Drug
Pretomanid clinical trials
Also written PA-824.
- studies test it
- 33
- open now
- 6
- in phase 3
- 9
- first study started
- 2006
Keep track of what changes. Save the pretomanid studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
33 studies that test it; most in 2012 (4)
| Year | Studies |
|---|---|
| 2006 | 1 |
| 2007 | 2 |
| 2009 | 3 |
| 2010 | 1 |
| 2012 | 4 |
| 2014 | 1 |
| 2015 | 3 |
| 2017 | 2 |
| 2018 | 2 |
| 2020 | 2 |
| 2021 | 2 |
| 2023 | 4 |
| 2024 | 2 |
| 2025 | 3 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 10
- Phase 2
- 18
- Phase 3
- 9
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 0 · Other 33
Global Alliance for TB Drug Development (18) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · Medecins Sans Frontieres, Netherlands (2) · The Aurum Institute NPC (1) · Tuberculosis Research Centre, India (1) · Johns Hopkins University (1) · Wuhan Pulmonary Hospital (1) · University College, London (1)
Often tested with
Tested in the same studies.
Bedaquiline (14) · Moxifloxacin (11) · Linezolid (9) · Pyrazinamide (9) · Rifampin (3) · TBAJ-876 (2) · Isoniazid (2) · PNU-100480 (2)
Studies
Open first, then newest update. How each study uses pretomanid is read from its arms, and is right about nine times in ten.
Testing it · 33
- Trial of Novel Regimens for the Treatment of Pulmonary TuberculosisRecruitingPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT06192160Written as Pretomanid
- Platform Assessing Regimens and Durations In a Global Multisite Consortium for TBRecruitingPhase 2University College, LondonNCT06114628Written as Pretomanid (Pa)
- Program for Rifampicin-Resistant Disease With Stratified Medicine for TuberculosisRecruitingPhase 2/3University of California, San FranciscoNCT06441006Written as Pretomanid
- Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TBRecruitingPhase 2Global Alliance for TB Drug DevelopmentNCT07672405Written as Pretomanid
- PanACEA - STEP2C -01RecruitingPhase 2Michael HoelscherNCT05807399Written as Pretomanid (Pa)
- A Study on the Short-course Treatment Regimen Containing Pretomanid for Drug-resistant TuberculosisNot yet recruitingNot applicableWuhan Pulmonary HospitalNCT07126639Written as Pretomanid (Pa)
- Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant TuberculosisCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT05586230Written as Pretomanid
- Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult PatientsCompletedPhase 2/3Global Alliance for TB Drug DevelopmentNCT03338621Written as Pretomanid
- Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal FunctionCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT03896750Written as PA-824
- Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary TuberculosisActive, not recruitingPhase 2Global Alliance for TB Drug DevelopmentNCT06058299Written as Pretomanid
- A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TBCompletedPhase 3Global Alliance for TB Drug DevelopmentNCT02333799Written as PA-824
- Pretomanid in Adults With Hepatic ImpairmentTerminatedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT02422524Written as PA-824
- A Pan-TB Regimen Targeting Host and MicrobeActive, not recruitingPhase 2/3The Aurum Institute NPCNCT05686356Written as Pretomanid
- A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary TuberculosisCompletedPhase 2Global Alliance for TB Drug DevelopmentNCT04179500Written as Pretomanid
- Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of PretomanidCompletedPhase 1Global Alliance for TB Drug DevelopmentNCT04309656Written as Pretomanid
- Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)CompletedPhase 2/3Medecins Sans Frontieres, NetherlandsNCT02589782Written as Pretomanid
- Economic Evaluation of New MDR TB RegimensCompletedPhase 2/3Medecins Sans Frontieres, NetherlandsNCT04207112Written as Pretomanid
- Modified BPaL Regimen for Managing Pre-XDR TB and MDR (TI/NR) TB in IndiaActive, not recruitingPhase 3Tuberculosis Research Centre, IndiaNCT05040126Written as Pretomanid
- Assessing PA-824 for Tuberculosis (the APT Trial)CompletedPhase 2Johns Hopkins UniversityNCT02256696Written as PA-824
- Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant TuberculosisCompletedPhase 3Global Alliance for TB Drug DevelopmentNCT03086486Written as Pretomanid
See all 33 studies that test pretomanid →
Given in every arm · 4 — pretomanid is usual care beside what is tested
- Study of Combinations of Novel Promising Drugs for Pulmonary TuberculosisNot yet recruitingPhase 2TASK Applied ScienceNCT07773610Written as Pretomanid 200mg
- Bactericidal Activity and Safety of Nicotinamide in Combination With Bedaquiline, Pretomanid, and Linezolid in Drug-susceptible Pulmonary TuberculosisSuspendedPhase 2Gates Medical Research InstituteNCT07517445Written as Bedaquiline, pretomanid, linezolid
- Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary TuberculosisCompletedPhase 2GlaxoSmithKlineNCT05382312Written as Pretomanid
- PRACTECAL-PKPD Sub StudyStatus unknownPhase 2/3Medecins Sans Frontieres, NetherlandsNCT04081077Written as Pretomanid
As the comparator · 3 — what is tested is compared with pretomanid
- Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary TuberculosisRecruitingPhase 2Gates Medical Research InstituteNCT07525427Written as Bedaquiline, pretomanid and linezolid
- A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary TuberculosisRecruitingPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT07209761Written as BPaL
- A PAN-USR TB Multi-Center TrialRecruitingPhase 3Shenzhen Third People's HospitalNCT06905522Written as Pretomanid (Pa)
Codes
What other systems call pretomanid · ClinicalTrials.gg INT004249
- MeSH (NLM) C410767pretomanidOne source ClinicalTrials.gov
- UNII (FDA) 2XOI31YC4NPRETOMANIDConfirmed FDA, Wikidata
- RxNorm 2198359One source FDA
- Wikidata Q7118312pretomanidConfirmed FDA, Wikidata
- NCI Thesaurus C166606PretomanidOne source FDA
- DrugBank DB05154One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C410767 | pretomanid | One source ClinicalTrials.gov |
| UNII (FDA) | 2XOI31YC4N | PRETOMANID | Confirmed FDA, Wikidata |
| RxNorm | 2198359 | — | One source FDA |
| Wikidata | Q7118312 | pretomanid | Confirmed FDA, Wikidata |
| NCI Thesaurus | C166606 | Pretomanid | One source FDA |
| DrugBank | DB05154 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.