Drug

Metformin clinical trials

Also written Glucophage, Glumetza and BR3006C.

Includes 12 studies of Extended Release Metformin Hydrochloride.

studies test it: 1,290
open now: 160
in phase 3: 237
first study started: 1996

Related medicines add 8 studies

Counted the way a researcher would: Metformin with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.

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How each study uses Metformin is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

Get an email when these change. Save the Metformin studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

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Approvals

The first approval found in each region, with its record

United States: 3 Mar 1995 · GLUCOPHAGE · NDA 020357 (FDA, Drugs@FDA)
European Union: 20 Oct 2003 · Avandamet · EMEA/H/C/000522 (EMA; in a combination; now expired)

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Metformin: 835
Metformin Hydrochloride: 86
Metformin HCl: 19
Metformin XR: 19
Cidophage: 17

Brand

Glucophage: 223
Glumetza: 35
Fortamet: 33
Riomet: 30
Glucophage XR: 23
Diabex: 7
Glucophage 1000mg: 1
Glucophage 500mg: 1

Development codes

BR3006C: 2
EFB0027: 1

In one entry with another drug

Given together, or one or the other

Pioglitazone and Metformin: 7
Sitagliptin/Metformin FDC: 5
Sitagliptin/metformin: 5
Sitagliptin + Metformin: 4
empagliflozin/metformin: 4
Xigduo: 3
Empagliflozin and Metformin: 3
rosiglitazone/metformin: 3

Studies by the year they started

1,272 studies that test it; most in 2014 (80); 4 more planned to start later

Studies that test Metformin, by start year
Year	Studies
1996	2
1997	1
1999	1
2000	5
2001	11
2002	16
2003	28
2004	24
2005	29
2006	29
2007	21
2008	42
2009	39
2010	44
2011	68
2012	75
2013	73
2014	80
2015	68
2016	77
2017	57
2018	61
2019	63
2020	42
2021	47
2022	62
2023	51
2024	46
2025	65
2026	45

By phase

A phase 1/2 study counts in both.

Early Phase 1: 43
Phase 1: 261
Phase 2: 359
Phase 3: 237
Phase 4: 293
No phase: 180

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Diabetes Mellitus, Type 2: 251
Polycystic Ovary Syndrome: 105
Obesity: 35
Diabetes, Gestational: 29
Breast Neoplasms: 29
Prostatic Neoplasms: 28
Prediabetic State: 23
Diabetes Mellitus: 23
Diabetes Mellitus, Type 1: 18
Insulin Resistance: 16
Non-alcoholic Fatty Liver Disease: 15
Metabolic Syndrome: 14

Who runs them

Industry 289 · Other 1,001

AstraZeneca (26) · Boehringer Ingelheim (24) · Novo Nordisk A/S (19) · Merck Sharp & Dohme LLC (19) · Sanofi (16) · University of California, San Francisco (13) · Assiut University (13) · GlaxoSmithKline (13)

Often tested with

Tested in the same studies.

Sitagliptin (49) · Pioglitazone (43) · Empagliflozin (31) · Dapagliflozin (27) · Liraglutide (23) · Linagliptin (23) · Glimepiride (22) · Insulin Glargine (21)

Related medicines

As reviewed, each with the page that says it.

One of Hypoglycemic Agents source
One of Biguanides source

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Tested against it · 10 phase 3 studies under way

Metformin is the comparator. A study of two new drugs counts under both.

2Semaglutide · University of Hull, University of Colorado, Denver · next primary completion Oct 2029
1Dorzagliatin · University of Alabama at Birmingham
1Fezolinetant · University of Colorado, Denver · next primary completion Oct 2029
1Dapagliflozin · The George Institute

Reaching primary completion within a year · 56, 9 in phase 3

Studies that test Metformin, phase 3 first.

Nov 2026Metformin Safety and Efficacy in Osteoarthritis.Phase 3 · Mostafa Bahaa
Nov 2026Metformin in Parkinson DiseasePhase 2/3 · Tanta University
Feb 2027MetfOrmin BenefIts Lower Extremities With Intermittent ClaudicationPhase 3 · VA Office of Research and Development
Mar 2027Efficacy of Vildagliptin Versus Metformin in Patients With Polycystic Ovary SyndromePhase 2/3 · Tanta University
Mar 2027Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)Phase 3 · University Of Nigeria Teaching Hospital
Apr 2027Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary SyndromePhase 2/3 · Tanta University
Aug 2027Metformin Treatment for Children With Obesity-associated AsthmaPhase 3 · Prof Ibrahim Janahi
Sep 2027Impact of Metformin on Peripheral Arterial Calcification in Type 1 DiabetesPhase 3 · Assistance Publique - Hôpitaux de Paris
Nov 2027Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain TumourPhase 3 · Donald Mabbott
Nov 2026Role of Metformin on Muscle Health of Older AdultsEarly Phase 1 · University of Utah

Studies

Open first, then newest update. How each study uses Metformin is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 1,290

See all 1,290 studies that test Metformin →

Given beside what is tested · 439 — Metformin is usual care or a partner of the new treatment

Showing 20 of 439.

As the comparator · 170 — what is tested is compared with Metformin

Showing 20 of 170.

What changed recently

From the registry's own updates since Oct 15, 2026.

Codes

What other systems call Metformin · ClinicalTrials.gg INT007796

MeSH (NLM) D008687MetforminConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) 9100L32L2NMETFORMINConfirmed FDA, NLM, Wikidata
RxNorm 6809Confirmed FDA, Wikidata
Wikidata Q19484metforminConfirmed FDA, NLM, Wikidata
NCI Thesaurus C61612MetforminOne source FDA
DrugBank DB00331One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	D008687	Metformin	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	9100L32L2N	METFORMIN	Confirmed FDA, NLM, Wikidata
RxNorm	6809	—	Confirmed FDA, Wikidata
Wikidata	Q19484	metformin	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C61612	Metformin	One source FDA
DrugBank	DB00331	—	One source Wikidata

Also registered as metformin hydrochloride (UNII 786Z46389E · RxNorm 235743).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.