UGIBRecruitingNCT04394663Not applicable
• Fatty Acid Synthase Inhibition in Castration Refractory Prostate CancerRecruitingNCT04337580Phase 2
• A Study of Esomeprazole in Children With AutismRecruitingNCT03866668Phase 2
• Efficacy of Proton Pump Inhibitors in Gastrointestinal Erosions and/or UlcersRecruitingNCT03315676Phase 2
• A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the BodyCompletedNCT06494761Phase 1Results posted
• Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump InhibitorCompletedNCT06154226Phase 2Results posted
• A Study of Maribavir Pediatric Formulation in Healthy Adult ParticipantsCompletedNCT05918822Phase 1Results posted
• Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of CamlipixantCompletedNCT05899829Phase 1Results posted
• A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver CirrhosisCompletedNCT05741385Not applicableResults posted
• A Study to Evaluate the Impact of Omeprazole on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy VolunteersCompletedNCT05497557Phase 1Results posted
• A Relative Bioavailability Study Evaluating Two New Encorafenib FormulationsCompletedNCT05446142Phase 1Results posted
• A Study in Healthy Men to Compare Two Different Oral Formulations of BI 1810631 and to Test How Food or Rabeprazole Influence the Amount of BI 1810631 in the BloodCompletedNCT05380947Phase 1Results posted
• A Study of ALXN1840 (Coated and Non-coated) Administered With And Without Omeprazole In Healthy AdultsCompletedNCT05319912Phase 1Results posted
• A Study of ALXN1840 (Non-coated) Administered With And Without Omeprazole In Healthy AdultsCompletedNCT05319899Phase 1Results posted
• Bioequivalence Study of Esomeprazole 20 Milligram (mg) Delayed-Release Capsules in Healthy Adult ParticipantsCompletedNCT05265247Phase 1Results posted
• Role of Proton Pump Inhibitors on the Postoperative Course Following PancreaticoduodenectomyTerminatedNCT05251233Phase 2Results posted
• Study of the Effect of Food and a Proton Pump Inhibitor (PPI; Omeprazole) on LOXO-305 in Healthy ParticipantsCompletedNCT05134350Phase 1Results posted
• A Study of LY3484356 in Healthy Female ParticipantsCompletedNCT04840888Phase 1Results posted
• PROUD Study - Preventing Opioid Use DisordersTerminatedNCT04766996Phase 4Results posted
• A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the BloodCompletedNCT04679948Phase 1Results posted
• Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy AdultsCompletedNCT04425902Phase 1Results posted
• Effect of Obesity on Proton Pump InhibitorsCompletedNCT04248335Phase 4Results posted
• Interaction Between Omeprazole and Gliclazide in CYP2C19 Normal/ Ultrarapid MetabolisersCompletedNCT04198948Phase 1Results posted
• A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy VolunteersCompletedNCT04156646Phase 1Results posted
• Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult ParticipantsCompletedNCT03866434Phase 1Results posted
• A Trial to Evaluate the Effect of the Proton Pump Inhibitor Esomeprazole on the Single-dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult ParticipantsCompletedNCT03849690Phase 1Results posted
• A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal UlcerCompletedNCT03553563Phase 3Results posted
• Proton Pump Inhibitors (PPI) and Fat Absorption in Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)CompletedNCT03551691Phase 2Results posted
• Effect of a Proton Pump Inhibitor on the PK of TepotinibCompletedNCT03531762Phase 1Results posted
• Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy VolunteersCompletedNCT03530995Phase 1Results posted
• Gastric Acid Suppression and Probiotic ColonizationCompletedNCT03327051Phase 4Results posted
• A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese ParticipantsCompletedNCT03316976Phase 1Results posted
• PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)CompletedNCT03175731Phase 4Results posted
• A Study to Evaluate the Bioequivalence of Single Oral Dose of Esomeprazole Capsule and Tablet Formulation in Healthy ParticipantsCompletedNCT03083639Phase 1Results posted
• Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori InfectionCompletedNCT03050359Phase 3Results posted
• Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Gastric Ulcer Participants With or Without Helicobacter Pylori InfectionCompletedNCT03050307Phase 3Results posted
• Levofloxacin Triple and Bismuth Quadruple Therapies for Rescue Treatment of H Pylori InfectionCompletedNCT02978157Not applicableResults posted
• Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)CompletedNCT02950259Phase 1Results posted
• Efficacy and Safety of Dexlansoprazole in Healing and Maintaining Healing of Erosive EsophagitisTerminatedNCT02873702Phase 3Results posted
• Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese PatientsCompletedNCT02873689Phase 3Results posted
• Implementation of PPI Medication PGX TestingCompletedNCT02794844Phase 4Results posted
• Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and DigoxinCompletedNCT02783040Phase 1Results posted
• Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor TreatmentCompletedNCT02708355Phase 4Results posted
• A Study of Abemaciclib in Participants With Cancer That is Advanced or Has Spread to Another Part(s) of the BodyCompletedNCT02688088Phase 1Results posted
• Role of Pepsin Assay in Wheezy InfantsCompletedNCT02685436Phase 4Results posted
• Symptom Control Satisfaction With Proton Pump Inhibitor RegimenCompletedNCT02623816Phase 4Results posted
• Bioequivalence Study of Raperazole 20mg DR Tabs and PARIET® 20 mg DR Tabs Under Fed ConditionsCompletedNCT02605395Phase 4Results posted
• Inhibiting Fatty Acid Synthase to Improve Efficacy of Neoadjuvant ChemotherapyCompletedNCT02595372Phase 2Results posted
• Comparison of Two Rescue Therapies for Helicobacter Pylori InfectionCompletedNCT02547012Not applicableResults posted
• Comparison of Hybrid and Bismuth Quadruple Therapies for Helicobacter Pylori EradicationCompletedNCT02541864Not applicableResults posted
• A Study Evaluating the Effect of Esomeprazole on SYN-004 Degradation of Ceftriaxone In Adults With an IleostomyCompletedNCT02473640Phase 1/2Results posted
• Stress Ulcer Prophylaxis in the Intensive Care UnitCompletedNCT02467621Phase 4Results posted
• A Bioequivalence Study of Idiazole 20mg DR Tabs and PARIET® 20 mg DR Tabs After a Single Oral Dose Administration Under Fasting Conditions in Healthy AdultsCompletedNCT02446483Phase 4Results posted

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