Protein Kinase Inhibitors: all 15,766 studies that test it

Page 27 of 158. Open to participants first (2,605), then studies with results posted, then the rest; newest registration first within each.

• Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or NilotinibRecruitingNCT01746836Phase 2
• Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL ActivityRecruitingNCT01639508Phase 2
• A Phase I/II Trial of Vemurafenib and Metformin to Melanoma PatientsRecruitingNCT01638676Phase 1/2
• Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer TissueRecruitingNCT01294072Not applicable
• I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast CancerRecruitingNCT01042379Phase 2
• A TQT Study of Effect of M2951 on Cardiac RepolarizationCompletedNCT07214935Phase 1Results posted
• Relative Bioavailability of Evobrutinib Tablet BatchesCompletedNCT07214922Phase 1Results posted
• Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and NintedanibCompletedNCT06717100Phase 1Results posted
• A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic CancerTerminatedNCT06630325Phase 2Results posted
• A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the BloodCompletedNCT06504862Phase 1Results posted
• A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the BodyCompletedNCT06494761Phase 1Results posted
• A Study Evaluating Deucravacitinib Concentrations in the Breast Milk and Plasma of Healthy Lactating Female ParticipantsCompletedNCT06476834Phase 4Results posted
• Study To Evaluate The Efficacy Of Tofacitinib In Patients With SJS/TENCompletedNCT06474078Not applicableResults posted
• A Study to Investigate 14C-bemcentinib in Healthy Male SubjectsCompletedNCT06469138Phase 1Results posted
• A Study to Learn About the Study Medicine PF-07220060 Together With Letrozole Compared to Letrozole Alone in Women Post MenopauseCompletedNCT06465368Phase 2Results posted
• Deucravacitinib (BMS-986165) for Pityriasis Rubra PilarisCompletedNCT06444399Phase 2Results posted
• Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)Active, not recruitingNCT06400251Phase 2Results posted
• Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)Active, not recruitingNCT06400238Phase 2Results posted
• Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)Active, not recruitingNCT06390852Phase 2Results posted
• Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)Active, not recruitingNCT06390839Phase 2Results posted
• Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)Active, not recruitingNCT06390826Phase 2Results posted
• Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)Active, not recruitingNCT06385483Phase 2Results posted
• A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Participants.CompletedNCT06385119Phase 1Results posted
• High-protein Oral Supplement With Liposomal Curcumin in Adults Undergoing Hemodialysis.CompletedNCT06381076Phase 3Results posted
• Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)Active, not recruitingNCT06360588Phase 2Results posted
• Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)Active, not recruitingNCT06360575Phase 2Results posted
• Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)Active, not recruitingNCT06357975Phase 2Results posted
• Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Mutations or Fusions (MATCH - Subprotocol K2)Active, not recruitingNCT06351371Phase 2Results posted
• Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)Active, not recruitingNCT06308822Phase 2Results posted
• Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)Active, not recruitingNCT06303167Phase 2Results posted
• A Study to Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy AdultsCompletedNCT06267963Phase 1Results posted
• A Study of Two Different Formulations of Pirtobrutinib (LOXO-305) In Healthy ParticipantsCompletedNCT06258174Phase 1Results posted
• A Study to Evaluate the Efficacy, and Safety Study of Ruxolitinib Cream in Adults With Moderate Atopic DermatitisCompletedNCT06238817Phase 3Results posted
• LIONS (PLK4 Inhibitor in Advanced Solid Tumors)TerminatedNCT06232408Phase 1Results posted
• A Study to Evaluate the Effect of Pirtobrutinib (LOXO-305) on QTc Interval in Healthy ParticipantsCompletedNCT06215521Phase 1Results posted
• A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy ParticipantsCompletedNCT06215430Phase 1Results posted
