Phosphodiesterase Inhibitors: all 583 studies that test it

Page 1 of 6. Open to participants first (87), then studies with results posted, then the rest; newest registration first within each.

• DDI Study of ECC0509 With Metformin, Midazolam, and CaffeineNot yet recruitingNCT07873229Phase 1
• Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear CellsNot yet recruitingNCT07873047Not applicable
• Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill RunRecruitingNCT07854223Not applicable
• Intravenous Papaverine for Term Prelabor Rupture of MembranesRecruitingNCT07826533Not applicable
• Predicting Response and Exposure Changes in Cirrhosis for EffectivenessNot yet recruitingNCT07750587Not applicable
• Placebo Effect on Cycling Performance: Laboratory Crossover StudyNot yet recruitingNCT07748429Not applicable
• The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.Not yet recruitingNCT07748416Not applicable
• Placebo Effect in Field-Based Physical PerformanceNot yet recruitingNCT07742150Not applicable
• Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological EffectsNot yet recruitingNCT07738562Phase 1/2
• TCP-600 Supplementation and Performance Response in Professional Football PlayersRecruitingNCT07710547Not applicable
• Papaverine and Sublingual Microcirculation in Septic ShockNot yet recruitingNCT07657741Not applicable
• Caffeine and Prophylactic Noradrenaline Requirement During Cesarean DeliveryNot yet recruitingNCT07655245Not applicable
• Papaverine for Prevention of Perineal TraumaNot yet recruitingNCT07641543Not applicable
• Pentoxifylline Add-On Therapy for Mild-to-Moderate Plaque PsoriasisNot yet recruitingNCT07626788Not applicable
• Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.RecruitingNCT07617896Phase 2
• A Single-Arm, Prospective Study of Papaverine for the Treatment of Refractory Peripheral Neuropathy Induced by Taxane-Based ChemotherapyNot yet recruitingNCT07572461Not applicable
• Pharmacokinetics and Placental Transfer of CaffeineRecruitingNCT07570121Phase 1
• Effects of L-Tyrosine and Caffeine on Performance in Elite BoxersNot yet recruitingNCT07530185Not applicable
• I.V Papavrine for Labor Induction in Term PROMRecruitingNCT07517796Phase 4
• Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture HeadacheRecruitingNCT07515456Not applicable
• Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer OutcomesRecruitingNCT07499817Phase 3
• Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in MalesEnrolling by invitationNCT07466732Early Phase 1
• Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory SupportNot yet recruitingNCT07456670Phase 2
• Caffeine Strategies and Fat OxidationEnrolling by invitationNCT07402902Not applicable
• Pentoxifylline in Patients With Ulcerative ColitisRecruitingNCT07349472Phase 2
• Improving Preterm Kidney Outcomes With CaffeineRecruitingNCT07262060Phase 2
• Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With AsthenozoospermiaRecruitingNCT07252518Not applicable
• Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon CatheterRecruitingNCT07237880Not applicable
• Vinpocetine in Patients With Parkinsonian DiseaseRecruitingNCT07229664Phase 2/3
• Caffeine Optimization for Oxygen Saturation Index in ELBW InfantsRecruitingNCT07216365Phase 2
• The Effect of Short-term Supplementation of OliPhenolia® on Fat OxidationRecruitingNCT07210099Not applicable
• A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With DipyridamoleRecruitingNCT07199504Phase 2/3
• Nephroprotection Following Perinatal Asphyxia: Randomized Controlled TrialNot yet recruitingNCT07088328Not applicable
• Cocaine and Pentoxifylline (BED IN 47)RecruitingNCT07086794Early Phase 1
• To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver SurgeryRecruitingNCT07085806Not applicable
• Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University HospitalsRecruitingNCT07022496Phase 4
• Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid ArthritisRecruitingNCT06998628Phase 2
• Caffeine Citrate to Improve Neonatal Outcomes.Not yet recruitingNCT06972849Not applicable
• CAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO)Not yet recruitingNCT06972108Phase 2
• The Repeatability of the Effect of Caffeine Supplementation on Submaximal Physiological Responses and Cycling Time Trial PerformanceNot yet recruitingNCT06935214Not applicable
• Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)RecruitingNCT06912763Phase 2
• Pentoxifylline for Vascular Calcification in Kidney DiseaseNot yet recruitingNCT06903689Phase 1/2
• Caffeine for Hypoxic Ischemic EncephalopathyRecruitingNCT06855108Phase 3
• Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE TrialRecruitingNCT06834126Phase 1
• Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant RecipientsRecruitingNCT06824454Phase 2
• Bioequivalence Study of Pentoxifylline 400 Mg in Healthy Subjects Under Fasting and Fed ConditionsNot yet recruitingNCT06823362Phase 4
• Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase LevelsNot yet recruitingNCT06704711Not applicable
• Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail ApproachRecruitingNCT06693960Early Phase 1
• Dose Escalation Study of Vinpocetine in Healthy VolunteersNot yet recruitingNCT06635746Phase 1
• Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing ChemoradiationRecruitingNCT06634056Phase 2
• Papaverine and Oxytocin vs Oxytocin Alone in Labor InductionNot yet recruitingNCT06547437Not applicable
• CYP1A2 and ADORA2A Genotypes and Endurance Performance.RecruitingNCT06547307Not applicable
• Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric PopulationRecruitingNCT06538584Phase 1/2
• Caffeine Citrate in Preterm Infants at Risk of Apnea in ZambiaRecruitingNCT06518603Phase 4
• Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)RecruitingNCT06494111Phase 2
• PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]Not yet recruitingNCT06461429Not applicable
• Clinical Outcome of Vinpocetine in Diabetic NephropathyRecruitingNCT06441591Phase 2/3
• Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease PatientsRecruitingNCT06421870Phase 3
• The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrateRecruitingNCT06401083Phase 4
• Effect of Pentoxifylline on Cognitive Impairment After Ischemic StrokeRecruitingNCT06344390Phase 1/2
• Motivational, Affective and Performance Effects of Caffeine SupplementationRecruitingNCT06321861Not applicable
• Efficacy of Intralesional Injection of Pentoxifylline, Platelet-Rich Plasma, and Combined Pentoxifylline With Platelet-Rich Plasma in Patients With Atrophic Acne ScarsRecruitingNCT06319768Not applicable
• Prevention of Cisplatin-induced NephrotoxicityNot yet recruitingNCT06196853Phase 2/3
• Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata.Not yet recruitingNCT06087796Phase 1
• Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior DecompensationNot yet recruitingNCT06041932Not applicable
• Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the ElderlyRecruitingNCT06040489Phase 2/3
• Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory DistressRecruitingNCT06026163Phase 2/3
• Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer OutcomesNot yet recruitingNCT05971667Phase 2/3
• Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill AdultsRecruitingNCT05933642Phase 2/3
• Caffeine in the Second Stage of Labor in Low-risk Nulliparous Mothers at TermNot yet recruitingNCT05906303Phase 1
• Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active MenNot yet recruitingNCT05897034Phase 2/3
• The PENTO Protocol in Medication-related Osteonecrosis of the JawRecruitingNCT05795647Phase 2
• Consequences of Caffeine Intake in Sleep Restricted TeenagersRecruitingNCT05790161Not applicable
• Oxygen Toxicity: Mechanisms in HumansRecruitingNCT05761756Not applicable
• The Effect of IV PAPAVERINE 80 mg Prior to Catheter Balloon Insertion on Bishop Score and PainRecruitingNCT05759364Not applicable
• Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary DysplasiaRecruitingNCT05682807Phase 3
• Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger SyndromeRecruitingNCT05611268Not applicable
• Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung CancerRecruitingNCT05136846Phase 1
• Reverse Triple Negative Immune Resistant Breast CancerRecruitingNCT05076682Phase 2
• BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome.RecruitingNCT04666454Phase 4
• Regeneration in Cervical Degenerative MyelopathyRecruitingNCT04631471Phase 3
• Effect of CAFfeine on Cognition in Alzheimer's DiseaseRecruitingNCT04570085Phase 3
• Theophylline for Treatment of PseudohypoparathyroidismEnrolling by invitationNCT04240821Phase 2
• Effect of add-on Doxofylline on Lung Function in Stable COPDNot yet recruitingNCT04238221Phase 4
• Topical Pentoxifylline Gel on Behcet's Disease Genital UlcersNot yet recruitingNCT04186559Phase 2
• Effect of Theophylline in PseudohypoparathyroidismRecruitingNCT03718403Phase 4
• Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung CancersRecruitingNCT01871454Phase 2
• Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)CompletedNCT05947643Phase 2Results posted
• Awake Caudal Catheter vs General AnesthesiaCompletedNCT05919732Phase 4Results posted
• A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver CirrhosisCompletedNCT05741385Not applicableResults posted
• A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to PlaceboCompletedNCT05485805Phase 3Results posted
• Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney DiseaseActive, not recruitingNCT05284656Phase 3Results posted
• Brequinar Combined With Dipyridamole in Patients With Mild to Moderate COVID-19TerminatedNCT05166876Phase 2Results posted
• Oral Caffeine Use for Pain Management in AIS Patients After Spinal FusionCompletedNCT04950660Phase 4Results posted
• Smell in Covid-19 and Efficacy of Nasal TheophyllineCompletedNCT04789499Phase 2Results posted
• A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the BloodCompletedNCT04679948Phase 1Results posted
• A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by KetamineCompletedNCT04602221Phase 1Results posted
• Efficacy, Safety, Tolerability, and Biomarkers of Ibudilast (MN-166) in Patients Hospitalized With COVID-19 at Risk for ARDSCompletedNCT04429555Phase 2Results posted
• Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy AdultsCompletedNCT04425902Phase 1Results posted
• Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19TerminatedNCT04424901Phase 2Results posted

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