• A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.Active, not recruitingNCT06206837Phase 1/2Results posted
• Effectiveness and Safety of Tofacitinib in Patients With Recalcitrant Frontal Fibrosing Alopecia : A Pilot StudyCompletedNCT06202560Not applicableResults posted
• CX-4945 in Viral Community Acquired PneumoniaTerminatedNCT06202521Phase 2Results posted
• A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy ParticipantsCompletedNCT06194214Phase 1Results posted
• Safety of Bryostatin in Patients With MSTerminatedNCT06190912Phase 1Results posted
• Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy ParticipantsCompletedNCT06190691Phase 1Results posted
• Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy ParticipantsCompletedNCT06190678Phase 1Results posted
• A Study to Evaluate Pirtobrutinib (LOXO-305) in Healthy Adult ParticipantsCompletedNCT06181006Phase 1Results posted
• A Study of the Effect of Food on Pirtobrutinib (LOXO-305) in Healthy ParticipantsCompletedNCT06180980Phase 1Results posted
• A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Different Formulations of Midazolam in Healthy ParticipantsCompletedNCT06180967Phase 1Results posted
• A Study of Carbon-14-Labelled [14C] LOXO-305 (Pirtobrutinib) in Healthy Male ParticipantsCompletedNCT06180954Phase 1Results posted
• A Study to Learn About Three Forms of The Study Medicine (Ritlecitinib) in Healthy AdultsCompletedNCT06172348Phase 1Results posted
• A Study of the Effects of Pirtobrutinib (LOXO-305) on Repaglinide (CYP2C8 Substrate) in Healthy ParticipantsCompletedNCT06165146Phase 1Results posted
• Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ FunctionActive, not recruitingNCT06145282Phase 1/2Results posted
• A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic KeratosisCompletedNCT06135415Phase 3Results posted
• A Study to Compare the Relative Bioavailability of Brigatinib When Swallowed as a Solution Versus When Swallowed as a Tablet in Healthy AdultsCompletedNCT06132867Phase 1Results posted
• A Study of Deucravacitinib to Treat LPP and FFACompletedNCT06091956Phase 2Results posted
• A Study in Healthy Men to Test How Zongertinib is Taken up in the Body When Taken With or Without FoodCompletedNCT06075277Phase 1Results posted
• A Study in Healthy Men to Test Whether BI 1015550 Influences the Amount of Nintedanib and Pirfenidone in the BloodCompletedNCT06070610Phase 1Results posted
• A Study to Evaluate Effectiveness and Safety of Deucravacitinib in Participants With Non-Pustular Palmoplantar and Genital PsoriasisTerminatedNCT06042920Phase 4Results posted
• Maribavir vs. Valganciclovir for CMV Prophylaxis in High-Risk Kidney Transplant RecipientsCompletedNCT06034925Phase 4Results posted
• A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Zongertinib in the BloodCompletedNCT06028464Phase 1Results posted
• TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast CancerActive, not recruitingNCT06001762Phase 2Results posted
• JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow FailureActive, not recruitingNCT05998408Phase 1/2Results posted
• JAK/STAT Inhibition in CNS Kohlmeier-Degos DiseaseCompletedNCT05998395Phase 1/2Results posted
• Evaluating the Safety and Efficacy of Deucravacitinib Compared to Placebo Hidradenitis Suppurativa (HS).TerminatedNCT05997277Phase 2Results posted
• Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR InhibitorsCompletedNCT05997056Phase 2Results posted
• A Study to Prevent Rash in People Starting Alpelisib for the Treatment of Breast CancerTerminatedNCT05966584Phase 2Results posted
• A Study of INCB099280 in Combination With Axitinib in Adults With Advanced Solid TumorsTerminatedNCT05949632Phase 1/2Results posted
• Study Evaluating the Efficacy and Safety of Povorcitinib in Adults With Chronic Spontaneous UrticariaCompletedNCT05936567Phase 2Results posted
• A Study of Maribavir Pediatric Formulation in Healthy Adult ParticipantsCompletedNCT05918822Phase 1Results posted
• A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy ParticipantsCompletedNCT05906836Phase 1Results posted
• Topical Ruxolitinib Evaluation in Chronic Hand EczemaCompletedNCT05906628Phase 2Results posted
• A Study in Healthy Men to Test How Zongertinib (BI 1810631) is Taken up and Processed by the BodyCompletedNCT05879991Phase 1Results posted
• RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy BodiesCompletedNCT05869669Phase 2Results posted
• A Study to Assess Two Forms of The Study Medicine (Ritlecitinib) in Healthy Adult ParticipantsCompletedNCT05852340Phase 1Results posted
• A Study in Healthy Men to Test How Itraconazole Influences the Amount of Zongertinib (BI 1810631) in the BloodCompletedNCT05833139Phase 1Results posted
• ME-344 and Bevacizumab in Previously Treated Metastatic Colorectal CancerTerminatedNCT05824559Phase 1Results posted
• A Study of Silmitasertib (CX-4945) in Healthy SubjectCompletedNCT05817708Phase 1Results posted
• Bioequivalence Binimetinib 3 x 15 mg and 45 mg FormulationsCompletedNCT05810740Phase 1Results posted
• Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)Active, not recruitingNCT05804045Phase 3Results posted
• Myositis Interstitial Lung Disease Nintedanib TrialCompletedNCT05799755Phase 4Results posted
• A Multicenter, Open-label Phase 3 Study: Ambulatory Blood Pressure Monitoring in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Treated With Remibrutinib up to 12 Weeks.CompletedNCT05795153Phase 3Results posted
• Ruxolitinib in Seborrheic DermatitisCompletedNCT05787860Phase 2Results posted
• A Study of TAS3351 in NSCLC Patients With EGFRmtTerminatedNCT05765734Phase 1Results posted
• Rigosertib Plus Pembrolizumab in Treating Patients With Unresectable/Metastatic Melanoma Refractory to PD-1 InhibitorsTerminatedNCT05764395Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)CompletedNCT05764161Phase 3Results posted
• A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)CompletedNCT05755438Phase 3Results posted
• A Study to Assess the Safety and Efficacy of Ruxolitinib Cream in Participants With Genital VitiligoCompletedNCT05750823Phase 2Results posted
• A Study of Tirbanibulin on the Wellbeing of Participants With Actinic KeratosesCompletedNCT05741294Phase 4Results posted
• A Study to Evaluate Effectiveness and Safety of BMS-986322 in Participants With Moderate-to-Severe PsoriasisCompletedNCT05730725Phase 2Results posted
• Deucravacitinib for the Treatment of Palmoplantar PustulosisTerminatedNCT05710185Phase 4Results posted
• A Study to Evaluate the Effect of Deucravacitinib on Quality of Life in Participants With Plaque Psoriasis in a Community SettingCompletedNCT05701995Phase 4Results posted
• The Purpose of This Study is to Evaluate the Effects of Ruxolitinib Cream on Adults With Atopic Dermatitis Experiencing Sleep Disturbance.TerminatedNCT05696392Phase 4Results posted
• A Study to Assess the Safety and Pharmacokinetics of GDC-8264 in Combination With Standard of Care in Participants With Acute Graft-Versus-Host Disease (aGVHD)CompletedNCT05673876Phase 1Results posted
• A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002)CompletedNCT05673460Phase 1Results posted
• A Study to Learn How Well the Study Treatment Zabedosertib (BAY1834845) Works and How Safe it is Compared to Placebo in Adult Participants With Moderate-to-severe Atopic DermatitisCompletedNCT05656911Phase 2Results posted
• Janus Kinase Inhibition in Granuloma AnnulareCompletedNCT05650736Phase 2Results posted
• A Study to Learn About the Study Medicine (Called Ritlecitinib) For the Potential Treatment of Severe Alopecia Areata (AA) In Children 6 To Less Than 12 Years of AgeCompletedNCT05650333Phase 1Results posted
• Study to Evaluate of the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis SuppurativaCompletedNCT05635838Phase 2Results posted
• Study to Assess the Safety of Alpelisib Plus Fulvestrant, in Men and Post-menopausal Women With HR-positive, HER2-negative, Advanced Breast Cancer (aBC) With PIK3CA Mutation, Whose Disease Progressed on or After Endocrine TreatmentCompletedNCT05631795Phase 4Results posted
• Study on Safety and Efficacy of NMS-01940153E in Adult Patients With Unresectable Hepatocellular Carcinoma (HCC) Previously Treated With Systemic TherapyTerminatedNCT05630937Phase 1/2Results posted
• A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple SclerosisTerminatedNCT05630547Phase 2Results posted
• A Study of Absorption, Metabolism, Excretion, and Absolute Bioavailability of Carbon-14-Labelled [14C] Selpercatinib (LY3527723) in Healthy Male ParticipantsCompletedNCT05630287Phase 1Results posted

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